Chloramphenicol

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Chloramphenicol Information

Chloramphenicol is a prescription medicine. It is typically used for the treatment of Bacterial Infections. Secondary and off-label uses of Chloramphenicol have also been mentioned below.

The right dosage of Chloramphenicol depends on the age, gender, and medical history of the patient. Individual symptoms and route of administration also determines the right dosage. This information has been provided in detail in the dosage section.

While these are the most often observed Chloramphenicol side effects, there are can be others also. These have been listed below. These side effects of Chloramphenicol are usually temporary and subside with the completion of treatment. However, if these continue for a longer time, consult your doctor right away.

In addition, Chloramphenicol's effect is Severe during pregnancy and Severe for lactating mothers. Further, the section on Chloramphenicol related warnings talks about Chloramphenicol's effects on the liver, heart and kidney.

Individuals suffering from medical conditions like Kidney Disease, Liver Disease must refrain from the use of Chloramphenicol since this can cause severe adverse effects. The section on Chloramphenicol contraindications lists all such conditions.

Additionally, Chloramphenicol may also adversely react with other medicines. See below for a complete list.

In addition to these precautions, you may also note that Chloramphenicol is safe while driving, and is is addictive in nature.



Chloramphenicol Benefits & Uses

Chloramphenicol is used to treat the following -

Main Benefits

Other Benefits

Chloramphenicol Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Typhoid Fever
  • Before or After Meal: After Meal
  • Single Maximum Dose: 12.5 mg/kg
  • Dosage Form: Capsule
  • Dosage Route: Oral
  • Frequency: 6 hourly
  • Course Duration: 10 days
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Typhoid Fever
  • Before or After Meal: After Meal
  • Single Maximum Dose: 12.5 mg/kg
  • Dosage Form: Capsule
  • Dosage Route: Oral
  • Frequency: 6 hourly
  • Course Duration: 10 days
  • Special Instructions: As prescribed by the doctor
13 - 18 years (Adolescent)
  • Disease: Typhoid Fever
  • Before or After Meal: After Meal
  • Single Maximum Dose: 12.5 mg/kg
  • Dosage Form: Capsule
  • Dosage Route: Oral
  • Frequency: 6 hourly
  • Course Duration: 10 days
  • Special Instructions: As prescribed by the doctor


Chloramphenicol Side Effects

Based on research, the following side effects have been observed when Chloramphenicol is used -

Mild

  • Nausea or vomiting
  • Diarrhoea

Chloramphenicol Related Warnings

  • Is the use of Chloramphenicol safe for pregnant women?


    Chloramphenicol can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.

    Severe
  • Is the use of Chloramphenicol safe during breastfeeding?


    Taking Chloramphenicol may lead to serious side effects if you are breastfeeding. Chloramphenicol should not be taken by breastfeeding women unless prescribed by the doctor.

    Severe
  • What is the effect of Chloramphenicol on the Kidneys?


    Very few cases of side effects of Chloramphenicol on kidney have been reported.

    Mild
  • What is the effect of Chloramphenicol on the Liver?


    Chloramphenicol can have moderate side effects on the liver. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate
  • What is the effect of Chloramphenicol on the Heart?


    Chloramphenicol can have moderate side effects on the heart. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate


Severe Interaction of Chloramphenicol with Other Drugs

Chloramphenicol should not be taken with following medicines due to severe side effects it may cause to patients -

Moderate



Chloramphenicol Contraindications

If you are suffering from any of the following diseases, you should not take Chloramphenicol unless your doctor advises you to do so -



Frequently asked Questions about Chloramphenicol

  • Is this Chloramphenicol habit forming or addictive?


    Chloramphenicol is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    Yes, you can comfortably use machinery or drive after taking Chloramphenicol since it will not make you feel sleepy.

    Safe
  • Is it safe?


    Chloramphenicol should be used only after doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Chloramphenicol is not used to treat mental disorders.

    No

Chloramphenicol Interactions with Food and Alcohol

  • Interaction between Food and Chloramphenicol


    Eating certain foods may increase the time it takes Chloramphenicol to have an effect. You should consult your doctor about it.

    Mild
  • Interaction between Alcohol and Chloramphenicol


    It is difficult to say anything about the effect of Chloramphenicol and alcohol. No research has been done on this yet.

    Unknown


Frequently asked Questions about Chloramphenicol

Question over 3 years ago

Can I take Chloramphenicol with paracetamol?

Dr. Roshni Poonja MBBS , General Physician, Internal Medicine

Yes, Chloramphenicol can be taken with paracetamol. No drug-drug interaction has been reported between them. Chloramphenicol is safe to take along with paracetamol if taken as recommended. 

Question over 3 years ago

Can I take Chloramphenicol with ranitidine?

Dr. Chinmaya Bal MBBS , General Physician

Yes, Chloramphenicol can be taken with ranitidine. No harmful drug interaction has been reported between them. It is safe to take Chloramphenicol along with ranitidine if taken as directed by a doctor. However, if you feel any discomfort after taking this drug do not hesitate to inform your doctor.

Question over 4 years ago

Does Chloramphenicol cause fever?

Dr. Kapil Sharma MBBS , General Physician

Yes, Chloramphenicol has been reported to cause fever and chills but this occurs in a few cases. If you are experiencing fever after taking this drug then try taking antipyretics (drugs that reduces fever, such as paracetamol) if the fever relapses again then discuss it with your doctor.

Question almost 5 years ago

Does Chloramphenicol cause weight loss?

Dr. Ajay Kumar. MBBS, MD , Psychiatry, General Physician, Infectious Disease, Sexology, Internal Medicine, Venereology, Diabetology

No, Chloramphenicol does not cause weight loss. It has not been reported by the patients who are taking this drug. However, some of the animal studies have reported weight loss after long-term use of this drug. If you are experiencing unusual weight loss and you are in doubt that Chloramphenicol is causing weight loss then discuss with your doctor instantly. 

Question over 4 years ago

Does Chloramphenicol cover pseudomonas?

Dr. Kishan Barnwal MBBS , General Physician

No, Chloramphenicol does not cover Pseudomonas species. They are generally found to be resistant to Chloramphenicol.



See all substitutes for Chloramphenicol


This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Chloromycetin sodium succinate (chaloramphenicol sodium succinate)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 739-742

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