Estradiol

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Estradiol Information

Estradiol is a prescription medicine. It is typically used for the treatment of Post Menopausal Osteoporosis, Urethritis, Vaginal atrophy. Secondary and off-label uses of Estradiol have also been mentioned below.

The correct dosage of Estradiol depends on the patient's age, gender, and medical history. Dosage also depends on the route of administration and your chief complaint for which the drug is prescribed. This information has been provided in detail in the dosage section.

The most common side effects of Estradiol are Weight gain, Metrorrhagia, Edema. Some other side effects of Estradiol have been listed ahead. Such side effects of Estradiol normally do not last long and go away once the treatment is completed. If, however, they worsen or do not go away, please speak with your physician.

It is also important to note that Estradiol has a Severe effect for pregnant women and Severe effect on lactating mothers. In addition, Estradiol's effects on the liver, heart and kidney are discussed below in the Estradiol related warnings section.

Individuals suffering from medical conditions like High Blood Pressure, Blood Clotting Disorders, Thrombophlebitis must refrain from the use of Estradiol since this can cause severe adverse effects. Some other conditions that can be affected by Estradiol are listed in the contraindications section below.

Drug reaction of Estradiol with other medicines has been reported. See below for a complete list.

In addition to the above precautions for Estradiol, it is important to know that it is safe while driving, and is habit-forming.

  1. Estradiol Benefits & Uses
  2. Estradiol Dosage & How to Take
  3. Estradiol Side Effects
  4. Estradiol Related Warnings
  5. Severe Interaction of Estradiol with Other Drugs
  6. Estradiol Contraindications
  7. Frequently asked Questions about Estradiol
  8. Estradiol Interactions with Food and Alcohol

Estradiol Benefits & Uses

Estradiol is used to treat the following -

  1. Post Menopausal Osteoporosis Primary
  2. Urethritis Primary
  3. Primary Ovarian Insufficiency
  4. Breast Cancer
  5. Prostate Cancer
  6. Pimples
  7. Contraceptives
  8. Vaginal atrophy Primary

Estradiol Dosage & How to Take

Find the right dosage based on disease and age

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Ingredients of Estradiol

Estradiol

Estradiol Side Effects

Based on research, the following side effects have been observed when Estradiol is used -

  1. Headache Mild
  2. Nausea or vomiting
  3. Mood swings
  4. Weight gain
  5. Sexual Dysfunction
  6. Breast Tenderness
  7. Breast Enlargement
  8. Abdominal Pain Mild
  9. Metrorrhagia
  10. Edema Common
  11. Fibroid
  12. Back Pain Mild
  13. Diarrhoea
  14. Skin irritation
  15. Breast pain
  16. Fluid retention
  17. Endometrial Hyperplasia

Estradiol Related Warnings

Is the use of Estradiol safe for pregnant women?

Estradiol can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.

Severe

Is the use of Estradiol safe during breastfeeding?

Estradiol may cause serious side effects in breastfeeding women, so do not take this drug without doctor's advice.

Severe

What is the effect of Estradiol on the Kidneys?

There may be some adverse effects on kidney after taking Estradiol. If you observe any such side effects, stop taking this drug. Consume this medicine again only if your doctor advises you to do so.

Moderate

What is the effect of Estradiol on the Liver?

Estradiol may have mild side effects on the liver. Most people will never see any effect on the liver.

Mild

What is the effect of Estradiol on the Heart?

You may experience side effects on your heart after taking Estradiol. If this happens, then discontinue its use. Consult your medical practitioner, and do as he/she suggests.

Moderate

Severe Interaction of Estradiol with Other Drugs

Estradiol should not be taken with following medicines due to severe side effects it may cause to patients -

Estradiol Contraindications

If you are suffering from any of the following diseases, you should not take Estradiol unless your doctor advises you to do so -

  1. Angioedema
  2. Liver Disease
  3. Depression
  4. High Blood Pressure
  5. Blood Clotting Disorders
  6. Thrombophlebitis

Frequently asked Questions about Estradiol

Is this Estradiol habit forming or addictive?

Estradiol is not addictive in nature.

No

Is it safe to drive or operate heavy machinery when consuming?

Estradiol will not make you feel sleepy or drowsy. So you drive or operate machinery safely.

Safe

Is it safe?

Yes, Estradiol is safe but you must consult your doctor before taking it.

Safe, but take only on Doctor's advise

Is it able to treat mental disorders?

No, the use of Estradiol in mental disorders is not effective.

No

Estradiol Interactions with Food and Alcohol

Interaction between Food and Estradiol

Due to the absence of research, it is difficult to say how Estradiol and food will interact.

Unknown

Interaction between Alcohol and Estradiol

Due to lack of research, nothing can be said about side effects of consuming alcohol while taking Estradiol.

Unknown

Estradiol FAQs

Question over 1 year ago

Can Estradiol cause hair loss?

Dr. Chinmaya Bal MBBS , General Physician

Yes, Estradiol can cause hair loss. It is a rare side effect of this drug. The exact cause behind is unknown. If you are experiencing hair loss after taking this drug, then do discuss it with your doctor.

Question about 2 years ago

What is Estradiol?

ram saini MD, MBBS , General Physician

Estradiol is a brand name of estradiol and it comes in the form of a tablet (solid unit dosage form). It belongs to the class of drug known as estrogen. Estradiol is a prescription drug which is used for hormone replacement therapy in menopausal women. It is also used for the prevention of postmenopausal osteoporosis.

Question almost 2 years ago

Does Estradiol cause breast enlargement?

Dr. Surender Kumar MBBS , General Physician

Yes, Estradiol may cause breast enlargement if the Estradiol is taken in high doses. It occurs due to hormonal effects of estradiol which causes the development of secondary female sex characteristics that includes breast enlargement. 

Question over 1 year ago

Can Estradiol cause depression?

Dr. Chinmaya Bal MBBS , General Physician

Yes, Estradiol might cause depression in a few cases only. It is a rare side effect of this drug and the exact cause behind this is unknown.

Question almost 2 years ago

Is Estradiol safe to use?

Dr. Surender Kumar MBBS , General Physician

Yes, Estradiol is safe to use, if taken in a prescribed amount for a specified time as advised by the doctor. However, few side effects have been observed at a regular dose such as a headache, abdominal cramps, nausea, and vomiting. Do not hesitate to inform your doctor if you are facing any of the above side effects.

This medicine data has been created by -
Vikas Chauhan
B.Pharma, Pharmacy
3 Years of Experience

References

  1. US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Estrace (estradiol)
  2. KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 306-309
  3. April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 526-528
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