Rational

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  • Contains / Salt: Ofloxacin (200 mg)
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Rational Information

Rational is a prescription drug, available for use as Tablet. Primarily, it is used for the treatment of Urinary Tract Infection, Ear Infection, Bacterial Infections. Other than this, Rational has some other therapeutic uses, which have been discussed ahead.

Medical history of the patient along with age and gender determines the dosage of Rational. The condition it has been prescribed for, and the route of administration also determine the right dosage. This information has been provided in detail in the dosage section.

Besides the aforementioned side effects, there are other adverse effects of Rational as well, which are listed below. Such side effects of Rational normally do not last long and go away once the treatment is completed. Please speak with your doctor if these side effects worsen or persist for a longer duration.

Furthermore, you should know that effect of Rational is Moderate for pregnant women and Moderate for women who are breastfeeding. Warnings related to Rational's effects on the liver, heart and kidney, if any, have been listed below.

Rational can cause adverse effects in certain medical conditions. It is strongly recommended to avoid Rational in conditions like Atrial Fibrillation, Heart Failure, Myasthenia Gravis (MG). Some other conditions that can be affected by Rational are listed in the contraindications section below.

Drug interactions for Rational have been reported in the medical literature. See below for a complete list.

You should also be aware that Rational is not safe while driving, and is not addiction.



Rational Benefits & Uses

Rational is used to treat the following -

Other Benefits

Rational Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Skin Infections
  • Before or After Meal: After Meal
  • Single Maximum Dose: 400 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: 10 days
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Skin Infections
  • Before or After Meal: After Meal
  • Single Maximum Dose: 400 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: 10 days
  • Special Instructions: As prescribed by the doctor
13 - 18 years (Adolescent)
  • Disease: Typhoid Fever
  • Before or After Meal: After Meal
  • Single Maximum Dose: 300 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor


Rational Side Effects

Based on research, the following side effects have been observed when Rational is used -

Severe

  • Allergic reaction
  • Visual impairment
  • Steven-johnsons syndrome
  • Bronchospasm
  • Hearing Loss

Moderate

Mild

Rational Related Warnings

  • Is the use of Rational safe for pregnant women?


    Rational may cause moderate side effects during pregnancy. If you feel its harmful effects, then stop taking this drug immediately, and do not take Rational again without your doctor's advice.

    Moderate
  • Is the use of Rational safe during breastfeeding?


    Breastfeeding women may feel side effects of Rational. If you see any side effects, stop taking Rational immediately and talk to your doctor. Take Rational again, only after your doctor's advice.

    Moderate
  • What is the effect of Rational on the Kidneys?


    Rational may have mild side effects on the kidneys.

    Mild
  • What is the effect of Rational on the Liver?


    Rational may have mild side effects on the liver. Most people will never see any effect on the liver.

    Mild
  • What is the effect of Rational on the Heart?


    Rational is rarely harmful for the heart.

    Mild


Severe Interaction of Rational with Other Drugs

Rational should not be taken with following medicines due to severe side effects it may cause to patients -

Life Threatening

Severe

Moderate

Mild



Rational Contraindications

If you are suffering from any of the following diseases, you should not take Rational unless your doctor advises you to do so -



Frequently asked Questions about Rational

  • Is this Rational habit forming or addictive?


    Rational does not cause addiction.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    After taking Rational you may feel sleepy. So it is not advised to perform these activities.

    Dangerous
  • Is it safe?


    Rational is safe but it is important to consult a doctor before taking it.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, the use of Rational in mental disorders is not effective.

    No

Rational Interactions with Food and Alcohol

  • Interaction between Food and Rational


    When consumed with certain foods, Rational may take longer to have an effect. Contact your doctor about this.

    Mild
  • Interaction between Alcohol and Rational


    Consuming Rational with alcohol can have many serious effects on your body.

    Severe


Frequently asked Questions about Rational

Question about 5 years ago

How long can I safely take Rational?

Dr. Madhur Anand MBBS, MS , General Surgery

Take Rational as directed by your doctor. Do not take this medicine longer than prescribed.

Question almost 5 years ago

Is Rational safe?

Dr. Surender Kumar MBBS , General Physician

Yes, Rational is safe to use, if taken in the prescribed amount and duration as advised by the doctor. However, certain side effects have been associated with this drug such as stomach pain, nausea, diarrhea, headache, difficulty in breathing, and constipation.

Question over 4 years ago

Can I take Rational with metformin?

Take Rational if your doctor has prescribed it to you. However, keep a close check on blood sugar levels as metformin is known to cause hypoglycemia( sudden dip in blood sugar levels). In case you are experiencing severe hypoglycemia, please inform your doctor immediately.

Question over 4 years ago

can I take Rational for UTI infection?

Dr. Faisal Mukhtar MBBS, PG Dip, DNB , Ophthalmology

Yes, you can take Rational for UTI infection. It is the first-line drug for treating UTI infection. It is active against the bacteria which causes UTI infection. However, you must follow the entire course of this medicine and do not discontinue medication without consulting your doctor.

Question almost 5 years ago

Can I take Rational with azithromycin?

Dr. Gaurav MBBS , General Physician

It is recommended to avoid taking Rational with azithromycin because it can cause heart-related problems. However, if your doctor has prescribed it to you take it as per his/her advice. In case you are experiencing breathing difficulties, palpitations and pain in the chest please inform your doctor immediately.



See all substitutes for Rational


This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1400

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 713

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Floxin® (ofloxacin)

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Ocuflox® (ofloxacin)

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