Metformin

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Metformin Information

Metformin is a prescription medicine. Diabetes are some of its major therapeutic uses.

Medical history of the patient along with age and gender determines the dosage of Metformin. Dosage also depends on the route of administration and your chief complaint for which the drug is prescribed. This information has been provided in detail in the dosage section.

The most common side effects of Metformin are Stomach Upset, Difficulty urinating. Some other side effects of Metformin have been listed ahead. Normally, these side effects of Metformin are not long lasting and go away when the treatment is finished. Consult your doctor if these side effects become worse or stay for a longer duration.

Metformin's effect during pregnancy is Mild and Moderate while nursing. It is important to know if Metformin has any effect on the kidney, liver and heart. Information on such adverse effects, if any, has been given in the Metformin related warnings section.

Individuals suffering from medical conditions like Congestive Heart Failure (CHF), Anemia, Shock must refrain from the use of Metformin since this can cause severe adverse effects. Some other conditions that can be affected by Metformin are listed in the contraindications section below.

Drug interactions for Metformin have been reported in the medical literature. See below for a complete list.

Along with the above-mentioned precautions, remember that taking Metformin is considered safe while driving, and is addictive.



Metformin Benefits & Uses

Metformin is used to treat the following -

Main Benefits

Metformin Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Diabetes Type 2
  • Before or After Meal: With meal
  • Single Maximum Dose: 500 mg
  • Dosage Form: Tablet (Immediate Release)
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Diabetes Type 2
  • Before or After Meal: With meal
  • Single Maximum Dose: 500 mg
  • Dosage Form: Tablet (Immediate Release)
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
13 - 18 years (Adolescent)
  • Disease: Diabetes Type 2
  • Before or After Meal: With meal
  • Single Maximum Dose: 500 mg
  • Dosage Form: Tablet (Immediate Release)
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
2 - 12 years (Child)
  • Disease: Diabetes Type 2
  • Before or After Meal: With meal
  • Single Maximum Dose: 500 mg
  • Dosage Form: Tablet (Immediate Release)
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor

Metformin Related Warnings

  • Is the use of Metformin safe for pregnant women?


    Pregnant women may get mild side effects from Metformin.

    Mild
  • Is the use of Metformin safe during breastfeeding?


    Metformin may lead to some side effects in breastfeeding women. If you witness any unusal symptoms after taking Metformin, discontinue its use and call your doctor right away. Follow your doctor's advice regarding the use of Metformin.

    Moderate
  • What is the effect of Metformin on the Kidneys?


    Metformin does not damage the kidneys.

    Safe
  • What is the effect of Metformin on the Liver?


    Metformin is completely safe for the liver.

    Safe
  • What is the effect of Metformin on the Heart?


    Metformin is completely safe for the heart.

    Safe


Severe Interaction of Metformin with Other Drugs

Metformin should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate



Metformin Contraindications

If you are suffering from any of the following diseases, you should not take Metformin unless your doctor advises you to do so -



Frequently asked Questions about Metformin

  • Is this Metformin habit forming or addictive?


    Forming a habit of Metformin has not been reported.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    Metformin will not make you feel sleepy or drowsy. So you drive or operate machinery safely.

    Safe
  • Is it safe?


    Yes, but consume Metformin only on doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    Metformin is unable to treat or cure mental disorders.

    No

Metformin Interactions with Food and Alcohol

  • Interaction between Food and Metformin


    Due to a lack of research, nothing can be said about the consequences of taking Metformin together with food.

    Unknown
  • Interaction between Alcohol and Metformin


    Consuming Metformin with alcohol can have many serious effects on your body.

    Severe


Frequently asked Questions about Metformin

Question almost 5 years ago

Does Metformin cause low blood sugar (hypoglycemia)?

Dr. Ramraj MBBS , Other

Yes, Metformin can cause low blood sugar (hypoglycemia). However, this can also occur if you delay or miss a meal, drink alcohol, exercise more than usual, can't eat due to stomach upset, and taking other antidiabetic medicine with metformin. So, regular monitoring of blood glucose level is needed and be cautious of symptoms of hypoglycemia, always keep glucose-rich food with you. 

Question almost 5 years ago

Does Metformin cause sweating?

Dr. Joydeep Sarkar MBBS , Internal Medicine

Yes, Metformin can cause night sweat, the exact mechanism of sweating is not known. But some research suggests that Metformin causes hypoglycemia (low blood sugar) especially at night which can cause night sweats. Need to monitor your blood glucose level regularly, and talk to your doctor as your dose of Metformin may need to be adjusted.

Question over 4 years ago

How does Metformin increase lactic acidosis?

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Metformin treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Metformin induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Question about 5 years ago

How long should I take Metformin for?

Dr. Ram Saini MD, MBBS , General Physician

Metformin can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime. 

Question about 5 years ago

What are the uses of Metformin?

Dr. Haleema Yezdani MBBS , General Physician

Metformin is used with a proper diet and exercise program, to treat diabetes. It is also used with other medication to reduce the high blood sugar. It is used in a patient with type2 diabetes. It is also used in the treatment of polycystic ovarian syndrome (PCOS) and cancer.



See all substitutes for Metformin


This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Glucophage® (metformin hydrochloride)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 275-276

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 825-826

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