Misogen

Yes, [Medcine] has been reported to cause uterine rupture when given only after the eighth week of pregnancy. This occurs in a few cases only. You are advised to report to your doctor immediately if you are experiencing heavy bleeding after taking Misogen.

Yes, Misogen might cause weight gain but it has been infrequently reported. Weight gain has not been directly associated with the use of Misogen. However, if you experience any unusual weight gain after taking this drug then consult it with your doctor.

Misogen contains misoprostol which is a prostaglandin E1 (PGE1) analogue that possesses antisecretory property that inhibits gastric acid secretion. NSAIDs (nonsteroidal anti-inflammatory drugs) inhibits the synthesis of prostaglandins which leads to diminishing bicarbonate and mucus secretion which contributes to ulceration. Misogen has mucosal protective properties that protect the stomach tissues from the damage caused by the stomach acid through decreased acid secretion and mucosal protective action. It induces labour by causing relaxation of cervix uteri (which is the lower part of the uterus). In the treatment of postpartum hemorrhage Misogen works by causing contractions of smooth muscle fibres of the myometrium (middle layer of the uterine wall).

The chances of Misogen to not work are very slim, however if the woman fails to abort within 24 hours after taking the first dose of Misogen and if no significant side effects were observed when a second course of Misogen can be given after 12 hours of the last dose of Misogen.

The dosage of Misogen may vary from case to case and type of condition in which the drug is being given. You are advised to take Misogen as prescribed by your doctor. Ideally, it should be taken with the food to minimize the possibility of stomach irritation that can result in diarrhoea. Precautions must be taken in patients with known inflammatory bowel disease, improper kidney function, coronary artery disease, and hypertension.