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Letrafem, containing the active ingredient Letrozole, is a non-steroidal aromatase inhibitor used primarily in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It works by decreasing estrogen levels, which helps slow or reverse the growth of estrogen-sensitive tumors.
Adjuvant Treatment of Breast Cancer: Early-stage hormone receptor-positive breast cancer in postmenopausal women.
Extended Adjuvant Treatment: After standard tamoxifen therapy.
Advanced Breast Cancer: First-line treatment for hormone receptor-positive or unknown metastatic breast cancer.
Letrozole inhibits the enzyme aromatase, responsible for converting androgens into estrogens. By lowering estrogen levels, it helps reduce the growth of estrogen-dependent cancer cells.
Standard Dosage: 2.5 mg orally once daily, with or without food.
Treatment duration depends on the individual’s response and clinical condition, often continuing until disease progression.
Common side effects:
Hot flashes
Fatigue
Nausea
Increased sweating
Joint pain or stiffness
Serious side effects:
Osteoporosis
Bone fractures
Elevated cholesterol levels
Use with caution in patients with hepatic or renal impairment.
Regular monitoring of bone mineral density is recommended.
Not recommended for premenopausal women or during pregnancy.
Onset: Letrozole begins to lower estrogen levels within hours but clinical benefits may take weeks to become evident.
Duration: Therapeutic effects last as long as the medication is taken continuously.
Store at room temperature, away from moisture and heat.
Letrafem is used to treat the following -
Main Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
| Age Group | Dosage |
| Adult(Female) |
|
| Geriatric |
|
Based on research, the following side effects have been observed when Letrafem is used -
Severe
Mild
Common
Is the use of Letrafem safe for pregnant women?
Letrafem can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.
Is the use of Letrafem safe during breastfeeding?
Taking Letrafem may lead to serious side effects if you are breastfeeding. Letrafem should not be taken by breastfeeding women unless prescribed by the doctor.
What is the effect of Letrafem on the Kidneys?
Letrafem may have mild side effects on the kidneys.
What is the effect of Letrafem on the Liver?
There may be an adverse effect on the liver after taking Letrafem. If you observe any side effects on your body then stop taking this drug. Take this medicine again only if your doctor advises you to do so.
What is the effect of Letrafem on the Heart?
There may be an adverse effect on the heart after taking Letrafem. If you observe any side effects on your body then stop taking this drug. Restart this medicine only if your doctor advises you to do so.
Letrafem should not be taken with following medicines due to severe side effects it may cause to patients -
Severe
Moderate
If you are suffering from any of the following diseases, you should not take Letrafem unless your doctor advises you to do so -
Is this Letrafem habit forming or addictive?
Forming a habit of Letrafem has not been reported.
Is it safe to drive or operate heavy machinery when consuming?
No, you should not drive or operate heavy machinery after taking Letrafem as you may feel sleepy.
Is it safe?
Yes, but consume Letrafem only on doctor's advice.
Is it able to treat mental disorders?
No, Letrafem cannot treat any kind of mental disorder.
Interaction between Food and Letrafem
Due to the absence of research, it is difficult to say how Letrafem and food will interact.
Interaction between Alcohol and Letrafem
Due to lack of research, nothing can be said about side effects of consuming alcohol while taking Letrafem.
Yes, Letrafem and metformin can be taken together because no harmful drug interaction has been reported between them. Hence, it is safe to take Letrafem along with metformin.
No, Letrafem does not cause ovarian cysts. It has not been reported by the patients who are taking this drug. However, the possibility of ovarian cysts formation by this drug because of long-term use in high doses cannot be denied.
Yes, Letrafem is safe to use, if taken in prescribed amount and duration as advised by the doctor. However, certain side effects have been associated with this drug such as sweating, bone pain, and hot flashes. If you experience above-mentioned side after consuming this medicine then inform your doctor and follow his/her instructions.
Take Letrafem once daily or as advised by your doctor. It has been taken with or without food because the presence of food does not affect the absorption of this drug from the stomach. Precautions must be taken in patients with osteoporosis, fracture, and improper liver function.
Letrafem is a brand name of letrozole and it comes in the form of a tablet. It belongs to the class of drugs known as an aromatase inhibitor. It is a prescription drug which is used for the treatment of breast cancer. It is also used off-label for the treatment of anovulation (female infertility).
This medicine data has been created by -
B.Pharma, Pharmacy
7 Years of Experience
References
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 758
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 314-315
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Femara (letrozole)
