Xifapill

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Xifapill Information

Xifapill, a prescription drug, is manufactured in various forms such as Tablet. Hepatic Encephalopathy are some of its major therapeutic uses. Xifapill also has some secondary and off-label uses. These are listed below.

The correct dosage of Xifapill depends on the patient's age, gender, and medical history. The condition it has been prescribed for, and the route of administration also determine the right dosage. Refer to the dosage section for a detailed discussion.

The side effects typically associated with Xifapill include Flatulence, Bloating or fullness, Constipation. Apart from the aforementioned side effects, Xifapill can also lead to other problems, which have been listed below. Such side effects of Xifapill normally do not last long and go away once the treatment is completed. However, if these continue for a longer time, consult your doctor right away.

It is also important to note that Xifapill has a Severe effect for pregnant women and Severe effect on lactating mothers. Further, the section on Xifapill related warnings talks about Xifapill's effects on the liver, heart and kidney.

Other conditions have been mentioned below in the Xifapill contraindications section.

Drug interactions for Xifapill have been reported in the medical literature. A complete list of these interactions is given below.

You should also be aware that Xifapill is safe while driving, and is addiction.



Xifapill Benefits & Uses

Xifapill is used to treat the following -

Main Benefits

Other Benefits

Xifapill Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Traveler's Diarrhea
  • Before or After Meal: Either
  • Single Maximum Dose: 200 g
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 3 daily
  • Course Duration: 3 days
  • Special Instructions: As prescribed by the doctor
13 - 18 years (Adolescent)
  • Disease: Traveler's Diarrhea
  • Before or After Meal: Either
  • Single Maximum Dose: 200 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: 3 days
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Traveler's Diarrhea
  • Before or After Meal: Either
  • Single Maximum Dose: 200 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 3 daily
  • Course Duration: 3 days
  • Special Instructions: As prescribed by the doctor

Xifapill Related Warnings

  • Is the use of Xifapill safe for pregnant women?


    Xifapill can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.

    Severe
  • Is the use of Xifapill safe during breastfeeding?


    Xifapill may cause serious side effects in breastfeeding women, so do not take this drug without doctor's advice.

    Severe
  • What is the effect of Xifapill on the Kidneys?


    Using Xifapill does not have any harmful effects on kidneys.

    Safe
  • What is the effect of Xifapill on the Liver?


    Xifapill has very mild side effects on the liver.

    Mild
  • What is the effect of Xifapill on the Heart?


    Xifapill is completely safe for the heart.

    Safe


Severe Interaction of Xifapill with Other Drugs

Xifapill should not be taken with following medicines due to severe side effects it may cause to patients -

Moderate



Xifapill Contraindications

If you are suffering from any of the following diseases, you should not take Xifapill unless your doctor advises you to do so -



Frequently asked Questions about Xifapill

  • Is this Xifapill habit forming or addictive?


    No, there is no any evidence that Xifapill is addictive.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    Xifapill does not cause dizziness or sleep, so you can drive a vehicle or operate machinery also.

    Safe
  • Is it safe?


    Xifapill should be used only after doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    Xifapill is unable to treat or cure mental disorders.

    No

Xifapill Interactions with Food and Alcohol

  • Interaction between Food and Xifapill


    You can take Xifapill with food.

    Safe
  • Interaction between Alcohol and Xifapill


    It is difficult to say anything about the effect of Xifapill and alcohol. No research has been done on this yet.

    Unknown


Frequently asked Questions about Xifapill

Question almost 5 years ago

Can Xifapill cause headache?

Dr. Uday Nath Sahoo MBBS , Internal Medicine

Yes, Xifapill might cause a headache. It is a rare side effect of this drug. However, the exact cause of a headache is still unknown. If you experience a severe headache after taking this drug, take a mild painkiller, apply balm and take rest even after this if the pain does not subside then discuss with your doctor without any further delay.

Question about 5 years ago

Can I take Xifapill without consulting a doctor?

Dr. Roshni Poonja MBBS , General Physician, Internal Medicine

No, Xifapill is a prescription drug and an antibiotic, hence do not take this drug without consulting doctor to avoid bacterial resistance and unpleasant side effects. It can be harmful for patients to take this medicine without the doctor's advice.

Question over 4 years ago

Does Xifapill work for SIBO (Small Intestinal Bacterial Overgrowth)?

Dr. Roshni Poonja MBBS , General Physician, Internal Medicine

The use of Xifapill for the treatment of small intestinal bacterial overgrowth (SIBO) is not approved and scientific evidence supporting its use for SIBO is not sufficient.

Question almost 5 years ago

Does Xifapill cause weight gain?

Dr. Haleema Yezdani MBBS , General Physician

No, Xifapill does not cause weight gain. It has not been reported by the patients who are taking this drug but Xifapill has been reported to cause weight loss in a few patients with travelers’ diarrhea. If you notice any unusual rapid weight changes after taking this drug then discuss with it your doctor and follow his/her instructions.

Question over 5 years ago

How does Xifapill work?

Dr. Anand Singh MBBS , General Physician

Xifapill works by inhibiting the bacterial protein synthesis which is essential for bacterial growth. The absence of these proteins results in stunned bacterial growth due to which bacteria is not able to survive. For hepatic encephalopathy Xifapill works by inhibiting the growth of enteric ammonia-producing bacteria which are present in our gut, this results in the indirect reduction of serum ammonia level. In irritable bowel syndrome with diarrhea, how Xifapill works are still unknown but it is presumed that it works by changing the bacterial flora in small intestine and reduction in gas.



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This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Xifaxan® (rifaximin)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 681-683

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1096-1097

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