Sodium Valproate

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  • Contains / Salt: Sodium Valproate
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Sodium Valproate Information

Sodium Valproate is a prescription medicine. Epilepsy are some of its major therapeutic uses. The alternative uses of Sodium Valproate have also been explained below.

The right dosage of Sodium Valproate depends on the age, gender, and medical history of the patient. Besides the medical condition it is advised for, the route of administration also plays an important role in determining the correct drug dosage. Detailed information has been provided in the dosage section.

The most common side effects of Sodium Valproate are Loss of appetite. Besides the aforementioned side effects, there are other adverse effects of Sodium Valproate as well, which are listed below. Normally, these side effects of Sodium Valproate are not long lasting and go away when the treatment is finished. However, if these continue for a longer time, consult your doctor right away.

It is also important to note that Sodium Valproate has a Severe effect for pregnant women and Mild effect on lactating mothers. In addition, Sodium Valproate's effects on the liver, heart and kidney are discussed below in the Sodium Valproate related warnings section.

Sodium Valproate can cause adverse effects in certain medical conditions. It is strongly recommended to avoid Sodium Valproate in conditions like Depression, Liver Disease. Some other conditions that can be affected by Sodium Valproate are listed in the contraindications section below.

Drug reaction of Sodium Valproate with other medicines has been reported. See below for a complete list.

In addition to these precautions, you may also note that Sodium Valproate is not safe while driving, and is is not addictive in nature.



Sodium Valproate Benefits & Uses

Sodium Valproate is used to treat the following -

Main Benefits

Other Benefits

Sodium Valproate Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Epilepsy
  • Before or After Meal: After Meal
  • Single Maximum Dose: 15 mg/kg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: dose may increase 5 to 10 mg/kg per week if necessary
Geriatric
  • Disease: Epilepsy
  • Before or After Meal: After Meal
  • Single Maximum Dose: 15 mg/kg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: dose may increase 5 to 10 mg/kg per week if necessary


Sodium Valproate Side Effects

Based on research, the following side effects have been observed when Sodium Valproate is used -

Severe

  • Nausea or vomiting
  • Drowsiness
  • Weight gain
  • Dizziness
  • Blurred vision

Moderate

Mild

Common

  • Loss of appetite

Sodium Valproate Related Warnings

  • Is the use of Sodium Valproate safe for pregnant women?


    Sodium Valproate should not be taken during pregnancy, or should only be taken on the advice of a doctor as it may have severe side effects.

    Severe
  • Is the use of Sodium Valproate safe during breastfeeding?


    Sodium Valproate may have very limited harmful effects for breastfeeding women.

    Mild
  • What is the effect of Sodium Valproate on the Kidneys?


    Sodium Valproate rarely affects the kidneys.

    Mild
  • What is the effect of Sodium Valproate on the Liver?


    Sodium Valproate may have mild side effects on the liver. Most people will never see any effect on the liver.

    Mild
  • What is the effect of Sodium Valproate on the Heart?


    There are no any side effects of Sodium Valproate for the heart.

    Safe


Severe Interaction of Sodium Valproate with Other Drugs

Sodium Valproate should not be taken with following medicines due to severe side effects it may cause to patients -

Moderate



Sodium Valproate Contraindications

If you are suffering from any of the following diseases, you should not take Sodium Valproate unless your doctor advises you to do so -



Frequently asked Questions about Sodium Valproate

  • Is this Sodium Valproate habit forming or addictive?


    Sodium Valproate is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should not drive or operate heavy machinery after taking Sodium Valproate as you may feel sleepy.

    Dangerous
  • Is it safe?


    Yes, but take Sodium Valproate only as per medical advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    Sodium Valproate has been seen to have positive effect on patients with mental disorders.

    Yes

Sodium Valproate Interactions with Food and Alcohol

  • Interaction between Food and Sodium Valproate


    It is safe to take Sodium Valproate with food.

    Safe
  • Interaction between Alcohol and Sodium Valproate


    Consuming Sodium Valproate with alcohol can have many serious effects on your body.

    Severe


Frequently asked Questions about Sodium Valproate

Question about 5 years ago

Does Sodium Valproate affects birth control?

Dr. Prakash kumar MBBS , General Physician

Yes, Sodium Valproate can affect birth control, because it decreases the effect of the oral contraceptive pill which can alter the contraceptive effects. Talk to your doctor before taking these two medications together because you need extra protection to control birth. 

Question over 5 years ago

How does Sodium Valproate work?

Dr. OP Kholwad MBBS , General Physician

Sodium Valproate works by relaxing the muscles of the body and suppressing abnormal activity of nerve cells in the brain through an increase in activity of a chemical messenger known as GABA (gamma-aminobutyric acid) by inhibiting the enzymes which are responsible for the catabolism of GABA. It also exerts effect altering the sodium channel in the brain. It also works by stabilizing the potassium channel and cause a direct membrane-stabilizing effect. Thus, providing relief from the seizure and mania associated with bipolar disorder.

Question almost 5 years ago

Can Sodium Valproate cause memory loss?

Dr. Sangita Shah MBBS , General Physician

Yes, Sodium Valproate can cause memory loss. All drugs that depress signaling in the CNS can cause memory loss. If you experience memory loss after taking medicine, please consult your doctor immediately and follow his/her instructions.

Question almost 5 years ago

Can I take Sodium Valproate with Paracetamol?

Dr. Manju Shekhawat MBBS , General Physician

Avoid taking Sodium Valproate with paracetamol it may reduce the bioavailability of paracetamol by increasing the metabolism of paracetamol. Increasing the concentration of paracetamol in the blood which may cause liver damage. Please consult your doctor before taking these two medicines at the same time.

Question over 5 years ago

What is Sodium Valproate?

Dr. K. M. Bhatt MBBS, PG Dip , Cardiology, Pediatrics, General Surgery, General Physician, Emergency Medicine, Physical Medicine

Sodium Valproate is a brand name for sodium valproate. It is a prescription drug that belongs to the class of medicine called anti-epileptic drug, also known as an anticonvulsant and anti-seizure medication. It is used in the treatment of epilepsy (seizure). It is also used to treat mania associated bipolar disorder and prevent the episodes of a migraine headache. The injectable form of this drug is used to treat complex partial seizures, simple and complex absence seizures.



See all substitutes for Sodium Valproate


This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Depakene (valproic acid)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 417-418



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