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Letrozole is a prescription medicine. Primarily, it is used for the treatment of Breast Cancer.
The right dosage of Letrozole depends on the age, gender, and medical history of the patient. Individual symptoms and route of administration also determines the right dosage. Refer to the dosage section for a detailed discussion.
The side effects typically associated with Letrozole include Hot Flashes, Musculoskeletal Pain (Bone, Muscle or Joint). While these are the most often observed Letrozole side effects, there are can be others also. These have been listed below. Normally, these side effects of Letrozole are not long lasting and go away when the treatment is finished. Please speak with your doctor if these side effects worsen or persist for a longer duration.
It is also important to note that Letrozole has a Severe effect for pregnant women and Severe effect on lactating mothers. It is important to know if Letrozole has any effect on the kidney, liver and heart. Information on such adverse effects, if any, has been given in the Letrozole related warnings section.
Individuals suffering from medical conditions like Liver Disease must refrain from the use of Letrozole since this can cause severe adverse effects. The section on Letrozole contraindications lists all such conditions.
Besides this, Letrozole may also have severe interaction with some medicines. See below for a complete list.
You should also be aware that Letrozole is not safe while driving, and is not addiction.
Letrozole is used to treat the following -
Other Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
Age Group | Dosage |
Adult(Female) |
|
Geriatric |
|
Based on research, the following side effects have been observed when Letrozole is used -
Severe
Mild
Common
Is the use of Letrozole safe for pregnant women?
Letrozole has many dangerous side effects in pregnant women. If you are pregnant, do not consume Letrozole without medical advice.
Is the use of Letrozole safe during breastfeeding?
Letrozole should not be taken without taking your doctor's advice, as it may have severe side effects on breastfeeding women.
What is the effect of Letrozole on the Kidneys?
Letrozole has very mild side effects on the kidneys.
What is the effect of Letrozole on the Liver?
Letrozole can have moderate side effects on the liver. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.
What is the effect of Letrozole on the Heart?
There may be an adverse effect on the heart after taking Letrozole. If you observe any side effects on your body then stop taking this drug. Restart this medicine only if your doctor advises you to do so.
Letrozole should not be taken with following medicines due to severe side effects it may cause to patients -
Severe
Moderate
If you are suffering from any of the following diseases, you should not take Letrozole unless your doctor advises you to do so -
Is this Letrozole habit forming or addictive?
Letrozole is not addictive in nature.
Is it safe to drive or operate heavy machinery when consuming?
No, you should do not do anything that requires concentration and attention as the Letrozole can make you feel drowsy.
Is it safe?
Letrozole is safe but it is important to consult a doctor before taking it.
Is it able to treat mental disorders?
No, Letrozole is not used to treat mental disorders.
Interaction between Food and Letrozole
There isn't any research available on the side effects of taking Letrozole with food.
Interaction between Alcohol and Letrozole
Due to lack of research, nothing can be said about side effects of consuming alcohol while taking Letrozole.
No, Letrozole is a prescription drug so do not take it without consulting a doctor. It can be harmful to the patient to take this medicine without a doctor's recommendation because it can cause unpleasant side effects. Hence, the patient should seek doctors advice before taking this medication by himself or herself.
Yes, Letrozole might be used in the treatment of endometriosis along with other drugs but generally, it is not preferred as the first-line drug of choice for endometriosis.
Rarely, Letrozole causes weight fluctuation (weight gain or weight loss). However, the exact cause behind weight fluctuation is unknown but it is presumed that this occurs due to fluctuation in hormone levels in the body caused by this drug. If you experience any unusual sudden weight gain or loss after taking this drug, then consult it with your doctor without further delay.
Take Letrozole once daily or as advised by your doctor. It has been taken with or without food because the presence of food does not affect the absorption of this drug from the stomach. Precautions must be taken in patients with osteoporosis, fracture, and improper liver function.
Yes, Letrozole and metformin can be taken together because no harmful drug interaction has been reported between them. Hence, it is safe to take Letrozole along with metformin.
This medicine data has been created by -
B.Pharma, Pharmacy
5 Years of Experience
References
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 758
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 314-315
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Femara (letrozole)