Janumet 500 Tablet

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  • Contains / Salt: Metformin + Sitagliptin
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Janumet 500 Tablet Information

Janumet 500 Tablet, a prescription drug, is manufactured in various forms such as Tablet. Primarily, it is used for the treatment of Diabetes. Other than this, Janumet 500 Tablet has some other therapeutic uses, which have been discussed ahead.

The correct dosage of Janumet 500 Tablet depends on the patient's age, gender, and medical history. The condition it has been prescribed for, and the route of administration also determine the right dosage. For detailed information on this, read through the dosage section.

Common side effects of Janumet 500 Tablet include Nausea or vomiting, Headache, Diarrhoea. Some other side effects of Janumet 500 Tablet have been listed ahead. Usually, these side effects of Janumet 500 Tablet go away soon, and do not persist beyond the duration of the treatment. However, if these continue for a longer time, consult your doctor right away.

It is also important to note that Janumet 500 Tablet has a Mild effect for pregnant women and Safe effect on lactating mothers. It is important to know if Janumet 500 Tablet has any effect on the kidney, liver and heart. Information on such adverse effects, if any, has been given in the Janumet 500 Tablet related warnings section.

Janumet 500 Tablet is not recommended if you suffer from certain medical conditions as it can have adverse effects. Pancreatitis are examples of such conditions. Other contraindications of Janumet 500 Tablet have been discussed in the sections ahead.

Drug interactions for Janumet 500 Tablet have been reported in the medical literature. See below for a complete list.

In addition to these precautions, you may also note that Janumet 500 Tablet is not safe while driving, and is is not addictive in nature.



Janumet 500 Tablet Benefits & Uses

Janumet 500 Tablet is used to treat the following -

Main Benefits

Other Benefits

  • Diabetes Type 2

Janumet 500 Tablet Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Diabetes Type 2
  • Before or After Meal: With meal
  • Single Maximum Dose: 1 Tablet
  • Dosage Form: Tablet (Immediate Release)
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: strength 50 mg sitagliptin and 500 mg metformin
Geriatric
  • Disease: Diabetes Type 2
  • Before or After Meal: With meal
  • Single Maximum Dose: 1 Tablet
  • Dosage Form: Tablet (Immediate Release)
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: strength 50 mg sitagliptin and 500 mg metformin

Janumet 500 Tablet Related Warnings

  • Is the use of Janumet 500 Tablet safe for pregnant women?


    Janumet has little to no side effects in pregnant women.

    Mild
  • Is the use of Janumet 500 Tablet safe during breastfeeding?


    Janumet is safe for breastfeeding women.

    Safe
  • What is the effect of Janumet 500 Tablet on the Kidneys?


    There may be some adverse effects on kidney after taking Janumet. If you observe any such side effects, stop taking this drug. Consume this medicine again only if your doctor advises you to do so.

    Moderate
  • What is the effect of Janumet 500 Tablet on the Liver?


    Janumet is completely safe for the liver.

    Safe
  • What is the effect of Janumet 500 Tablet on the Heart?


    Side effects of Janumet on heart are unknown because research on this has not been conducted yet.

    Unknown


Janumet 500 Tablet Contraindications

If you are suffering from any of the following diseases, you should not take Janumet 500 Tablet unless your doctor advises you to do so -



Frequently asked Questions about Janumet 500 Tablet

  • Is this Janumet 500 Tablet habit forming or addictive?


    Janumet 500 Tablet is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should do not do anything that requires concentration and attention as the Janumet 500 Tablet can make you feel drowsy.

    Dangerous
  • Is it safe?


    Janumet 500 Tablet is safe but it is important to consult a doctor before taking it.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Janumet 500 Tablet is not used to treat mental disorders.

    No

Janumet 500 Tablet Interactions with Food and Alcohol

  • Interaction between Food and Janumet 500 Tablet


    There is no information on the effects of taking Janumet 500 Tablet with food, because this topic has not been scientifically researched yet.

    Unknown
  • Interaction between Alcohol and Janumet 500 Tablet


    No research has been done on this till date. Therefore, it is not known what the effect of taking Janumet 500 Tablet with alcohol will be.

    Unknown


Frequently asked Questions about Janumet 500 Tablet

Question about 5 years ago

How does Janumet work?

Dr. Rahul Poddar MBBS, DNB, MBBS, DNB , General Surgery

Janumet works by decreasing the hepatic glucose production. It also works to lower blood sugar by increasing your sensitivity to insulin and decreasing the amount of glucose that is absorbed from the food you eat.

Question almost 5 years ago

Does Janumet cause sleep problems?

Dr. Ayush Pandey MBBS, PG Diploma , General Physician

Yes, Janumet can cause some sleep problems, especially insomnia. On the other hand, Janumet has proven to be useful for preventing sleep apnea. The exact relationship between Janumet and sleep problems is still not clear, and further studies are needed for a clearer understanding.

Question about 5 years ago

How long should I take Janumet for?

Dr. Ram Saini MD, MBBS , General Physician

Janumet can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime. 

Question over 4 years ago

How does Janumet increase lactic acidosis?

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Janumet treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Janumet induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Question almost 5 years ago

Can I take Janumet with statin?

Dr. R.K Singh MBBS , Diabetology

Yes, Janumet can be taken with the statin. There is no serious or harmful interaction have been observed between them. Some studies say that it's possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.



See all substitutes for Janumet



This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience



References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Glucophage® (metformin hydrochloride)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 275-276

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 825-826

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Januvia® (sitagliptin)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 274-275

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1143-1144

EPAR summary for the public [Internet]: Janumet sitagliptin / metformin hydrochloride. EMA/370017/2013 EMEA/H/C/000861

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