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What is Heart Transplantation?

Heart failure (HF) affects millions of individuals worldwide. Heart transplantation is a surgical technique, popularized by Dr. Norman Shumway. It successfully remains the best option for patients with heart diseases and is an end-stage treatment where conservative management cannot help. The aim of a successful surgery is to reduce donor-recipient time, post-operative complications and maintain the overall success that heart transplantation has achieved over the years.

Indications for heart transplantation differ between institutions. Recipient is the person needing the new heart. Most of these candidates have long-term heart failure for a number of years, but few individuals with recent heart failure may be offered transplantation as the only option to prolong survival. The donor is the person donating the heart.

Who needs it?

In general, patients with advanced HF should be considered for heart transplantation if optimal medical therapy fails. It is also considered when cardiac revival therapy has failed to improve symptoms or halt the improvement of this disease. Furthermore, any reversible or surgically correctable cardiac conditions should be addressed before transplantation is considered. The latter is important to guarantee the candidacy for a heart transplant and reserve organs for the more needed patients. Patients, who are in their advanced stage, need evaluation by advanced HF teams for optimal management of multi-organ failure. Patients with severe HF have a 1 to 2-year mortality rate approaching 50% despite advanced medical treatment. The primary indications for heart transplantation for adult patients have been non-ischemic cardiomyopathy (53%) and ischemic cardiomyopathy (38%). Other indications include valvular heart disease (3%), re-transplantation (3%) and others (<1%).

How is it performed?

Heart transplantation requires an incision through the sternum or the breastbone, and the use of a cardiopulmonary bypass machine (heart-lung machine) that functions as the patient’s heart and lungs during the operation. The donor’s heart is removed or ‘retrieved’ by the surgical team after a complete assessment to ensure its adequate function. Meanwhile, the recipient has his/her heart removed and the surgeon connects the donor heart onto the recipient’s major vessels. Once the connections are restored and the heart is functioning properly, the patient is hooked off the heart-lung machine and the transplanted heart takes over the functioning entirely. 

  1. Medicines for Heart Transplant

Medicines for Heart Transplant

Medicines listed below are available for Heart Transplant. Please note that you should not take any medicines without doctor consultation. Taking any medicine without doctor's consultation can cause serious problems.

Medicine NamePack SizePrice (Rs.)
TacrografTACROGRAF 5MG CAPSULE 10S0
EczridEczrid 0.3% Ointment168
ImografImograf 0.03% W/W Ointment136
KivitroKivitro 0.03 Mg Ointment102
OlixOlix 0.1% Ointment216
OlmisOlmis 0.03% W/W Ointment96
TacosealTacoseal 0.1%W/W Ointment81
TacrodermTacroderm 0.03% Ointment77
TacrojonTacrojon 0.1% Ointment260
TacrokidTacrokid 0.03% Ointment88
TacromTacrom 0.03% Ointment75
TacromentTacroment 0.03% Ointment96
TacropexTacropex 1 Mg Ointment239
TacrotopicTacrotopic 0.03% Ointment96
TacrotorTacrotor 0.03% Ointment135
TacrovateTacrovate 0.03% Ointment74
TacroveraTacrovera 0.03% Ointment86
TacrozTacroz Forte Ointment 10gm399
TacvidoTacvido 0.03% Ointment140
TakfaTakfa 0.03% Ointment96
TalimusTalimus 0.03% Ointment76
TbisTbis 0.1% Ointment 10gm338
TecumTecum 0.03% Ointment96
TopgrafTopgraf 0.03% Ointment114
AcroliAcroli 3% Ointment87

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References

  1. Allen Cheng et al. Heart transplantation. J Thorac Dis. 2014 Aug; 6(8): 1105–1109. PMID: 25132977
  2. N. de Jonge et al. Guidelines for heart transplantation. Neth Heart J. 2008 Mar; 16(3): 79–87. PMID: 18345330
  3. M. Chadi Alraies et al. Adult heart transplant: indications and outcomes. J Thorac Dis. 2014 Aug; 6(8): 1120–1128. PMID: 25132979
  4. Christopher Harris et al. Heart transplantation. Ann Cardiothorac Surg. 2018 Jan; 7(1): 172. PMID: 29492396
  5. MedlinePlus Medical Encyclopedia: US National Library of Medicine; Heart Transplantation

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