Zanofiram

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  • Contains / Salt: Disulfiram (250 mg)
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Zanofiram Information

Zanofiram is a prescription medicine that is available as a Tablet. It is primarily used for the treatment of Alcoholism.

The right dosage of Zanofiram depends on the age, gender, and medical history of the patient. Dosage also depends on the route of administration and your chief complaint for which the drug is prescribed. For detailed information on this, read through the dosage section.

Besides the aforementioned side effects, there are other adverse effects of Zanofiram as well, which are listed below. Normally, these side effects of Zanofiram are not long lasting and go away when the treatment is finished. If, however, they worsen or do not go away, please speak with your physician.

Furthermore, you should know that effect of Zanofiram is Moderate for pregnant women and Severe for women who are breastfeeding. In addition, Zanofiram's effects on the liver, heart and kidney are discussed below in the Zanofiram related warnings section.

Zanofiram is contraindicated in people with pre-existing medical conditions like Heart Disease, Psychosis as it can result in adverse effects. Other conditions have been mentioned below in the Zanofiram contraindications section.

Drug reaction of Zanofiram with other medicines has been reported. See below for a complete list.

In addition to these precautions, you may also note that Zanofiram is not safe while driving, and is is not addictive in nature.



Zanofiram Benefits & Uses

Zanofiram is used to treat the following -

Main Benefits

Zanofiram Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Alcoholism
  • Before or After Meal: After Meal
  • Single Maximum Dose: 500 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 2 weeks
  • Special Instructions: Later decrease dose up to 250 mg once daily, dosage regime: from months to years
Geriatric
  • Disease: Alcoholism
  • Before or After Meal: After Meal
  • Single Maximum Dose: 500 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: 2 weeks
  • Special Instructions: Later decrease dose up to 250 mg once daily, dosage regime: from months to years


Zanofiram Side Effects

Based on research, the following side effects have been observed when Zanofiram is used -

Severe

Moderate

  • Weakness
  • Restlessness
  • Fainting
  • Visual Disturbance

Mild

Zanofiram Related Warnings

  • Is the use of Zanofiram safe for pregnant women?


    Zanofiram may cause moderate side effects during pregnancy. If you feel its harmful effects, then stop taking this drug immediately, and do not take Zanofiram again without your doctor's advice.

    Moderate
  • Is the use of Zanofiram safe during breastfeeding?


    Taking Zanofiram may lead to serious side effects if you are breastfeeding. Zanofiram should not be taken by breastfeeding women unless prescribed by the doctor.

    Severe
  • What is the effect of Zanofiram on the Kidneys?


    Zanofiram rarely harms the kidneys.

    Mild
  • What is the effect of Zanofiram on the Liver?


    Zanofiram is rarely harmful for the liver.

    Mild
  • What is the effect of Zanofiram on the Heart?


    Zanofiram may have mild side effects on the heart. Most people will never see any effect on the heart.

    Mild


Severe Interaction of Zanofiram with Other Drugs

Zanofiram should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate

Mild



Zanofiram Contraindications

If you are suffering from any of the following diseases, you should not take Zanofiram unless your doctor advises you to do so -



Frequently asked Questions about Zanofiram

  • Is this Zanofiram habit forming or addictive?


    No, there is no any evidence that Zanofiram is addictive.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should not drive or operate heavy machinery after taking Zanofiram as you may feel sleepy.

    Dangerous
  • Is it safe?


    Zanofiram should be used only after doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Zanofiram is not used to treat mental disorders.

    No

Zanofiram Interactions with Food and Alcohol

  • Interaction between Food and Zanofiram


    It is safe to take Zanofiram with food.

    Safe
  • Interaction between Alcohol and Zanofiram


    Consumption of alcohol and Zanofiram together may have severe effects on your health.

    Severe


Frequently asked Questions about Zanofiram

Question almost 5 years ago

Is Zanofiram safe to use?

Dr. Saikat Mukherjee MBBS , General Physician

Yes, Zanofiram is safe to use, if taken in a prescribed amount for a specified time as advised by the doctor. However, some known side effects are observed at the therapeutic dose level such as drowsiness, tiredness, skin rash, and acne. Do not hesitate to inform your doctor if you are facing any of the above.

Question about 5 years ago

How long can I safely take Zanofiram?

Dr. Saikat Mukherjee MBBS , General Physician

Take Zanofiram as advised by your doctor. Do not take it longer than prescribed.

Question almost 5 years ago

Does Zanofiram cause weight gain?

Dr Anjum Mujawar MBBS, MBBS , Emergency Medicine

No, Zanofiram does not cause weight gain in patients who are taking it. However, if you are experiencing any unusual weight gain after taking this drug then inform your doctor immediately without any further delay.

Question about 5 years ago

How to take Zanofiram?

Dr. Piyush Malav MBBS, MS , General Surgery

Zanofiram comes in form of tablet and it should be taken by mouth once daily or as advised by your doctor. Precautions must be taken in patients with diabetes, epilepsy, respiratory disorders, cerebral damage, hypothyroidism, and in people with impaired liver or kidney function. Do not drive any vehicle or operate machinery after taking this medicine as it can cause drowsiness or sedation. Also avoid sauces, vinegars, all foods, beverages and medicines such as cough syrup containing alcohol while taking disulfiram to experience best results with minimal side effects. 
 

Question about 5 years ago

What is Zanofiram?

Dr. Surender Kumar MBBS , General Physician

Zanofiram is a brand name of disulfiram. It is a prescription drug that belongs to the class of drugs known as alcohol deterrents (detoxifying agents). It is used for the treatment and management of chronic alcoholism.



See all substitutes for Zanofiram


This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 394

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Antabuse® (disulfiram)



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