Disulfiram

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Disulfiram Information

Disulfiram, a prescription drug, is manufactured in various forms such as Tablet. Primarily, it is used for the treatment of Alcoholism.

The optimal dosage of Disulfiram is largely dependent on the individual's body weight, medical history, gender and age. Besides the medical condition it is advised for, the route of administration also plays an important role in determining the correct drug dosage. Detailed information has been provided in the dosage section.

Some other side effects of Disulfiram have been listed ahead. These side effects of Disulfiram are usually temporary and subside with the completion of treatment. Please speak with your doctor if these side effects worsen or persist for a longer duration.

In addition, Disulfiram's effect is Moderate during pregnancy and Severe for lactating mothers. It is important to know if Disulfiram has any effect on the kidney, liver and heart. Information on such adverse effects, if any, has been given in the Disulfiram related warnings section.

Disulfiram is not recommended if you suffer from certain medical conditions as it can have adverse effects. Heart Disease, Psychosis are examples of such conditions. Other contraindications of Disulfiram have been discussed in the sections ahead.

Drug reaction of Disulfiram with other medicines has been reported. A complete list of these interactions is given below.

In addition to these precautions, you may also note that Disulfiram is not safe while driving, and is is not addictive in nature.



Disulfiram Benefits & Uses

Disulfiram is used to treat the following -

Main Benefits

Disulfiram Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Alcoholism
  • Before or After Meal: After Meal
  • Single Maximum Dose: 500 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 2 weeks
  • Special Instructions: Later decrease dose up to 250 mg once daily, dosage regime: from months to years
Geriatric
  • Disease: Alcoholism
  • Before or After Meal: After Meal
  • Single Maximum Dose: 500 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 2 weeks
  • Special Instructions: Later decrease dose up to 250 mg once daily, dosage regime: from months to years

Disulfiram Related Warnings

  • Is the use of Disulfiram safe for pregnant women?


    Disulfiram may cause moderate side effects during pregnancy. If you feel its harmful effects, then stop taking this drug immediately, and do not take Disulfiram again without your doctor's advice.

    Moderate
  • Is the use of Disulfiram safe during breastfeeding?


    Taking Disulfiram may lead to serious side effects if you are breastfeeding. Disulfiram should not be taken by breastfeeding women unless prescribed by the doctor.

    Severe
  • What is the effect of Disulfiram on the Kidneys?


    Disulfiram may have mild side effects on the kidneys.

    Mild
  • What is the effect of Disulfiram on the Liver?


    Disulfiram may have mild side effects on the liver. Most people will never see any effect on the liver.

    Mild
  • What is the effect of Disulfiram on the Heart?


    Very few cases of side effects of Disulfiram on the heart have been reported.

    Mild


Severe Interaction of Disulfiram with Other Drugs

Disulfiram should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate

Mild



Disulfiram Contraindications

If you are suffering from any of the following diseases, you should not take Disulfiram unless your doctor advises you to do so -



Frequently asked Questions about Disulfiram

  • Is this Disulfiram habit forming or addictive?


    Disulfiram is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should not drive or operate heavy machinery after taking Disulfiram as you may feel sleepy.

    Dangerous
  • Is it safe?


    Yes, but consume Disulfiram only on doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, the use of Disulfiram in mental disorders is not effective.

    No

Disulfiram Interactions with Food and Alcohol

  • Interaction between Food and Disulfiram


    Taking Disulfiram with food is safe.

    Safe
  • Interaction between Alcohol and Disulfiram


    Taking alcohol with Disulfiram can be dangerous.

    Severe


Frequently asked Questions about Disulfiram

Question almost 5 years ago

Can Disulfiram cure alcoholism?

Dr. Suhas Bhargav MBBS , General Physician

No, Disulfiram does not cure alcoholism, but discourages an alcoholic person not to drink in excess by causing undesirable effects even when small amounts of alcohol are consumed.

Question over 4 years ago

Does Disulfiram cause memory loss?

Dr. Suhas Bhargav MBBS , General Physician

No, Disulfiram does not cause any memory loss. However, if you are in doubt that this drug causing memory loss then discuss with your doctor without any hesitation.

Question almost 5 years ago

Does Disulfiram cause constipation?

Dr. MBBS , General Physician, Other, Obstetrics & Gynaecology

No, Disulfiram does not cause constipation in patients who are taking it. However, if you are experiencing constipation after taking this drug then inform your doctor and take precautionary methods such as eating fibrous foods to avoid constipation.

Question about 5 years ago

How to take Disulfiram?

Dr. Piyush Malav MBBS, MS , General Surgery

Disulfiram comes in form of tablet and it should be taken by mouth once daily or as advised by your doctor. Precautions must be taken in patients with diabetes, epilepsy, respiratory disorders, cerebral damage, hypothyroidism, and in people with impaired liver or kidney function. Do not drive any vehicle or operate machinery after taking this medicine as it can cause drowsiness or sedation. Also avoid sauces, vinegars, all foods, beverages and medicines such as cough syrup containing alcohol while taking disulfiram to experience best results with minimal side effects. 
 

Question about 5 years ago

Can I take Disulfiram without consulting a doctor?

Dr. MBBS , General Physician, Other, Obstetrics & Gynaecology

Take Disulfiram as advised by your doctor. Do not discontinue the drug suddenly or take it longer than prescribed by your doctor.



See all substitutes for Disulfiram


This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 394

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Antabuse® (disulfiram)



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