What is Aspergillus Antibodies test?

Aspergillus is a common mould that grows on soil, dead leaves, stagnant water or plants that grow close to the ground. It forms tiny black spores, which can remain floating in the air and enter people’s respiratory tracts. Usually, this kind of entry does not cause a problem as our immune system is efficient in protecting us from infections. However, in case someone has a weak immune system, the fungus can end up in their lungs and cause severe infection. In some cases, the person may also develop an allergic reaction to Aspergillus.

The Aspergillus antibodies test checks for the presence of antibodies against Aspergillus infection in the body. It is done to know if a person has an Aspergillus infection currently or had one in the past. Antibodies are immune system proteins that fight invading pathogens or toxins. Our body produces a different antibody against every toxin or pathogen.

This test usually checks for two types of antibodies, IgG and IgE, which are found in our blood. It looks for three kinds of Aspergillus fungi: A. flavus, A. niger and A. fumigatus. Most commonly, the test is used to detect the IgG antibody to A. fumigatus.

  1. Why is an Aspergillus Antibodies test performed?
  2. How do you prepare for an Aspergillus Antibodies test?
  3. How is an Aspergillus Antibodies test performed?
  4. What do Aspergillus Antibodies test results mean?

This test is mainly ordered for diagnosing Aspergillus allergy or infection. It may also be ordered to manage or know the progress of the prescribed treatment. Following is a list of symptoms common to most Aspergillus allergy or infections:

Some other symptoms may also include wheezing, difficulty in exercising, recurring fever and chest pain or tightness.

Your doctor might order an Aspergillus antibodies panel if you have had the above-mentioned symptoms for more than three months.

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Usually, an Aspergillus antibodies panel involves the use of a blood sample. Therefore, not much preparation is required before the test. It is essential to inform the doctor about your past work and travel history before any fungal test process as this can lead to better diagnosis of the disease. If you have any doubts about the test, you can speak to your doctor before the procedure.

A technician or nurse will withdraw a small amount of blood from a vein in your arm using a sterilised needle. As they withdraw blood, you may feel a stinging sensation on the skin. However, this will go away on its own.

Some people observe slight bruising on the skin at the site from where the blood was taken. It usually disappears in some time. In case it does not fade away soon, please consult your doctor.

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Normal results:

A normal result in case of Aspergillus antibodies panel is reported as negative. It means that there are no antibodies in the blood sample or the number of antibodies is too low to be significant. It could indicate that the person does not have an allergy or an infection in most cases. However, a negative result does not eliminate the chances of occurrence of the condition called aspergillosis - a respiratory infection caused due to aspergillus.

Abnormal results:

An abnormal result in the case of this test is reported as positive. It means that some antibodies against Aspergillus have been detected in the blood sample. The laboratory may be able to report the severity of the detection. Your doctor will be able to explain the results better. A few diseases associated with the presence of antibodies against Aspergillus are as follows:

Antibody detected Possible Disorders
IgG antibody Aspergilloma caused by A.fumigatus, chronic pulmonary aspergillosis or fungal sinusitis caused by A.flavus
IgE antibody Aspergillus rhinosinusitis caused by A.fumigatus
Low levels of IgG (high levels might be linked to complications) and positive IgE, IgA and IgM Allergic bronchopulmonary aspergillosis
Presence of IgG and absence of IgE Aspergillus bronchitis

Usually, the presence of IgG in the sample is also associated with a past infection of the fungi.

The doctor will be able to explain the severity of the result and provide you with the most appropriate treatment. They may also need you to undergo other tests to confirm the diagnosis. They may even need to repeat the test when they begin the treatment as it may take many months to show improvement. Therefore, testing again during the process would clarify whether the treatment is effective or not.

Disclaimer: All results must be clinically correlated with the patient’s complaints to make a complete and accurate diagnosis. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor.

References

  1. State Hygienic Laboratory: University of Iowa [internet]. IA (U.S.A). Aspergillus Antibody Panel
  2. American Thoracic Society [internet]. NY (U.S.A). What Is Allergic Bronchopulmonary Aspergillosis (ABPA)?
  3. Wilson DD. McGraw-Hill’s Manual of Laboratory & Diagnostic Tests. McGraw Hill. 2008. Pp:270-272.
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