Neotrexate

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Neotrexate Information

Neotrexate is a commercial drug that is prescribed in the form of Tablet, Injection. Non-Hodgkin Lymphoma, Lymphoma are some of its major therapeutic uses. Other than this, Neotrexate has some other therapeutic uses, which have been discussed ahead.

The correct dosage of Neotrexate depends on the patient's age, gender, and medical history. The condition it has been prescribed for, and the route of administration also determine the right dosage. For detailed information on this, read through the dosage section.

Neotrexate also has some side effects, the most common being Abdominal Pain. Some other side effects of Neotrexate have been listed ahead. These side effects of Neotrexate are usually temporary and subside with the completion of treatment. Please speak with your doctor if these side effects worsen or persist for a longer duration.

Furthermore, you should know that effect of Neotrexate is Severe for pregnant women and Severe for women who are breastfeeding. Further, the section on Neotrexate related warnings talks about Neotrexate's effects on the liver, heart and kidney.

Neotrexate is contraindicated in people with pre-existing medical conditions like Infections, Liver Disease, Anemia as it can result in adverse effects. The section on Neotrexate contraindications lists all such conditions.

Additionally, Neotrexate may also adversely react with other medicines. Refer to the list below for further details.

You should also be aware that Neotrexate is safe while driving, and is addiction.



Neotrexate Benefits & Uses

Neotrexate is used to treat the following -

Other Benefits

Neotrexate Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: B-Cell Acute Lymphoblastic Leukemia
  • Before or After Meal: Either
  • Single Maximum Dose: 5 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: B-Cell Acute Lymphoblastic Leukemia
  • Before or After Meal: Either
  • Single Maximum Dose: 5 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor

Neotrexate Related Warnings

  • Is the use of Neotrexate safe for pregnant women?


    Neotrexate can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.

    Severe
  • Is the use of Neotrexate safe during breastfeeding?


    Women who are breastfeeding, may experience serious side effects after taking Neotrexate. So it is adviced to consult the doctor before using it.

    Severe
  • What is the effect of Neotrexate on the Kidneys?


    Kidney can be affected by Neotrexate. If you experience any unwanted effects of this drug, stop taking it. You should take it again only after medical advice.

    Moderate
  • What is the effect of Neotrexate on the Liver?


    The liver can be affected by Neotrexate. If you experience any unwanted effects of this drug, stop taking it and consult your doctor. You should restart Neotrexate only after medical advice.

    Moderate
  • What is the effect of Neotrexate on the Heart?


    Neotrexate may have mild side effects on the heart. Most people will never see any effect on the heart.

    Mild


Severe Interaction of Neotrexate with Other Drugs

Neotrexate should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate



Neotrexate Contraindications

If you are suffering from any of the following diseases, you should not take Neotrexate unless your doctor advises you to do so -



Frequently asked Questions about Neotrexate

  • Is this Neotrexate habit forming or addictive?


    No, you will not get addicted to Neotrexate.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    Neotrexate does not cause dizziness or sleep, so you can drive a vehicle or operate machinery also.

    Safe
  • Is it safe?


    Yes, but take Neotrexate only as per medical advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Neotrexate cannot treat any kind of mental disorder.

    No

Neotrexate Interactions with Food and Alcohol

  • Interaction between Food and Neotrexate


    Due to the absence of research, it is difficult to say how Neotrexate and food will interact.

    Unknown
  • Interaction between Alcohol and Neotrexate


    Taking [medicine] and alcohol at the same time may lead to mild side effects. Contact your doctor right away if you observe any side effects.

    Mild


Frequently asked Questions about Neotrexate

Question over 5 years ago

What is Neotrexate?

Dr. R.K Singh MBBS , Diabetology

Neotrexate is a brand name of methotrexate and it comes in the form of tablet and injection. It is a chemotherapy drug that belongs to the class of drug known as antimetabolites and it also has immunosuppressant properties. It is a prescription drug which is used for the treatment of various types of cancers such as breast cancer, bone cancer, head, and neck cancer. It is also used in the treatment of autoimmune and inflammatory diseases such as psoriasis, rheumatoid arthritis, and Crohn's disease.

Question over 4 years ago

Does Neotrexate cause cancer?

Dr. Uday Nath Sahoo MBBS , Internal Medicine

Neotrexate contains methotrexate (a chemotherapy) which is used in the treatment of various types of cancers. Nonetheless, it has been associated with an increased risk for melanoma, non-Hodgkin's lymphoma, and lung cancer.

Question about 5 years ago

Is Neotrexate safe to use?

Dr. , General Physician

Yes, Neotrexate is safe to use, if taken in prescribed amount and duration as advised by the doctor. However, certain side effects have been associated with this drug such as gingivitis (inflammation of gum), mouth ulcers, and diarrhoea. If you experience above-mentioned side effects after taking this medicine then inform your doctor and follow his/her instructions.

Question over 4 years ago

Does Neotrexate raise blood sugar?

Dr. Abhijit MBBS , General Physician

No, Neotrexate does not raise blood sugar levels (hyperglycemia). It has not been reported by the patients who are taking it. However, if you are experiencing increased thirst, trouble concentrating, and frequent urination which are symptoms of increased blood sugar levels (hyperglycemia) then do discuss with your doctor.

Question about 5 years ago

How to take Neotrexate?

Dr. Kuldeep Meena MBBS, MD , Cardiology, Neurology, Pediatrics, Dermatology, Pulmonology, Nephrology, General Physician, Other, Infectious Disease, Emergency Medicine, Allergy and Immunology, Internal Medicine, Multispeciality

The dosage of this drug may vary depending on the diagnosis and the patient's medical condition. Take Neotrexate as advised by your doctor. Ideally, oral Neotrexate has to be taken empty stomach because the presence of food might affect the absorption of this drug from the stomach. Precautions must be taken in patients with bone marrow depression, and improper liver or kidney function.



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This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Methotrexate

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 862-863

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 832-834

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