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Clozapine

Clozapine Information

Clozapine Benefits & Uses

Clozapine is used to treat the following -

Clozapine Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

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Ingredients of Clozapine

Clozapine

Clozapine Side Effects

Based on research, the following side effects have been observed when Clozapine is used -

  1. Weight gain
  2. Blurred vision
  3. Constipation Moderate
  4. Dizziness Mild
  5. Increased saliva production
  6. Rapid heart rate (pulse)
  7. Orthostatic Hypotension (Sudden Lowering of Blood Pressure on Standing)
  8. Irritability
  9. Back Pain Mild
  10. Fatigue Mild
  11. Diarrhoea
  12. Restlessness
  13. Agitation
  14. Drowsiness
  15. Nausea or vomiting

Clozapine Related Warnings

Is the use of Clozapine safe for pregnant women?

Clozapine has mild to no side effects in pregnant women.

Mild

Is the use of Clozapine safe during breastfeeding?

Clozapine should not be taken without taking your doctor's advice, as it may have severe side effects on breastfeeding women.

Severe

What is the effect of Clozapine on the Kidneys?

Clozapine rarely affects the kidneys.

Mild

What is the effect of Clozapine on the Liver?

Clozapine has very mild side effects on the liver.

Mild

What is the effect of Clozapine on the Heart?

You may experience side effects on your heart after taking Clozapine. If this happens, then discontinue its use. Consult your medical practitioner, and do as he/she suggests.

Moderate

Severe Interaction of Clozapine with Other Drugs

Clozapine should not be taken with following medicines due to severe side effects it may cause to patients -

Acarbose

Chlorpheniramine,Dextromethorphan,Paracetamol,Phenylephrine

    Paracetamol,Tramadol

      Clozapine Contraindications

      If you are suffering from any of the following diseases, you should not take Clozapine unless your doctor advises you to do so -

      1. Bradycardia (Slow Heart Rate)
      2. Heart Disease
      3. Tardive Dyskinesia
      4. Depression
      5. Parkinson's Disease
      6. Neuroleptic Malignant Syndrome
      7. Dementia
      8. Liver Disease

      Frequently asked Questions about Clozapine

      Is this Clozapine habit forming or addictive?

      Clozapine does not cause addiction.

      No

      Is it safe to drive or operate heavy machinery when consuming?

      After taking Clozapine, you should not drive or work on any heavy machine, as Clozapine can make you drowsy.

      Dangerous

      Is it safe?

      Clozapine should be used only after doctor's advice.

      Safe, but take only on Doctor's advise

      Is it able to treat mental disorders?

      Yes, taking Clozapine can treat mental disorders.

      Yes

      Clozapine Interactions with Food and Alcohol

      Interaction between Food and Clozapine

      Clozapine may take longer to act if you eat some foods while taking it. Follow your doctor's advice on this.

      Mild

      Interaction between Alcohol and Clozapine

      Taking Clozapine with alcohol can have severely harmful effects on your health.

      Severe
      This medicine data has been created by -
      Dr. Md Saadullah
      M.Pharma, Pharmacy
      3 Years of Experience
      View Doctor Profile
      Dr. Vikas Chauhan
      B.Pharma, Pharmacy
      2 Years of Experience
      View Doctor Profile

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      References

      1. US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Clozaril® (clozapine)
      2. KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 175,471
      3. April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 56-58