Paraglan

Yes, Paraglan can be taken safely with a less sedative antihistaminic drug like cetirizine and loratadine etc. No harmful effects are reported. However, another group of antihistamine drug which causes drowsiness and sleepiness like chlorpheniramine, diphenhydramine etc. should not be taken together unless and until recommended by your doctor.

Paraglan is not recommended for back pain. However, It can be taken along with a painkiller for the treatment of back pain. 

An overdose occurs when more than the required amount (toxic levels) of [medicine] is taken. Initial symptoms of Paraglan overdose includes loss of appetite, drowsiness, seizures, abdominal pain, nausea, and vomiting. Later progressive symptoms may include pain in your upper stomach, dark colored urine, yellowing of your skin or the white patches in your eyes, liver damage and in rare cases, it can also lead to coma. So, by any chance, if you have accidentally taken more than the required dose of Paraglan inform your doctor immediately.

As we know Paraglan is most widely used 'over-the-counter' analgesic/antipyretic medicine. However, paracetamol overdose can cause serious adverse effects on the liver, it may be fatal. But fortunately, there is an antidote, N-acetylcysteine (NAC) given within 8 hours of Paraglan ingestion which usually can prevent all serious side effects of Paraglan poisoning. However, do not take NAC without consulting a doctor as your doctor will tell you the right way and methods to help you relieve from this drug poisoning.

You should take the minimum effective dose of Paraglan that reduces body pain and fever. It should be used for the shortest time period till you get relief. Take it as per doctor's advice do not exceed dosage. Ideally, 1 or 2 tablets (500 mg) every four to six hours can be safely taken, do not take more than four doses in 24 hours. Please note paracetamol 500 mg tablet should not be given to children below 10 years until and unless prescribed by a child specialist.