Defibrotide Benefits & Uses

Defibrotide is used to treat the following -

Main Benefits

Liver Disease

Defibrotide Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group	Dosage
Adult	Disease: Liver Disease Before or After Meal: As advised by a physician Single Maximum Dose: 6.25 mg/kg Dosage Route: Parenteral Frequency: 6 hourly Course Duration: 2 months Special Instructions: used in hepatic veno-occlusive disease, given as every 6 hours constant 2-hour infusion
Geriatric	Disease: Liver Disease Before or After Meal: As advised by a physician Single Maximum Dose: 6.25 mg/kg Dosage Route: Parenteral Frequency: 6 hourly Course Duration: 2 months Special Instructions: used in hepatic veno-occlusive disease, given as every 6 hours constant 2-hour infusion
13 - 18 years (Adolescent)	Disease: Liver Disease Before or After Meal: As advised by a physician Single Maximum Dose: 6.25 mg/kg Dosage Route: Parenteral Frequency: 6 hourly Course Duration: 2 months Special Instructions: used in hepatic veno-occlusive disease, given as every 6 hours constant 2-hour infusion
2 - 12 years (Child)	Disease: Liver Disease Before or After Meal: As advised by a physician Single Maximum Dose: 6.25 mg/kg Dosage Route: Parenteral Frequency: 6 hourly Course Duration: 2 months Special Instructions: used in hepatic veno-occlusive disease, given as every 6 hours constant 2-hour infusion
Infant (1 month to 2 years)	Disease: Liver Disease Before or After Meal: As advised by a physician Single Maximum Dose: 6.25 mg/kg Dosage Route: Parenteral Frequency: 6 hourly Course Duration: 2 months Special Instructions: used in hepatic veno-occlusive disease, given as every 6 hours constant 2-hour infusion

Defibrotide Side Effects

Based on research, the following side effects have been observed when Defibrotide is used -

Severe

Angioedema
Infection
Hyperuricemia

Mild

Nausea or vomiting
Diarrhoea
Rash
Urticaria

Defibrotide Related Warnings

Is the use of Defibrotide safe for pregnant women?

The effects of Defibrotide on pregnant women are unknown since no research has been done to ascertain it yet.

Unknown
Is the use of Defibrotide safe during breastfeeding?

No research work has been carried out till date on effect of Defibrotide on breastfeeding women. So it is not known whether taking Defibrotide will cause side effects or not.

Unknown
What is the effect of Defibrotide on the Kidneys?

Defibrotide is not harmful for kidneys.

Safe
What is the effect of Defibrotide on the Liver?

Defibrotide is completely safe for the liver.

Safe
What is the effect of Defibrotide on the Heart?

Defibrotide is not harmful for the heart.

Safe

Severe Interaction of Defibrotide with Other Drugs

Defibrotide should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Abciximab

Aspirin(ASA),Paracetamol,Caffeine

Alteplase

Anistreplase

Anistreplase Injection

Apixaban

Aspirin(ASA)

Argatroban

Argatroban Injection

Defibrotide Contraindications

If you are suffering from any of the following diseases, you should not take Defibrotide unless your doctor advises you to do so -

Bleeding

Frequently asked Questions about Defibrotide

Is this Defibrotide habit forming or addictive?

No, you will not get addicted to Defibrotide.

No
Is it safe to drive or operate heavy machinery when consuming?

No, you should not drive or operate heavy machinery after taking Defibrotide as you may feel sleepy.

Dangerous
Is it safe?

Yes, Defibrotide is safe but you must consult your doctor before taking it.

Safe, but take only on Doctor's advise
Is it able to treat mental disorders?

There is no benefit of taking Defibrotide for mental disorders.

No

Defibrotide Interactions with Food and Alcohol

Interaction between Food and Defibrotide

There isn't any research available on the side effects of taking Defibrotide with food.

Unknown
Interaction between Alcohol and Defibrotide

No research has been done on this till date. Therefore, it is not known what the effect of taking Defibrotide with alcohol will be.

Unknown