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Melieva contains Melphalan, a chemotherapy medication belonging to the class of alkylating agents. It is primarily used to treat multiple myeloma and ovarian cancer. Melphalan interferes with the DNA replication of cancer cells, inhibiting their growth and spread.
Treatment of multiple myeloma
Treatment of ovarian cancer
Treatment of certain cases of breast cancer and neuroblastoma (off-label)
Melphalan cross-links DNA strands, leading to impaired DNA replication and cell death. This action affects rapidly dividing cancer cells more than normal cells.
Multiple myeloma: Typically, 0.15 mg/kg orally daily for 4 to 7 days in intermittent cycles.
Ovarian cancer: Usually 0.2 mg/kg orally daily for 5 days, repeated every 4 to 5 weeks.
Onset of Action: Several days to weeks after starting treatment.
Duration of Action: Dependent on the dose and type of cancer treated; effects are prolonged due to its impact on DNA.
Nausea and vomiting
Hair loss (alopecia)
Bone marrow suppression
Fatigue
Diarrhea
Mouth sores
Increased risk of infection
Regular blood tests are required to monitor blood cell counts.
Avoid live vaccines during treatment.
Use effective contraception to prevent pregnancy during treatment.
Inform the doctor of any history of liver, kidney, or heart problems.
Store tablets in a cool, dry place away from direct sunlight.
Melieva is used to treat the following -
Main Benefits
Other Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
| Age Group | Dosage |
| Adult |
|
| Adult(Female) |
|
| Geriatric |
|
Based on research, the following side effects have been observed when Melieva is used -
Moderate
Mild
Unknown
Is the use of Melieva safe for pregnant women?
Melieva has many dangerous side effects in pregnant women. If you are pregnant, do not consume Melieva without medical advice.
Is the use of Melieva safe during breastfeeding?
Melieva should not be taken without taking your doctor's advice, as it may have severe side effects on breastfeeding women.
What is the effect of Melieva on the Kidneys?
Melieva has very mild side effects on the kidneys.
What is the effect of Melieva on the Liver?
Melieva may have mild side effects on the liver. Most people will never see any effect on the liver.
What is the effect of Melieva on the Heart?
Melieva has very mild side effects on the heart.
Melieva should not be taken with following medicines due to severe side effects it may cause to patients -
Severe
Moderate
If you are suffering from any of the following diseases, you should not take Melieva unless your doctor advises you to do so -
Is this Melieva habit forming or addictive?
Melieva does not cause addiction.
Is it safe to drive or operate heavy machinery when consuming?
No, you should do not do anything that requires concentration and attention as the Melieva can make you feel drowsy.
Is it safe?
Melieva should be used only after doctor's advice.
Is it able to treat mental disorders?
No, the use of Melieva in mental disorders is not effective.
Interaction between Food and Melieva
It is safe to take Melieva with food.
Interaction between Alcohol and Melieva
Due to lack of research, nothing can be said about side effects of consuming alcohol while taking Melieva.
This medicine data has been created by -
References
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Evomela (melphalan)
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 861
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 810-812
