Markzole

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  • Contains / Salt: Fluconazole (150 mg)
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Markzole Information

Markzole, a prescription drug, is manufactured in various forms such as Tablet. Primarily, it is used for the treatment of Fungal Infections, Candidal Infection, Urinary Tract Infection. Secondary and off-label uses of Markzole have also been mentioned below.

The optimal dosage of Markzole is largely dependent on the individual's body weight, medical history, gender and age. Individual symptoms and route of administration also determines the right dosage. Refer to the dosage section for a detailed discussion.

Apart from the aforementioned side effects, Markzole can also lead to other problems, which have been listed below. Normally, these side effects of Markzole are not long lasting and go away when the treatment is finished. Consult your doctor if these side effects become worse or stay for a longer duration.

In addition, Markzole's effect is Severe during pregnancy and Safe for lactating mothers. Further, the section on Markzole related warnings talks about Markzole's effects on the liver, heart and kidney.

Markzole is not recommended if you suffer from certain medical conditions as it can have adverse effects. Liver Disease are examples of such conditions. Other conditions have been mentioned below in the Markzole contraindications section.

Drug interactions for Markzole have been reported in the medical literature. See below for a complete list.

You should also be aware that Markzole is not safe while driving, and is not addiction.



Markzole Benefits & Uses

Markzole is used to treat the following -

Other Benefits

Markzole Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult(Female)
  • Disease: Vaginal Yeast Infection
  • Before or After Meal: After Meal
  • Single Maximum Dose: 150 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 3 days
  • Special Instructions: Then once a week for 6 months
Adult
  • Disease: Fungal Infections
  • Before or After Meal: After Meal
  • Single Maximum Dose: 400 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 1 days
  • Special Instructions: Then 200 - 800 mg/day for 28 days
Geriatric
  • Disease: Fungal Infections
  • Before or After Meal: After Meal
  • Single Maximum Dose: 400 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 1 days
  • Special Instructions: Then 200 - 800 mg/day for 28 days
13 - 18 years (Adolescent)
  • Disease: Fungal Infections
  • Before or After Meal: After Meal
  • Single Maximum Dose: 12 mg/kg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 4 weeks
  • Special Instructions: As prescribed by the doctor
2 - 12 years (Child)
  • Disease: Fungal Infections
  • Before or After Meal: After Meal
  • Single Maximum Dose: 6 mg/kg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 4 weeks
  • Special Instructions: As prescribed by the doctor


Markzole Side Effects

Based on research, the following side effects have been observed when Markzole is used -

Severe

  • Angioedema
  • Anaphylactic reaction
  • Seizures (uncontrollable jerking of limbs)
  • Steven-johnsons syndrome

Moderate

Mild

Markzole Related Warnings

  • Is the use of Markzole safe for pregnant women?


    Markzole has many dangerous side effects in pregnant women. If you are pregnant, do not consume Markzole without medical advice.

    Severe
  • Is the use of Markzole safe during breastfeeding?


    Markzole does not show any side effects in breastfeeding women.

    Safe
  • What is the effect of Markzole on the Kidneys?


    Markzole may cause harmful effects on kidney. if you feel its having any such effect, then stop taking this drug, and restart only on your doctor's advice.

    Moderate
  • What is the effect of Markzole on the Liver?


    Markzole has very mild side effects on the liver.

    Mild
  • What is the effect of Markzole on the Heart?


    Very few cases of side effects of Markzole on the heart have been reported.

    Mild


Severe Interaction of Markzole with Other Drugs

Markzole should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate

Mild



Markzole Contraindications

If you are suffering from any of the following diseases, you should not take Markzole unless your doctor advises you to do so -



Frequently asked Questions about Markzole

  • Is this Markzole habit forming or addictive?


    Markzole is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should do not do anything that requires concentration and attention as the Markzole can make you feel drowsy.

    Dangerous
  • Is it safe?


    Markzole should be used only after doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Markzole cannot treat any kind of mental disorder.

    No

Markzole Interactions with Food and Alcohol

  • Interaction between Food and Markzole


    Taking Markzole with food is safe.

    Safe
  • Interaction between Alcohol and Markzole


    It is difficult to say anything about the effect of Markzole and alcohol. No research has been done on this yet.

    Unknown


Frequently asked Questions about Markzole

Question about 5 years ago

Can I discontinue Markzole on my own or without doctors advice?

Dr. Anand Singh MBBS , General Physician

Discontinuation of Markzole on your own can cause unwanted side effects such as a headache, dizziness, stomach upset, and diarrhea. You are recommended to always consult a doctor before discontinuing this medicine.

Question over 4 years ago

Does Markzole treat jock itch?

Dr. MBBS , General Physician, Other, Obstetrics & Gynaecology

Yes, Markzole is widely used in the treatment of jock itch (tinea cruris). It is a prescription medicine so please consult your doctor before using this medication for tinea cruris.

Question over 4 years ago

Does Markzole cause constipation?

Dr. Suhas Bhargav MBBS , General Physician

Occasionally, Markzole causes constipation when it is taken orally, while the interavenous administration of the medication does not cause constipation or other stomach related issues.

Question over 4 years ago

Can Markzole cause irregular period?

Dr. Roshni Poonja MBBS , General Physician, Internal Medicine

Rarely, Markzole can cause irregular periods. However, if you're experiencing conditions such as leucorrhoea (whitish or yellowish vaginal discharge), menorrhagia (abnormally heavy bleeding at menstruation) and dysmenorrhea (Painful periods) after taking this medication. Inform your doctor and see a gynaecologist.

Question about 5 years ago

How does Markzole work?

Dr. Manoj Meena MBBS , General Physician

Markzole inhibit the fungal cytochrome P450 enzyme lanosterol 14- demethylase and thus block ergosterol synthesis leading to membrane abnormalities in the fungus. It kills the fungus by destroying its cell membrane.



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This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Diflucan® (fluconazole)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 793-794

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