Onatril

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  • Contains / Salt: Clonazepam (0.5 mg)
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Onatril Information

Onatril, a prescription drug, is manufactured in various forms such as Tablet. Primarily, it is used for the treatment of Malaria.

Medical history of the patient along with age and gender determines the dosage of Onatril. Dosage also depends on the route of administration and your chief complaint for which the drug is prescribed. This information has been provided in detail in the dosage section.

While these are the most often observed Onatril side effects, there are can be others also. These have been listed below. Normally, these side effects of Onatril are not long lasting and go away when the treatment is finished. However, if these continue for a longer time, consult your doctor right away.

Furthermore, you should know that effect of Onatril is Severe for pregnant women and Severe for women who are breastfeeding. Further, the section on Onatril related warnings talks about Onatril's effects on the liver, heart and kidney.

Onatril is contraindicated in people with pre-existing medical conditions like Porphyria as it can result in adverse effects. Some other conditions that can be affected by Onatril are listed in the contraindications section below.

Drug reaction of Onatril with other medicines has been reported. See below for a complete list.

In addition to these precautions, you may also note that Onatril is not safe while driving, and is is not addictive in nature.



Onatril Benefits & Uses

Onatril is used to treat the following -

Main Benefits

Onatril Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Malaria
  • Before or After Meal: After Meal
  • Single Maximum Dose: 300 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 3 days
  • Special Instructions: Initial dose should be given 600 mg as a base, after 6 hours 300 mg base and for next 2 days 300 mg base OD
Geriatric
  • Disease: Malaria
  • Before or After Meal: After Meal
  • Single Maximum Dose: 300 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 3 days
  • Special Instructions: Initial dose should be given 600 mg as a base, after 6 hours 300 mg base and for next 2 days 300 mg base OD
13 - 18 years (Adolescent)
  • Disease: Malaria
  • Before or After Meal: After Meal
  • Single Maximum Dose: 5 mg/kg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 3 days
  • Special Instructions: Initial dose should be given 10 mg/kg as a base, after 6 hours 5 mg/kg base and for next 2 days 5 mg/kg base OD
2 - 12 years (Child)
  • Disease: Malaria
  • Before or After Meal: After Meal
  • Single Maximum Dose: 5 mg/kg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 3 days
  • Special Instructions: Initial dose should be given 10 mg/kg as a base, after 6 hours 5 mg/kg base and for next 2 days 5 mg/kg base OD
Infant (1 month to 2 years)
  • Disease: Malaria
  • Before or After Meal: After Meal
  • Single Maximum Dose: 5 mg/kg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 3 days
  • Special Instructions: Initial dose should be given 10 mg/kg as a base, after 6 hours 5 mg/kg base and for next 2 days 5 mg/kg base OD


Onatril Side Effects

Based on research, the following side effects have been observed when Onatril is used -

Onatril Related Warnings

  • Is the use of Onatril safe for pregnant women?


    Onatril shows severe side effect on pregnant women. For this reason, pregnant women should only take it after taking medical advice.

    Severe
  • Is the use of Onatril safe during breastfeeding?


    Onatril may cause serious side effects in breastfeeding women, so do not take this drug without doctor's advice.

    Severe
  • What is the effect of Onatril on the Kidneys?


    Onatril can have moderate side effects on the kidney. If you notice any harmful effects, stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate
  • What is the effect of Onatril on the Liver?


    There may be an adverse effect on the liver after taking Onatril. If you observe any side effects on your body then stop taking this drug. Take this medicine again only if your doctor advises you to do so.

    Moderate
  • What is the effect of Onatril on the Heart?


    There may be an adverse effect on the heart after taking Onatril. If you observe any side effects on your body then stop taking this drug. Restart this medicine only if your doctor advises you to do so.

    Moderate


Severe Interaction of Onatril with Other Drugs

Onatril should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate



Onatril Contraindications

If you are suffering from any of the following diseases, you should not take Onatril unless your doctor advises you to do so -



Frequently asked Questions about Onatril

  • Is this Onatril habit forming or addictive?


    Onatril does not cause addiction.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    After taking Onatril you may feel sleepy. So it is not advised to perform these activities.

    Dangerous
  • Is it safe?


    Onatril should be used only after doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    Onatril is unable to treat or cure mental disorders.

    No

Onatril Interactions with Food and Alcohol

  • Interaction between Food and Onatril


    There is no information on the effects of taking Onatril with food, because this topic has not been scientifically researched yet.

    Unknown
  • Interaction between Alcohol and Onatril


    Due to lack of research, nothing can be said about side effects of consuming alcohol while taking Onatril.

    Unknown


Frequently asked Questions about Onatril

Question over 4 years ago

Does Onatril cause tinnitus?

Dr. Saurabh Dhamdhere MBBS , Orthopedics

Yes, Onatril has been reported to cause tinnitus (ringing in the ears) and also hearing loss which is reversible and goes away after discontinuation of this drug. It is a known side effect of this drug. If you experience ringing in the ears after taking this medicine, then inform your doctor about without any further delay.

Question about 5 years ago

Can I take Onatril without consulting a doctor?

Dr. Gaurav MBBS , General Physician

No, Onatril is a prescription drug so do not take it without consulting a doctor. It can cause unpleasant side effects if taken without a doctor's recommendation. Hence, the patient should seek doctors advice before taking this medication by himself or herself.

Question almost 5 years ago

Can Onatril cause fatigue?

Dr. Kuldeep Meena MBBS, MD , Cardiology, Neurology, Pediatrics, Dermatology, Pulmonology, Nephrology, General Physician, Other, Infectious Disease, Emergency Medicine, Allergy and Immunology, Internal Medicine, Multispeciality

Yes, Onatril can cause fatigue, this occurs in a few cases only. It is a rare side effect of this drug. However, the exact cause of fatigue is unknown. If you experience tiredness after taking this drug, then try to take some rest even after that if you feel excessive tiredness then do discuss with your doctor.

Question about 5 years ago

How does Onatril work?

Dr. Abhijit MBBS , General Physician

Onatril contains chloroquine. It has antimalarial, amebicidal, and immunosuppressant activity. It is presumed that Onatril works by increasing pH in the acid vesicles of parasite which interferes in the parasite's ability to break down and digest hemoglobin. Malarial parasites need hemoglobin for growth and survival. This results in starvation and death of parasites. Onatril works in rheumatoid arthritis and systemic lupus erythematosus (SLE) by suppressing the immune system which provides relief to the patient from pain and inflammation. However, the exact mechanism how it works in these autoimmune diseases is still unknown.

Question about 4 years ago

Is Onatril helpful in lupus?

Dr Anjum Mujawar MBBS, MBBS , Emergency Medicine

Yes, Onatril is helpful in lupus or systemic lupus erythematosus (SLE). It is used in the treatment of systemic lupus erythematosus (SLE) as well as rheumatoid arthritis. Onatril works in rheumatoid arthritis and systemic lupus erythematosus (SLE) by suppressing the immune system which provides relief to the patient from pain and inflammation. However, the exact mechanism how Onatril works in these autoimmune diseases is still unknown.



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This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

KD Tripathi. Package leaflet information for the user; Aralen® Chloroquine phosphate. Eighth Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2019

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 211



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