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Psoriasis is an autoimmune disorder and a chronic disorder in which the skin becomes red and scaly. Though this skin inflammation is the most visible sign of psoriasis, the disease can also lead to inflammation in the internal organs and joints.

Psoriatic arthritis is a kind of inflammation (swelling) of the joints that develops in people with psoriasis; the affected joints become swollen and are often quite painful. Typically, people with psoriatic arthritis have psoriasis for a few years before developing symptoms of arthritis.

As this is a kind of arthritis, the signs and symptoms may include:

  • Swollen or stiff joints.
  • Pain in the muscles
  • Scaly patches on the skin
  • Involvement of small joints, such as those of the fingers, toes, wrists, ankles and elbows

Eye problems, too, start to occur in certain cases, the most common being conjunctivitis and uveitis.

Psoriatic arthritis, like psoriasis, is thought to occur when the immune system attacks healthy tissues. It is not clear what triggers these attacks, but a combination of genetic factors and environmental factors, such as stress, a viral infection or an injury, are thought to play a role.

Based on the symptoms of joint problems or stiffness, the physician may suggest tests and refer the individual to a rheumatologist for further assessment. Common tests carried out to determine the type of arthritis are X-rays and blood tests to look for raised levels of erythrocyte sedimentation rate and C-reactive protein test.

There's no single medication that would work on every case of arthritis, so a number of medications may have to be tried before a suitable and effective medication is found. Anti-inflammatory and anti-rheumatic drugs may be prescribed along with physical therapy to help with movements and joint issues. Medications, such as corticosteroids, biologics (biotech drugs) or immunosuppressants may also be prescribed.

Psoriatic arthritis tends to be persistent—it is difficult to be rid of it completely. However, with the right medications and therapy, one can avoid a relapse. On World Psoriasis Day, marked each year on 29 October to raise awareness, we bring to you information about a condition that affects anywhere from 7% to 26% of psoriasis patients: psoriatic arthritis.

  1. Types of psoriatic arthritis
  2. Psoriatic arthritis symptoms
  3. Psoriatic arthritis causes
  4. Psoriatic arthritis diagnosis
  5. Psoriatic arthritis treatment
  6. Medicines for Psoriatic arthritis
  7. Doctors for Psoriatic arthritis

Types of psoriatic arthritis

There are at least five types of psoriatic arthritis, depending on which joints are affected by it and the severity of the disease:

  • Symmetric psoriatic arthritis affects multiple joints on both sides of the body. For example, the elbows and knees of both the right and left arm.
  • Asymmetric psoriatic arthritis affects the joints on one side of the body. It can affect one joint (asymmetric monoarthritis) or multiple joints on either side of the body (asymmetric oligoarthritis).
  • Distal interphalangeal psoriatic arthritis affects the fingers and the toes—the joints nearest to the nails.
    • Psoriatic onycho-pachydermo-periostitis is a variation of psoriatic arthritis which also affects the nails (psoriatic nails) and fingers/toes. Other signs of this condition include thickening of connective tissue above the distal phalanx (tips of fingers and toes) and erosion of the bones of the distal phalanges (last sections or tips of fingers and toes).
  • Spondylitis psoriatic arthritis affects the spine, though it can also affect the hands, arms, feet, legs and hips. This form of psoriatic arthritis can be painful, and it can make even movements hurt.
  • Psoriatic arthritis mutilans is a rare but severe condition that affects the hands and feet though it can also cause neck pain and back pain. This types of arthritis can affect the small bones and deform/shorten the fingers and toes. In fact, some of the better-known manifestations of psoriatic arthritis—like pencil-in-cup deformity (the tip of a bone in the finger becomes like the pointy end of a pencil) and telescoping fingers (when the soft tissues can't support the fingers properly and they look pulled in)—occur in this condition.

Psoriatic arthritis symptoms

Some patients may have mild symptoms while others may have more severe disease. The symptoms can also vary in the same individual: they may feel okay on some days but poorly when the symptoms return.

The symptoms and which parts of the body they affect can vary depending on the type of psoriatic arthritis. Having said that, the following are some of the general symptoms of psoriatic arthritis:

  • Swelling and pain in the joints
  • Joint stiffness, especially in the mornings
  • Muscle pain and pain in the tendons (the connective tissue that connects muscle to bones)
  • Scaly, red patches on the skin worsen when the joint pain and swelling is worse
  • Inflammation of the conjunctiva (tissue on the inner side of the eyelid and over the whites of the eye) or uvea (the layer just below the whites of the eye)
  • Nail pitting, or the formation of pits (dents) in the nails where they have lost cells. In case of nail psoriasis, the nails may become discoloured, detached from the nail bed (onycholysis), thicker (onychomycosis), or they may crumble and/or develop lines (Beau's lines) all over.
  • Inflammation in the sacroiliac joint where the spine and pelvis connect (sacroiliitis)
  • People with psoriatic arthritis could also face issues with cardiac rhythm and inflammation in other parts of the body such as:
  • Depending on the type of psoriatic arthritis, patients may also experience foot pain, especially heel pain and pain in the soles of their feet, or back pain
  • Psoriatic arthritis often affects the hands and feet. In these cases, the symptoms could include:
    • Inflammation in the area where the tendons and ligaments join the bone (enthesitis) and marginal bone erosions
    • Bone proliferation in some areas
    • Joint subluxation or partial dislocation of a joint which may resolve on its own
    • A fusion of bones in the fingers or toes (interphalangeal ankylosis) which makes it harder to move them
    • Dactylitis or swelling in the soft tissue of the entire digit (finger or toe); also known as sausage fingers or sausage toes
    • Periostitis or inflammation in a layer of connective tissue surrounding the bones
    • Ivory phalanx: A rare but important symptom of psoriatic arthritis, marked by increased density of the bone that is observable in scans

Psoriatic arthritis causes

Psoriasis and psoriatic arthritis are autoimmune conditions, meaning they are caused when the body's immune system makes a mistake and starts attacking healthy cells. Doctors don't yet know why this happens, but they suspect that genetics may have something to do with it. Additionally, in people who are genetically prone to this disease, environmental factors such as a viral or bacterial infection could trigger psoriatic arthritis.

Some of the risk factors of psoriatic arthritis are:

  • Psoriasis: Psoriasis typically begins as a skin condition, but it can also cause inflammation inside the body too. When this inflammation affects the bones and connective tissues, it can result in psoriatic arthritis.
  • Family history: Having a family history of psoriasis or psoriatic arthritis can make one more prone to the condition.
  • Age: Psoriatic arthritis can occur at any age but it is frequently seen in people aged 30-50.

Psoriatic arthritis diagnosis

A skin specialist is usually the first to catch the signs of psoriatic arthritis in patients who have psoriasis. This is because psoriasis typically presents as overproduction of skin cells which appear scaly and red and shed very fast.

Based on the symptoms described by the patient and a physical examination of the joint that may be painful or swollen, the doctor may recommend a few tests to confirm their suspicions:

  • An X-ray can help see whether the joint is inflamed
  • An MRI or magnetic resonance imaging test can do the same but at a much higher resolution
  • CT scan to study the bone erosion and bone proliferation associated with psoriatic arthritis

The doctor may also order a few tests to rule out other conditions, such as:

Psoriatic arthritis treatment

Though it isn't entirely possible to prevent psoriatic arthritis, it is possible to slow it down and manage its symptoms by maintaining a healthy weight and managing your psoriasis with medicines.

If you have psoriasis, regular checkups are also important to diagnose any complications of psoriasis—including psoriatic arthritis—early on and start management.

Psoriatic arthritis and its symptoms can be managed with a combination of drugs and therapies including:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen for pain relief and to reduce inflammation
  • Disease-modifying antirheumatic drugs (DMARDs) like methotrexate to slow down disease progression and damage to the joints
  • Immunosuppressants like azathioprine and cyclosporine to stop the immune system from attacking healthy cells in an autoimmune condition (read more: Cyclosporine test)
  • Biologics or biologic response modifiers such as abatacept, adalimumab, infliximab and tofacitinib to target specific parts of the immune system for reducing inflammation and slowing down disease progression
  • Steroid injections may be given to reduce inflammation quickly
  • Joint replacement surgery may be recommended to patients if the joints are severely damaged
  • In their day-to-day life, patients should include exercises for psoriatic arthritis and heat-and-cold therapy to improve mobility and reduce inflammation
Dr. Urmish Donga

Dr. Urmish Donga

Orthopedics
3 Years of Experience

Dr. Sridhar Reddy

Dr. Sridhar Reddy

Orthopedics
4 Years of Experience

Dr. Sunil Kumar Yadav

Dr. Sunil Kumar Yadav

Orthopedics
3 Years of Experience

Dr. Deep Chakraborty

Dr. Deep Chakraborty

Orthopedics
10 Years of Experience

Medicines for Psoriatic arthritis

Medicines listed below are available for Psoriatic arthritis. Please note that you should not take any medicines without doctor consultation. Taking any medicine without doctor's consultation can cause serious problems.

Medicine Name
Enbrel खरीदें
Etacept खरीदें
Intacept खरीदें
Orencia खरीदें
Exemptia खरीदें
Acton Prolongatum खरीदें
Acton खरीदें
Pdlast खरीदें
Aprezo Tablet खरीदें
Aplex खरीदें
Apxenta खरीदें
Plamumab खरीदें
Remicade खरीदें
Infimab खरीदें
Aplex Kit खरीदें

References

  1. National Health Service [Internet]. UK; Psoriatic arthritis.
  2. Artur Jacek Sankowski et al. Psoriatic arthritis. Pol J Radiol. 2013 Jan-Mar; 78(1): 7–17. PMID: 23493653
  3. National Psoriasis Foundation [Internet] reviewed on 10/23/18; Psoriatic Arthritis.
  4. MedlinePlus Medical Encyclopedia: US National Library of Medicine; Psoriatic Arthritis
  5. National Institute of Arthritis and Musculoskeletal and Skin Diseases [Internet]. National Institute of Health; Psoriatic Arthritis.
  6. Jung-Tai Liu et al. Psoriatic arthritis: Epidemiology, diagnosis, and treatment . World J Orthop. 2014 Sep 18; 5(4): 537–543. PMID: 25232529
  7. Dafna D. Gladmana et al. Recent advances in understanding and managing psoriatic arthritis . Version 1. F1000Res. 2016; 5: 2670. PMID: 27928500
  8. Radiopedia [Internet]. Psoriatic arthritis.
  9. Busse K., Liao W. Which psoriasis patients develop psoriatic arthritis? Psoriasis Forum, Winter 2010; 16(4): 17-25. PMID: 25346592.
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