Clozap

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Clozap Information

Clozap is a prescription medicine that is available as a Tablet. It is typically used for the treatment of Schizophrenia. The alternative uses of Clozap have also been explained below.

The optimal dosage of Clozap is largely dependent on the individual's body weight, medical history, gender and age. Individual symptoms and route of administration also determines the right dosage. This information has been provided in detail in the dosage section.

The side effects typically associated with Clozap include Blurred vision. Some other side effects of Clozap have been listed ahead. Such side effects of Clozap normally do not last long and go away once the treatment is completed. If, however, they worsen or do not go away, please speak with your physician.

Furthermore, you should know that effect of Clozap is Mild for pregnant women and Severe for women who are breastfeeding. In addition, Clozap's effects on the liver, heart and kidney are discussed below in the Clozap related warnings section.

Clozap is not recommended if you suffer from certain medical conditions as it can have adverse effects. Tardive Dyskinesia, Depression, Parkinson's Disease are examples of such conditions. Other conditions have been mentioned below in the Clozap contraindications section.

Besides this, Clozap may also have severe interaction with some medicines. See below for a complete list.

You should also be aware that Clozap is not safe while driving, and is not addiction.



Clozap Benefits & Uses

Clozap is used to treat the following -

Main Benefits

Other Benefits

Clozap Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Schizophrenia
  • Before or After Meal: After Meal
  • Single Maximum Dose: 12.5 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: gradually increase 25 - 50 mg/day over a period of 2 week up to target dose of 300 - 450 mg/day
Geriatric
  • Disease: Schizophrenia
  • Before or After Meal: After Meal
  • Single Maximum Dose: 12.5 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: gradually increase 25 - 50 mg/day over a period of 2 week up to target dose of 300 - 450 mg/day

Clozap Related Warnings

  • Is the use of Clozap safe for pregnant women?


    Clozap has little to no side effects in pregnant women.

    Mild
  • Is the use of Clozap safe during breastfeeding?


    Clozap may cause serious side effects in breastfeeding women, so do not take this drug without doctor's advice.

    Severe
  • What is the effect of Clozap on the Kidneys?


    Clozap may have mild side effects on the kidneys.

    Mild
  • What is the effect of Clozap on the Liver?


    Clozap has very mild side effects on the liver.

    Mild
  • What is the effect of Clozap on the Heart?


    Clozap can have moderate side effects on the heart. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate


Severe Interaction of Clozap with Other Drugs

Clozap should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate

AcarboseChlorpheniramine,Dextromethorphan,Paracetamol,Phenylephrine
    Paracetamol,Tramadol


      Clozap Contraindications

      If you are suffering from any of the following diseases, you should not take Clozap unless your doctor advises you to do so -



      Frequently asked Questions about Clozap

      • Is this Clozap habit forming or addictive?


        Forming a habit of Clozap has not been reported.

        No
      • Is it safe to drive or operate heavy machinery when consuming?


        No, you should do not do anything that requires concentration and attention as the Clozap can make you feel drowsy.

        Dangerous
      • Is it safe?


        Clozap should be used only after doctor's advice.

        Safe, but take only on Doctor's advise
      • Is it able to treat mental disorders?


        Clozap has been seen to have positive effect on patients with mental disorders.

        Yes

      Clozap Interactions with Food and Alcohol

      • Interaction between Food and Clozap


        When consumed with certain foods, Clozap may take longer to have an effect. Contact your doctor about this.

        Mild
      • Interaction between Alcohol and Clozap


        Consuming Clozap with alcohol can have many serious effects on your body.

        Severe


      See all substitutes for Clozap


      This medicine data has been created by -

      Vikas Chauhan

      B.Pharma, Pharmacy
      5 Years of Experience


      References

      US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Clozaril® (clozapine)

      KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 175,471

      April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 56-58

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