Dr. Ashish Mishra MBBS , Pathology

Yes, you can take X Met P with gliclazide, no harmful interactions have been reported between them. However, it is not necessary that no interaction can happen between these two. But before taking such kind of combination you must consult your doctor.

Dr. Sameer Awadhiya MBBS , Pediatrics

X Met P increases the sensitivity of insulin, young women with PCOS often have elevated insulin levels and are more likely to develop diabetes. It is often prescribed for women with PCOS to help prevent diabetes. A lifestyle that includes healthy nutrition and daily exercise is the most important part of a PCOS treatment plan.

Dr. Bharat MBBS , General Physician

The long-term use can lead to the deficiency of Vitamin B12, which can further lead to megaloblastic anemia. Furthermore, Long-term Metformin use can also lead to kidney and liver problems. 

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with X Met P treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of X Met P induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Ramraj MBBS , Other

Yes, X Met P can cause low blood sugar (hypoglycemia). However, this can also occur if you delay or miss a meal, drink alcohol, exercise more than usual, can't eat due to stomach upset, and taking other antidiabetic medicine with metformin. So, regular monitoring of blood glucose level is needed and be cautious of symptoms of hypoglycemia, always keep glucose-rich food with you.