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  1. myUpchar
  2. Medicine
  3. Isolazine

Isolazine

  • Manufactured by: Lupin Ltd
  • Contains / Salt: Isosorbide Dinitrate (20 mg) + Hydralazine (37.5 mg)
  • Storage: Store at room temperature

Isolazine

Prescription Required

449 people have bought this recently


  • Manufactured by: Lupin Ltd
  • Contains / Salt: Isosorbide Dinitrate (20 mg) + Hydralazine (37.5 mg)
  • Storage: Store at room temperature

Seller: Apollo Pharmacy Limited

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  • In stock alternatives of Isolazine
    (based on Isosorbide Dinitrate (20 mg) + Hydralazine (37.5 mg))
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Isolazine Information

Isolazine, a prescription drug, is manufactured in various forms such as Tablet. The alternative uses of Isolazine have also been explained below.

The optimal dosage of Isolazine is largely dependent on the individual's body weight, medical history, gender and age. Individual symptoms and route of administration also determines the right dosage. Refer to the dosage section for a detailed discussion.

Isolazine also has some side effects, the most common being Peripheral Edema, Jaw Pain, Chest Discomfort. Besides the aforementioned side effects, there are other adverse effects of Isolazine as well, which are listed below. Normally, these side effects of Isolazine are not long lasting and go away when the treatment is finished. However, if these continue for a longer time, consult your doctor right away.

It is also important to note that Isolazine has a Moderate effect for pregnant women and Safe effect on lactating mothers. It is important to know if Isolazine has any effect on the kidney, liver and heart. Information on such adverse effects, if any, has been given in the Isolazine related warnings section.

Isolazine can cause adverse effects in certain medical conditions. It is strongly recommended to avoid Isolazine in conditions like Low Blood Pressure (Hypotension), Anemia, Angina. Other conditions have been mentioned below in the Isolazine contraindications section.

Drug interactions for Isolazine have been reported in the medical literature. See below for a complete list.

Along with the above-mentioned precautions, remember that taking Isolazine is considered not safe while driving, and is not addictive.

  1. Isolazine Benefits & Uses
  2. Isolazine Dosage & How to Take
  3. Isolazine Side Effects
  4. Isolazine Related Warnings
  5. Severe Interaction of Isolazine with Other Drugs
  6. Isolazine Contraindications
  7. Frequently asked Questions about Isolazine
  8. Isolazine Interactions with Food and Alcohol

Isolazine Benefits & Uses

Isolazine is used to treat the following -

Other Benefits

  • Heart Failure

Isolazine Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Heart Failure
  • Before or After Meal: Either
  • Single Maximum Dose: 1 Tablet
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 3 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: strength 37.5 mg hydralazine and isosorbide dinitrate 20 mg
Geriatric
  • Disease: Heart Failure
  • Before or After Meal: Either
  • Single Maximum Dose: 1 Tablet
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 3 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: strength 37.5 mg hydralazine and isosorbide dinitrate 20 mg

Isolazine Side Effects

Based on research, the following side effects have been observed when Isolazine is used -

Moderate

  • Decreased blood pressure
  • Palpitations (fluttering in chest)
  • Angina Pectoris

Mild

  • Headache
  • Dizziness
  • Nausea or vomiting
  • Dry Mouth
  • Loss of appetite
  • Diarrhoea

Common

  • Peripheral Edema
  • Jaw Pain
  • Chest Discomfort
  • Shortness of Breath
  • Chest Pain

Isolazine Related Warnings

  • Is the use of Isolazine safe for pregnant women?


    Isolazine may have some side effects during pregnancy. Pregnant women should discontinue the use of Isolazine, and talk to their doctor, if they notice any discomfort.

  • Is the use of Isolazine safe during breastfeeding?


    Breastfeeding women can safely use Isolazine.

  • What is the effect of Isolazine on the Kidneys?


    Isolazine has very mild side effects on the kidneys.

  • What is the effect of Isolazine on the Liver?


    Isolazine is rarely harmful for the liver.

  • What is the effect of Isolazine on the Heart?


    Side effects of Isolazine rarely affect the heart.


Severe Interaction of Isolazine with Other Drugs

Isolazine should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Sildenafil
  • Bold Care 50 Tablet
  • Manforce 100 Mg Tablet
  • Penegra 50 Tablet
  • Penegra Xpress 50 Tablet
Chlorpheniramine,Dextromethorphan,Paracetamol,Phenylephrine

    Moderate

    Paracetamol,Codeine
      Alprazolam
      • Alprax Z 0.25/3 Tablet
      • Stresnil 0.5 Tablet
      • Alprax 0.5 Tablet
      • Alprax 0.25 Tablet SR
      Codeine
      • Codistar DX Cough Syrup 60ml
      • Codistar DX Cough Syrup 100ml
      • Ascoril C Syrup
      • Codistar 4 Mg/10 Mg Syrup 100ml
      Lisinopril
      • Amlopres L Tablet
      • Listril Plus Tablet
      • Lipril 2.5 Tablet (15)
      • Lipril 5 Tablet (15)
      Sildenafil
      • Bold Care 50 Tablet
      • Manforce 100 Mg Tablet
      • Penegra 50 Tablet
      • Penegra Xpress 50 Tablet
      Ketoprofen
      • Lupiflex 4 Tablet
      • Lupiflex 8 Tablet
      • Fastum Gel
      • Deep Senz Ointment
      Ibuprofen
      • Brufen 400 Tablet
      • Brufen 600 Tablet
      • Brufen 200 Tablet
      • Imol Plus Tablet
      Isoniazid
      • Akurit 4 Tablet
      • Solonex DT Tablet
      • Forecox Tablet
      • Solonex Tablet

      Isolazine Contraindications

      If you are suffering from any of the following diseases, you should not take Isolazine unless your doctor advises you to do so -

      • Low Blood Pressure
      • Anemia
      • Glaucoma
      • Angina
      • Heart Failure
      • Kidney Disease

      Frequently asked Questions about Isolazine

      • Is this Isolazine habit forming or addictive?


        Forming a habit of Isolazine has not been reported.

      Isolazine Interactions with Food and Alcohol

      • Interaction between Food and Isolazine


        Taking Isolazine with food does not cause any problems.

      • Interaction between Alcohol and Isolazine


        It is difficult to say anything about the effect of Isolazine and alcohol. No research has been done on this yet.


      Frequently asked Questions about Isolazine

      Question almost 3 years ago

      Does Isolazine lower blood pressure (hypotension)?

      Dr. Suhas Bhargav MBBS , General Physician

      Yes, Isolazine may lower blood pressure (hypotension) in some cases. It is an uncommon side effect of this drug. However, if you are experiencing lightheadedness or dizziness which is a symptom of low blood pressure (hypotension) then you are advised to lay down immediately till it subsides if it worsens then inform your doctor without further delay.

      Question about 3 years ago

      Can I take Isolazine without consulting a doctor?

      Dr. Vedprakash Verma MBBS , General Physician

      No, Isolazine is a prescription drug, so do not take it without consulting a doctor. It can be harmful to the patient to take this medicine without a doctor's recommendation because it can cause very unpleasant side effects. Hence, the patient should seek doctors advice before taking this medication by himself or herself.

      Question over 3 years ago

      How does Isolazine work?

      Dr. Roshni Poonja MBBS , General Physician, Internal Medicine

      Isolazine contains isosorbide dinitrate which is a vasodilator. It works by causing relaxation of vascular smooth muscle and dilation of the blood vessels (vasodilation) which promotes increase in oxygen and blood supply to the heart this also reduces the workload of the heart (reduces preload and afterload).

      Question over 3 years ago

      What is Isolazine?

      Dr. Chinmaya Bal MBBS , General Physician

      Isolazine is a brand name of isosorbide dinitrate and it is available in the form of a tablet and capsule. It belongs to the class of drug known as nitrate vasodilators. It is a prescription drug which is used in the prevention of angina pectoris (chest pain) in patients with coronary artery disease (CAD).

      Question almost 3 years ago

      Can Isolazine cause weight gain?

      Dr. Saikat Mukherjee MBBS , General Physician

      No, Isolazine does not cause weight gain. It has not been reported by the patients who are taking this drug. If you are experiencing any unusual weight gain after taking this drug, then it might be due to some other reason and you are advised to discuss it with your doctor.


      See all substitutes for Isolazine

      • Isordil 10 Mg Tablet - ₹5.74
      • Sorbitrate 5 Tablet (50) - ₹39.9
      • Isordil 5 Mg Tablet - ₹8.0
      • Sorbitrate 10 Tablet (50) - ₹40.88
      • Cardicap 10 Mg Tablet - ₹11.23
      • Hydralaze Tablet - ₹95.23
      • Cordil 5 Mg Tablet - ₹105.0
      • Sorbidine Tablet - ₹163.2
      • Sorbitrate 10 Tablet (30) - ₹26.6
      • Isosorbide Dinitrate Tablet - ₹46.0
      • Hydralazine Tablet - ₹525.0

      This medicine data has been created by -

      Vikas Chauhan

      B.Pharma, Pharmacy
      3 Years of Experience


      References

      US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Isordil® Titradose™ (isosorbide dinitrate)

      KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 543-544

      April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 653-654

      US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Hydralazine hydrochloride

      KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 566-567

      April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 651-653

      • 449 people have bought this recently
      • ₹149.9 ₹157.8 4% off
      • 15 Tablet in 1 Strip
      • Buy Now
      • In stock alternatives of Isolazine
        (based on Isosorbide Dinitrate (20 mg) + Hydralazine (37.5 mg))
      • Isordil 10 Mg Tablet ₹5.74 ₹7.0 18.0%
      • Sorbitrate 5 Tablet (50) ₹39.9 ₹42.0 5.0%
      • Isordil 5 Mg Tablet ₹8.0 ₹8.4 4.76%
      • Sorbitrate 10 Tablet (50) ₹40.88
      • Cardicap 10 Mg Tablet ₹11.23
      • You may also like
      • Lanoxin Tablet ₹12.7 ₹13.35 4.87%
      • Nebicip 5 Tablet ₹107.5 ₹113.13 4.98%
      • Hyponat O 15 Tablet ₹533.9 ₹561.95 4.99%
      • Enapril 5 Tablet ₹51.1 ₹53.76 4.95%
      • Cetanil T 20 Tablet ₹155.9 ₹164.1 5.0%
      ₹149.9 ₹157.8 4% off
      15 Tablet in 1 Strip

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