Metformin + Pioglitazone

Yes, Metformin + Pioglitazone can be taken with the statin. There is no serious or harmful interaction have been observed between them. Some studies say that it's possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.

Lactic acidosis associated with Metformin + Pioglitazone treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Metformin + Pioglitazone induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Yes, you can take Metformin + Pioglitazone with gliclazide, no harmful interactions have been reported between them. However, it is not necessary that no interaction can happen between these two. But before taking such kind of combination you must consult your doctor.

No, you should not take alcohol with Metformin + Pioglitazone, because it can cause serious side effects which includes hypoglycemia (low blood sugar). The risk of hypoglycemia is higher when you're drinking and taking Metformin + Pioglitazone than if you're just taking Metformin + Pioglitazone. Some of the signs of hypoglycemia include dizziness, confusion, and drowsiness.

Metformin + Pioglitazone is not a known cause of alopecia (hair loss). However, the conditions treated by Metformin + Pioglitazone type 2 diabetes and PCOS, often list hair loss as a possible symptom.