Mantle Cell Lymphoma

Dr. Ayush PandeyMBBS,PG Diploma

December 10, 2018

March 06, 2020

Mantle Cell Lymphoma
Mantle Cell Lymphoma

What is Mantle Cell Lymphoma?

Mantle Cell Lymphoma (MCL) is a type of non-Hodgkin lymphoma, which is aggressive and rare. In MCL, the lymphoma originates from the mantle zone or the corona of the lymph node. Mantle cell lymphoma generally involves the digestive tract and the bone marrow.

What are its main signs and symptoms?

MCL has symptoms similar to that of other lymphomas. The early symptoms of MCL can be easily overlooked or taken as common health issues. Some of the early symptoms of MCL are:

Some of the advanced stage symptoms of MCL are:

What are its main causes?

MCL has several causes and yet the exact reason which leads to MCL is unknown. More than 90% of the patients with MCL are found to have an overproduction of the protein cyclin D1. Also found in excess are proteins like lactate dehydrogenase and beta 2 microglobulin.

How is it diagnosed and treated?

If the patient’s symptoms indicate a possible lymph tumour or cancer, then the doctor or pathologist will suggest a biopsy to examine and determine the kind of cell present in the cancerous growth.

On detection of lymphoma cells, further tests are carried out which include X-rays of the chest, blood tests, along with, imaging scans like computed tomography (CT) or magnetic resonance imaging (MRI) to determine the growth and identify the affected areas.

The treatment of MCL is carried out based upon the stage of cancer.

The most common treatment in the early stages are medicinal/ pharmacologic; however, in the later stages, chemotherapy and radiation therapy are introduced. Drugs such as rituximab, which target the cancerous B-cells are also found to be useful in advanced stages. In special cases of severe immune weakness, doctors carry out a bone marrow or stem cell transplant, which helps in building new and healthy immune cells.


  1. Lymphoma Research Foundation. [Internet]. New York. About Lymphoma.
  2. National Center for Advancing and Translational Sciences. [Internet]. U.S. Department of Health and Human Services; Mantle cell lymphoma.
  3. Michael Schieber. et al. Current overview and treatment of mantle cell lymphoma. Version 1. F1000Res. 2018; 7: F1000 Faculty Rev-1136. PMID: 30109020.
  4. Lynch DT, Acharya U. Cancer. Cancer, Mantle Cell Lymphoma. [Updated 2019 Feb 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.
  5. US Food and Drug Administration (FDA) [internet]; FDA approves new treatment for adults with mantle cell lymphoma.

Medicines for Mantle Cell Lymphoma

Medicines listed below are available for Mantle Cell Lymphoma. Please note that you should not take any medicines without doctor consultation. Taking any medicine without doctor's consultation can cause serious problems.

Medicine Name











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