Doran O

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Doran O Information

Doran O is a prescription medicine that is available as a Injection, Tablet. Nausea and Vomiting are some of its major therapeutic uses.

The correct dosage of Doran O depends on the patient's age, gender, and medical history. Individual symptoms and route of administration also determines the right dosage. For detailed information on this, read through the dosage section.

Besides the aforementioned side effects, there are other adverse effects of Doran O as well, which are listed below. Such side effects of Doran O normally do not last long and go away once the treatment is completed. However, if these continue for a longer time, consult your doctor right away.

It is also important to note that Doran O has a Safe effect for pregnant women and Mild effect on lactating mothers. It is important to know if Doran O has any effect on the kidney, liver and heart. Information on such adverse effects, if any, has been given in the Doran O related warnings section.

Doran O is not recommended if you suffer from certain medical conditions as it can have adverse effects. Heart Disease, Calcium Deficiency, Potassium Deficiency are examples of such conditions. Other conditions have been mentioned below in the Doran O contraindications section.

Drug interactions for Doran O have been reported in the medical literature. See below for a complete list.

You should also be aware that Doran O is not safe while driving, and is not addiction.



Doran O Benefits & Uses

Doran O is used to treat the following -

Doran O Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Nausea and Vomiting
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 0.15 mg/kg
  • Dosage Route: Parenteral
  • Frequency: once only
  • Course Duration: As directed by the doctor
  • Special Instructions: Given 30 minutes prior to the initiation of emetogenic chemotherapy.
Geriatric
  • Disease: Nausea and Vomiting
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 0.15 mg/kg
  • Dosage Route: Parenteral
  • Frequency: once only
  • Course Duration: As directed by the doctor
  • Special Instructions: Given 30 minutes prior to the initiation of emetogenic chemotherapy.
13 - 18 years (Adolescent)
  • Disease: Nausea and Vomiting
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 0.15 mg/kg
  • Dosage Route: Parenteral
  • Frequency: once only
  • Course Duration: As directed by the doctor
  • Special Instructions: Given 30 minutes prior to the initiation of emetogenic chemotherapy.
2 - 12 years (Child)
  • Disease: Nausea and Vomiting
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 0.15 mg/kg
  • Dosage Route: Parenteral
  • Frequency: once only
  • Course Duration: As directed by the doctor
  • Special Instructions: Given 30 minutes prior to the initiation of emetogenic chemotherapy.
Infant (1 month to 2 years)
  • Disease: Nausea and Vomiting
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 0.15 mg/kg
  • Dosage Route: Parenteral
  • Frequency: once only
  • Course Duration: As directed by the doctor
  • Special Instructions: Given 30 minutes prior to the initiation of emetogenic chemotherapy. Given dose older then 6 month

Doran O Related Warnings

  • Is the use of Doran O safe for pregnant women?


    Doran O is safe to take during pregnancy.

    Safe
  • Is the use of Doran O safe during breastfeeding?


    Doran O has been seen to have minimal side effects on breastfeeding women.

    Mild
  • What is the effect of Doran O on the Kidneys?


    There are no side effects of Doran O on the kidneys.

    Safe
  • What is the effect of Doran O on the Liver?


    Doran O can have moderate side effects on the liver. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate
  • What is the effect of Doran O on the Heart?


    You may experience side effects on your heart after taking Doran O. If this happens, then discontinue its use. Consult your medical practitioner, and do as he/she suggests.

    Moderate


Severe Interaction of Doran O with Other Drugs

Doran O should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate



Doran O Contraindications

If you are suffering from any of the following diseases, you should not take Doran O unless your doctor advises you to do so -



Frequently asked Questions about Doran O

  • Is this Doran O habit forming or addictive?


    Doran O does not cause addiction.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should not drive or operate heavy machinery after taking Doran O as you may feel sleepy.

    Dangerous
  • Is it safe?


    Doran O is safe but it is important to consult a doctor before taking it.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, the use of Doran O in mental disorders is not effective.

    No

Doran O Interactions with Food and Alcohol

  • Interaction between Food and Doran O


    You can take Doran O with food.

    Safe
  • Interaction between Alcohol and Doran O


    Taking alcohol with Doran O can be dangerous.

    Severe


Frequently asked Questions about Doran O

Question about 5 years ago

How to take Doran O?

Dr. Saurabh Shakya MBBS , General Physician

Doran O is available in form of tablet, syrup, and injection. It should be taken as per your doctor's instructions. Ideally, Doran O has to be taken with food to avoid stomach upset. The initial dose is usually taken half an hour before chemotherapy, 1 to 2 hours before radiation therapy and 1 hour before a surgery. Additional doses can be suggested by the doctor as per the individual requirements.

Question about 5 years ago

How does Doran O work?

Dr. Uday Nath Sahoo MBBS , Internal Medicine

Doran O belongs to a class of compounds known as 5 -HT3 receptor antagonists. It blocks the action of serotonin completely at the 5-HT3 receptor sites present in our brain (vomiting centre) which provides relief to the patient from nausea and vomiting.

Question almost 5 years ago

Can Doran O be taken with tramadol?

Dr. Braj Bhushan Ojha BAMS , Gastroenterology, Dermatology, Psychiatry, Ayurveda, Sexology, Diabetology

No, Doran O should not be ideally taken with tramadol as the action of both the drugs decreases upon concomitant use. Tramadol is an opioid medication used to treat mild to moderate pain. Take it only when a doctor has prescribed it. ​

Question about 5 years ago

Can Doran O be taken for motion sickness?

Dr. Ajay Kumar MBBS, MD , General Physician

No, Doran O is not found to be effective against motion sickness. It prevents vomiting due to chemotherapeutic drugs and radiation. Motion sickness is the disturbance of the inner ear caused by a lot of motion. It can be prevented by not taking too much food or too many drinks or alcohol just before the travel. One should also avoid food with very strong odours. One should avoid reading while traveling. One should also sit in the direction of the travel. One should sit in the front. Open a vent of fresh air and try to be relaxed while traveling. 

Question about 5 years ago

Is Doran O safe for children?

Dr. R.K Singh MBBS , Diabetology

Yes, Doran O is safe to be used in children from 6 months to 12 years of age. Apart from preventing nausea and vomiting related to chemotherapy and radiation, Doran O can be used in this population group for managing acute gastritis. Acute gastritis presents itself as a self-limited infection with vomiting leading to dehydration and electrolyte imbalances. Always check with a child specialist and do not administer this drug yourself.



See all substitutes for Doran O


This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 947-948

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 668

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Zofran (ondansetron hydrochloride)

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Zofran® (ondansetron hydrochloride)



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