Proval

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Proval Information

Proval is a commercial drug that is prescribed in the form of Tablet. It is typically used for the treatment of Epilepsy, Migraine. Other than this, Proval has some other therapeutic uses, which have been discussed ahead.

The correct dosage of Proval depends on the patient's age, gender, and medical history. Besides the medical condition it is advised for, the route of administration also plays an important role in determining the correct drug dosage. Detailed information has been provided in the dosage section.

While these are the most often observed Proval side effects, there are can be others also. These have been listed below. Such side effects of Proval normally do not last long and go away once the treatment is completed. However, if these continue for a longer time, consult your doctor right away.

Furthermore, you should know that effect of Proval is Severe for pregnant women and Mild for women who are breastfeeding. It is important to know if Proval has any effect on the kidney, liver and heart. Information on such adverse effects, if any, has been given in the Proval related warnings section.

Individuals suffering from medical conditions like Depression, Liver Disease must refrain from the use of Proval since this can cause severe adverse effects. The section on Proval contraindications lists all such conditions.

Drug reaction of Proval with other medicines has been reported. See below for a complete list.

Along with the above-mentioned precautions, remember that taking Proval is considered not safe while driving, and is not addictive.


Proval Benefits & Uses

Proval is used to treat the following -

Main Benefits

Other Benefits

Proval Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Epilepsy
  • Before or After Meal: After Meal
  • Single Maximum Dose: 5 mg/kg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 3 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: Dose can be increased by 5 - 10 mg /kg/day every week until seizures are controlled.
13 - 18 years (Adolescent)
  • Disease: Epilepsy
  • Before or After Meal: After Meal
  • Single Maximum Dose: 5 mg/kg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 3 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: Dose can be increased by 5 - 10 mg /kg/day every week until seizures are controlled
Geriatric
  • Disease: Mania
  • Before or After Meal: After Meal
  • Single Maximum Dose: 250 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 3 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: delayed-release tablet

Proval Related Warnings

  • Is the use of Proval safe for pregnant women?


    Proval should not be taken during pregnancy, or should only be taken on the advice of a doctor as it may have severe side effects.

    Severe
  • Is the use of Proval safe during breastfeeding?


    Proval may have very limited harmful effects for breastfeeding women.

    Mild
  • What is the effect of Proval on the Kidneys?


    Proval rarely affects the kidneys.

    Mild
  • What is the effect of Proval on the Liver?


    Proval may have mild side effects on the liver. Most people will never see any effect on the liver.

    Mild
  • What is the effect of Proval on the Heart?


    Using Proval does not have any harmful effects on the heart.

    Safe

Severe Interaction of Proval with Other Drugs

Proval should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate

Mild


Proval Contraindications

If you are suffering from any of the following diseases, you should not take Proval unless your doctor advises you to do so -


Frequently asked Questions about Proval

  • Is this Proval habit forming or addictive?


    No, there is no any evidence that Proval is addictive.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should not drive or operate heavy machinery after taking Proval as you may feel sleepy.

    Dangerous
  • Is it safe?


    Proval is safe but it is important to consult a doctor before taking it.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    Yes, Proval is useful in treating mental disorders.

    Yes

Proval Interactions with Food and Alcohol

  • Interaction between Food and Proval


    Taking Proval with food is safe.

    Safe
  • Interaction between Alcohol and Proval


    Consumption of alcohol and Proval together may have severe effects on your health.

    Severe

Frequently asked Questions about Proval

Question over 5 years ago

How does Proval work?

Dr. Manoj Meena MBBS , General Physician

Proval works by relaxing the muscles of the body and suppressing abnormal activity of nerve cells in the brain through an increase in activity of a chemical messenger known as GABA (gamma-aminobutyric acid) by inhibiting the enzymes which are responsible for its decreased concentration of GABA in the brain. In this way Proval provides Thus, relief from the seizure and mania associated with bipolar disorder.

Question over 5 years ago

What is Proval?

Dr. Saurabh Shakya MBBS , General Physician

Proval is a brand name for divalproex. It is a prescription drug that belongs to the class of drug called anti-epileptic drug, also known as an anticonvulsant and anti-seizure medication. It is used in the treatment of epilepsy (seizure). Proval is also used to treat mania associated with bipolar disorder and to prevent episodes of migraine headache. 

Question about 5 years ago

Can I take Proval with tramadol?

Dr. Mayank Yadav MBBS , General Physician

Yes, you can take Proval with tramadol only on your doctor's advice because taking these drugs together might cause increase the risk of side effects such as difficulty concentrating, drowsiness, and confusion.

Question about 5 years ago

Can Proval cause depression?

Dr. Sangita Shah MBBS , General Physician

Yes, Proval may cause depression of the central nervous system by increasing the effects of an inhibitory neurotransmitter GABA.

Question almost 5 years ago

Does Proval cause erectile dysfunction?

Dr. Bharat MBBS , General Physician

Yes, Proval causes erectile dysfunction. If you experience erectile dysfunction after taking this drug then do not stop the drug without consulting your doctor. Discuss it with your doctor, he/she will provide you with solutions or prescribe alternative medicines.


See all substitutes for Proval


This medicine data has been created by -

Vikas Chauhan
B.Pharma, Pharmacy
5 Years of Experience

References

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 418

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Depakote (divalproex sodium)

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Depakote Er (divalproex sodium)


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