Sertraline

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Sertraline Information

Sertraline is a prescription medicine. Primarily, it is used for the treatment of Depression, Fear. Secondary and off-label uses of Sertraline have also been mentioned below.

The right dosage of Sertraline depends on the age, gender, and medical history of the patient. Besides the medical condition it is advised for, the route of administration also plays an important role in determining the correct drug dosage. For detailed information on this, read through the dosage section.

While these are the most often observed Sertraline side effects, there are can be others also. These have been listed below. Normally, these side effects of Sertraline are not long lasting and go away when the treatment is finished. Please speak with your doctor if these side effects worsen or persist for a longer duration.

In addition, Sertraline's effect is Moderate during pregnancy and Severe for lactating mothers. Further, the section on Sertraline related warnings talks about Sertraline's effects on the liver, heart and kidney.

Sertraline is not recommended if you suffer from certain medical conditions as it can have adverse effects. Suicidal Tendency, Bipolar Disorder are examples of such conditions. Other conditions have been mentioned below in the Sertraline contraindications section.

Drug reaction of Sertraline with other medicines has been reported. A complete list of these interactions is given below.

In addition to these precautions, you may also note that Sertraline is not safe while driving, and is is not addictive in nature.



Sertraline Benefits & Uses

Sertraline is used to treat the following -

Main Benefits

Other Benefits

Sertraline Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Depression
  • Before or After Meal: After Meal
  • Single Maximum Dose: 50 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
Adult(Female)
  • Disease: PMS
  • Before or After Meal: After Meal
  • Single Maximum Dose: 50 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: Given continuously or during the luteal phase only
Geriatric
  • Disease: Depression
  • Before or After Meal: After Meal
  • Single Maximum Dose: 25 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
13 - 18 years (Adolescent)
  • Disease: Depression
  • Before or After Meal: After Meal
  • Single Maximum Dose: 25 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor

Sertraline Related Warnings

  • Is the use of Sertraline safe for pregnant women?


    Sertraline can cause unwanted side effects in pregnant women. If you experience any side effects, stop taking Sertraline right away. Take your doctor's advice before taking it again.

    Moderate
  • Is the use of Sertraline safe during breastfeeding?


    Women who are breastfeeding, may experience serious side effects after taking Sertraline. So it is adviced to consult the doctor before using it.

    Severe
  • What is the effect of Sertraline on the Kidneys?


    Sertraline is not harmful for kidneys.

    Safe
  • What is the effect of Sertraline on the Liver?


    Sertraline may have mild side effects on the liver. Most people will never see any effect on the liver.

    Mild
  • What is the effect of Sertraline on the Heart?


    Side effects of Sertraline rarely affect the heart.

    Mild


Severe Interaction of Sertraline with Other Drugs

Sertraline should not be taken with following medicines due to severe side effects it may cause to patients -

Severe



Sertraline Contraindications

If you are suffering from any of the following diseases, you should not take Sertraline unless your doctor advises you to do so -



Frequently asked Questions about Sertraline

  • Is this Sertraline habit forming or addictive?


    Sertraline is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    You may feel sleepy or tired after taking Sertraline. So it is best to avoid driving.

    Dangerous
  • Is it safe?


    Yes, but consume Sertraline only on doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    Yes, Sertraline is useful in treating mental disorders.

    Yes

Sertraline Interactions with Food and Alcohol

  • Interaction between Food and Sertraline


    Taking Sertraline with food does not cause any problems.

    Safe
  • Interaction between Alcohol and Sertraline


    Taking alcohol with Sertraline can be dangerous.

    Severe


Frequently asked Questions about Sertraline

Question over 4 years ago

Can Sertraline cause sexual dysfunction?

Dr. Rahul Poddar MBBS, DNB, MBBS, DNB , General Surgery

Rarely, Sertraline causes erectile dysfunction. It is an uncommon side effect of this drug. However, the exact cause of erectile dysfunction is unknown. If you experience erectile dysfunction after taking this drug. Do not hesitate to discuss with your doctor. If need be discontinued the drug after taking doctors consent.

Question almost 5 years ago

Does Sertraline make you high?

Dr Anjum Mujawar MBBS, MBBS , Emergency Medicine

No, Sertraline doesn't make one feel high. It is a selective serotonin reuptake inhibitor which improves depression symptoms by increasing the concentration of serotonin in the brain.

Question almost 5 years ago

Can Sertraline cause weight fluctuation?

Dr. Ramraj Meena MBBS , General Physician

Yes, Sertraline can cause weight fluctuation (weight gain and loss). It is a common side effect of this drug. Few people may experience this effect after consuming this drug. People should monitor their weight, eat healthily and include at least 30 mins of exercising in a day. In spite of all efforts if you experience weight fluctuation then discuss with your doctor. 

Question almost 5 years ago

Can Sertraline cause insomnia?

Dr. Rahul Poddar MBBS, DNB, MBBS, DNB , General Surgery

Rarely, Sertraline causes insomnia. It is an uncommon side effect of this drug. To tackle this your doctor may switch your medications or lower its dosage.

Question over 4 years ago

Does Sertraline cause sweating?

Dr. Braj Bhushan Ojha BAMS , Gastroenterology, Dermatology, Psychiatry, Ayurveda, Sexology, Diabetology

Yes, Sertraline may cause sweating but it occurs only in a few cases. It is a rare side effect of this drug. However, the exact cause of sweating is unknown but it is presumed that sweating occurs due to stimulation of sweat glands which causes excess sweating.



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This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Zoloft (sertraline hydrochloride)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 461

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1132-1134

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