Metformin + Ursodiol (Ursodeoxycholic Acid)

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Metformin + Ursodiol (Ursodeoxycholic Acid) treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Metformin + Ursodiol (Ursodeoxycholic Acid) induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Sameer Awadhiya MBBS , Pediatrics

Metformin + Ursodiol (Ursodeoxycholic Acid) increases the sensitivity of insulin, young women with PCOS often have elevated insulin levels and are more likely to develop diabetes. It is often prescribed for women with PCOS to help prevent diabetes. A lifestyle that includes healthy nutrition and daily exercise is the most important part of a PCOS treatment plan.

Dr. Joydeep Sarkar MBBS , Internal Medicine

Yes, Metformin + Ursodiol (Ursodeoxycholic Acid) can cause night sweat, the exact mechanism of sweating is not known. But some research suggests that Metformin + Ursodiol (Ursodeoxycholic Acid) causes hypoglycemia (low blood sugar) especially at night which can cause night sweats. Need to monitor your blood glucose level regularly, and talk to your doctor as your dose of Metformin + Ursodiol (Ursodeoxycholic Acid) may need to be adjusted.

Dr. Ayush Pandey MBBS, PG Diploma , General Physician

Yes, Metformin + Ursodiol (Ursodeoxycholic Acid) can cause some sleep problems, especially insomnia. On the other hand, Metformin + Ursodiol (Ursodeoxycholic Acid) has proven to be useful for preventing sleep apnea. The exact relationship between Metformin + Ursodiol (Ursodeoxycholic Acid) and sleep problems is still not clear, and further studies are needed for a clearer understanding.

Dr. Manju Shekhawat MBBS , General Physician

No, you should not take alcohol with Metformin + Ursodiol (Ursodeoxycholic Acid), because it can cause serious side effects which includes hypoglycemia (low blood sugar). The risk of hypoglycemia is higher when you're drinking and taking Metformin + Ursodiol (Ursodeoxycholic Acid) than if you're just taking Metformin + Ursodiol (Ursodeoxycholic Acid). Some of the signs of hypoglycemia include dizziness, confusion, and drowsiness.