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What is Male Hypogonadism?

Male hypogonadism is a condition characterised by a deficiency in the testosterone levels (hormone playing main role in the growth and development of males during puberty), as the body is not able to produce it in sufficient quantities. This condition can have a great impact on the quality of life of the affected. Besides being a sex hormone, testosterone is considered critical for sexual, cognitive, and body functions (which includes the functioning of the brain and metabolic and vascular systems) and development.

Hypogonadism is of two types, i.e., primary (in the testicles) and secondary (in the hypothalamus or pituitary gland).

What are the main signs and symptoms?

The common signs and symptoms of hypogonadism include

  • Anaemia
  • Muscle wasting
  • Reduced bone mass or bone mineral density or osteoporosis
  • Abdominal fat
  • Hot flushes
  • Decreased body hair
  • Delayed epiphyseal closure
  • Gynaecomastia
  • Sexual dysfunction, including
    • Erectile dysfunction
    • Reduced energy, stamina, libido, penile sensation, or sperm count
    • Difficulty attaining orgasm
    • Small testes
    • Depressed mood or increased irritability
    • Concentration difficulty
    • Changes in cholesterol levels

What are the main causes?

The main causes of primary hypogonadism are

  • Old age
  • Klinefelter's syndrome
  • Mumps orchitis
  • Haemochromatosis
  • Injured or undescended testicles
  • Cancer treatment including chemotherapy or radiation therapy

The main causes of secondary hypogonadism are

  • Obesity
  • Disorders of the pituitary gland
  • Stress-induced hypercortisolism
  • HIV/AIDS
  • Kallmann syndrome
  • Diseases which includes tuberculosis, sarcodiosis, histiocytosis
  • Medications, such as opiate pain drugs and hormones

How is it diagnosed and treated?

The diagnosis is made by the physician mainly based on the symptoms, and the following tests are advised:

  • Hormone testing
  • Serum testosterone or free testosterone
  • Serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) for secondary hypogonadism
  • Semen analysis
  • Pituitary imaging
  • Testicular biopsy
  • Genetic studies

The first line of treatment is testosterone replacement therapy, which should provide 300-800 ng/dL of testosterone. It can be in the form of:

  • A transdermal patch that delivers testosterone over a 24-hour period continuously.
  • Buccal testosterone tablets, which are used as pulsatile release of testosterone.
  • An implantable pellet, which is surgically implanted intended for slow release.
  • Topical gel, which is used for longer-lasting elevations in serum testosterone.
  • Intramuscular injections are used for prolonged absorption, which are suspended in oil.
  • Oral testosterone tablets, currently not available in India.

 

  1. Medicines for Male Hypogonadism

Medicines for Male Hypogonadism

Medicines listed below are available for Male Hypogonadism. Please note that you should not take any medicines without doctor consultation. Taking any medicine without doctor's consultation can cause serious problems.

Medicine NamePack SizePrice (Rs.)
Coriosurge XpCoriosurge Xp 10000 Iu Injection838.0
Eema HpEema Hp 10000 Iu Injection900.0
Fertigyn HpFertigyn Hp 10000 Iu Injection890.0
Hucog Hp InjectionHucog Hp 10000 Iu Injection978.0
Materna Hcg HpMaterna Hcg Hp 5000 Iu Injection527.0
Ovutrig HpOvutrig Hp 10000 Iu Injection827.0
PubergenPubergen 10000 Iu Injection696.0
Zyhcg HpZyhcg Hp 10 K Injection890.0
ChoragonChoragon 5000 Iu Injection462.0
ChoriodayChorioday 5000 Iu Injection475.0
ChoriolifeChoriolife 2000 Iu Injection276.0
ChoriotecChoriotec 10000 Iu Injection856.0
CorionCorion 10000 Iu Injection630.0
Corion CCorion C 5000 Iu Injection495.0
Coriosurge HpCoriosurge Hp 5000 Iu Injection283.0
Eutrig HpEutrig Hp 10000 Iu Injection400.0
FertigynFertigyn 10000 Iu Injection890.0
HcgHcg 2000 Iu Injection269.0
Hcg SpHcg Sp 10000 Iu Injection750.0
HtropHtrop 10000 Iu Injection806.0
KoragonKoragon 5000 Iu Injection405.0
Koragon HpKoragon Hp 5000 Iu Injection573.0
Lutigen GoldLutigen Gold 2000 Iu Injection187.0
My HcgMy Hcg 2000 Iu Injection360.0
Neo HcgNeo Hcg 10000 Iu Injection516.0
OrigenOrigen 2000 Iu Injection277.0
OvidrelOvidrel 250 Mcg Injection1428.0
Ovifer HpOvifer Hp Injection450.0
Ovipure HpOvipure Hp 10000 Iu Injection930.0
OvitrellaOvitrella 250 Mcg Injection1500.0
Ovulate COvulate C 10000 Iu Injection437.0
Ovumax HpOvumax Hp 10000 Iu Injection790.0
Ovunal HpOvunal Hp 10000 Iu Injection880.0
OvutrigOvutrig 2000 Iu Injection340.0
PregnylPregnyl 1500 Iu Injection230.0
ProfasiProfasi 2000 Iu Injection327.0
ProferticProfertic 10000 Iu Injection970.0
ProficentProficent 2000 Iu Injection309.0
ProvigilProvigil 5000 Iu Injection506.0
Pubergen AquaPubergen Aqua 5000 Iu Injection580.0
Pubergen HpPubergen Hp 2000 Iu Injection252.0
Pubergen JoPubergen Jo 7500 Iu Injection603.0
Pubergen NanoPubergen Nano 500 Iu Injection216.0
SifasiSifasi 5000 Iu Injection385.0
Sifasi HpSifasi Hp 10000 Iu Injection1088.0
StimogonStimogon 10000 Iu Injection500.0
ZyhcgZyhcg 2000 Iu Injection307.0
AnserAnser 5000 Iu Injection419.0
DevironDeviron 2000 Iu Injection200.0
Life 250Life 250 250 Mcg Prefilled Syringe1400.0
MaternaMaterna Depot 3.75 Mg Injection4000.0
Materna HcgMaterna Hcg 5000 Iu Injection551.0
OvidacOvidac 2000 Iu Injection337.0
OvigynOvigyn 5000 Iu Injection447.0
Provigil HpProvigil Hp 5000 Iu Injection225.0
Sven HcgSven Hcg 5000 Iu Injection180.0
Trigova HpTrigova Hp 10000 Iu Injection880.0
CernosCernos 1% W/W Gel70.0
Diva HmgDiva Hmg 150 I.U Injection955.0
Gmh HpGmh Hp 150 Iu Injection1485.0
HumogHumog 150 Iu Injection Injection 150 Iu1102.0
Materna HmgMaterna Hmg 150 I.U Injection1187.5
MenotasMenotas 150 I.U Injection942.86
My HmgMy Hmg 150 Iu Injection1523.81
ZyhmgZyhmg 150 I.U Injection986.0
Zyhmg HpZyhmg Hp 150 I.U Injection1514.28
Eema HmgEema Hmg 150 Iu Injection1600.0
EugonEugon Hp 150 Iu Injection1333.32
GmhGmh 75 Iu Injection985.0
GynogenGynogen 150 Iu Injection1400.0
Hmg SpHmg Sp 75 Iu Injection850.0
MagnacentMagnacent 150 I.U Injection1589.52
MenonysMenonys 150 Iu Injection537.5
Ovugraf HpOvugraf Hp 150 Iu Injection1600.0
PersinalPersinal 150 Iu Injection1484.9
Persinal HpPersinal Hp 150 Iu Injection1935.9
ReprogonReprogon 75 Iu Injection400.0
SitrodinSitrodin 150 Iu Injection1428.57
MenodacMenodac 150 I.U Injection1080.0
Diva FshDiva Fsh 150 Iu Injection1510.0
Eema R FshEema R Fsh 300 Iu Injection7500.0
FoligemFoligem 150 Iu Injection1800.0
FolisurgeFolisurge 1200 Iu Injection21904.8
Gonal FGonal F 1050 Iu Injection27154.5
Newmon RNewmon R 150 Iu Injection2977.1
Ovitrop ROvitrop R 300 Iu Injection7000.0
RecagonRecagon 100 Iu Injection3214.0
Stimufol PStimufol P 150 Iu Injection642.86
BravelleBravelle 100 Iu Injection1442.0
EndogenEndogen 150 Iu Injection1153.0
FoligrafFoligraf 150 Iu Injection3675.0
FostirelFostirel 1200 Iu Injection17000.0
FshspFshsp 150 Iu Injection850.0
FtropFtrop 150 Mg Injection1500.0
GonarecGonarec 75 Iu Injection1800.0
GrafyrecGrafyrec 1200 Iu Injection24761.9
HumegonHumegon 75 Iu Injection595.0
Luveris (Merck)Luveris 75 Iu Injection2137.0
Metrodin HpMetrodin Hp 75 Iu Injection1249.7
NeogentinNeogentin 150 Iu Injection1130.0
Zy Fsh HpZy Fsh Hp 150 I.U Injection1750.0
FollitecFollitec 75 Mg Injection750.0
GrafovaGrafova 150 Mg Injection1050.0
UtrovaUtrova 150 Mg Injection1450.0
Eema FshEema Fsh 150 Iu Injection1850.0
Endogen HpEndogen Hp 150 Iu Injection1437.5
EuvifolEuvifol Hp 150 Iu Injection750.0
FoliculinFoliculin 150 Iu Injection1659.0
Foliculin HpFoliculin Hp 150 Iu Injection1785.0
FoligestFoligest 150 Iu Injection995.0
FolliovaFolliova 150 Iu Injection587.5
MetrodinMetrodin 75 Iu Injection1250.65
My FshMy Fsh 150 Iu Injection1809.52
Proferti FProferti F 150 Iu Injection1300.0
Eventin HpEventin Hp 75 Iu Injection387.5
FostineFostine 150 Iu Injection1300.0
OvitropOvitrop 150 I.U Injection1850.0
Ovitrop HpOvitrop Hp 150 I.U Injection1750.0
FsxFsx 25 Mg Capsule62.7
GroferGrofer 25 Mg Capsule95.0
My DheaMy Dhea 25 Mg Capsule116.0
OvafloOvaflo 25 Mg Capsule63.0
OvaresOvares 25 Mg Capsule159.0
OviservOviserv 25 Mg Capsule142.0
OvusparkOvuspark 25 Mg Capsule90.47
Safegest DSafegest D 75 Mg Tablet94.28
StimugestStimugest 25 Mg Capsule183.0
XtrophiXtrophi 0.25% Tablet99.0
Andreva SrAndreva Sr Tablet228.0
DaliaDalia 25 Mg Capsule110.0
DepidraDepidra Capsule118.1
Eema DEema D 25 Mg Capsule108.0
Fulfil SrFulfil Sr Tablet 75 Mg350.0
FulfilFulfil 25 Mg Tablet115.0
Micronised Ovigyn DMicronised Ovigyn D 75 Mg Tablet Sr328.2
OvafemOvafem 75 Mg Capsule360.0
OvicardOvicard Sr 75 Mg Tablet350.0
Ovigyn DOvigyn D 25 Mg Capsule125.85
OvisteroneOvisterone 25 Mg Capsule130.0
Ovisterone PcoOvisterone Pco Tablet275.0
PrastovaPrastova 75 Mg Tablet Sr308.0
RichovaRichova Sr 75 Mg Tablet250.0
Brainstar OdBrainstar Od 2.5 Mg Tablet104.0
BrainstarBrainstar 0.8 Mg Tablet61.9
CyclosetCycloset Syrup180.45
DbroDbro 0.8 Mg Tablet69.9
DiacriptinDiacriptin 0.8 Mg Tablet70.0
GlucomindGlucomind 0.8 Mg Tablet66.0
ProctinalProctinal 2.5 Mg Tablet151.65
Semi BromSemi Brom 1.25 Mg Tablet87.78
SicriptinSicriptin 1.25 Mg Tablet85.4
BromBrom 1.25 Mg Tablet157.49
BromogenBromogen 1.25 Mg Tablet71.6
BromorexBromorex 1.25 Mg Tablet132.87
Brom (Hic)Brom Syrup41.9
CriptalCriptal 1.25 Mg Tablet65.0
EncriptEncript 2.5 Mg Tablet138.87
SicreptinSicreptin 1.25 Mg Tablet78.03
Sicriptin UspSicriptin Usp 2.5 Mg Tablet143.95
AndriolAndriol 40 Mg Capsule119.33
AndrogelAndrogel 50 Mg Gel2700.0
AndrosureAndrosure 1% Gel464.82
AquavironAquaviron 25 Mg Injection110.0
MenolonMenolon Injection189.0
Sustanon (Organon)Sustanon 100 Mg Injection131.0
TestofilTestofil Depot 1000 Mg Injection612.0
TestokiTestoki 100 Mg Injection78.6
Testoviron InjectionTestoviron Depot 100 Mg Injection130.0
AndrofilAndrofil 40 Mg Capsule167.38
ArnoldArnold 250 Mg Injection60.0
NuvirNuvir 40 Mg Capsule337.0
TestoretardTestoretard 100 Mg Injection99.92
Testosterone UndecanoateTestosterone Undecanoate 40 Mg Capsule450.42
SustainSustain 40 Mg Injection82.86
TestosprayTestospray 12.5 Mg Spray1723.38
Diva Hmg HpDiva Hmg Hp 150 Iu Injection1234.58
EventinEventin 150 Iu Injection500.0
LuverisLuveris 75 Iu Injection2054.81
MenovulMenovul 150 Iu Injection874.28
Ovulate MOvulate M 150 Iu Injection875.0
MenogonMenogon 75 Iu/75 Iu Injection937.4
MestilonMestilon Tablet163.5
ProvironumProvironum 25 Mg Tablet271.0
RestoreRestore 25 Mg Tablet192.48
ViropaceViropace 25 Mg Tablet243.75
Coedhea PlusCoedhea Plus 75 Mg/500 Mg Capsule254.7
Diacriptin MDiacriptin M 0.8 Mg/500 Mg Tablet0.0
EvaserveEvaserve 4.5 Mg/75 Mg Tablet450.0
OvstoreOvstore 25 Mg/1.5 Mg Capsule154.0
Humog HpHumog Hp 150 Iu/150 Iu Injection1680.0
MenopurMenopur Injection7352.0
Ovanac DsrOvanac Dsr 75 Mg/3 Mg Tablet285.0

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