What is an Anti-Neutrophil Cytoplasmic Antibody (ANCA) profile test?
ANCAs are autoantibodies produced against certain proteins present in neutrophils, a type of white blood cell. An ANCA test is used to detect the presence of these autoantibodies in your blood.
The two most common types of neutrophil proteins that are targetted by these autoantibodies are myeloperoxidase (MPO) and proteinase 3 (PR3). So, to identify the specific type of ANCA, MPO and PR3 tests are suggested in case ANCA test results come out to be positive. All three tests are performed together in some cases.
The test can be of two types:
- Direct immunofluorescence microscopy
- Immunoassay method