What is Aluminium Urine test? 

Aluminium urine test is a screening test that is done to assess aluminium toxicity. 

Aluminium is a metal found abundantly in the environment. Everybody is exposed to small amounts of this metal via air, air, water, food and soil. It is also present in paints, utensils, deodorants and medications such as antacids, anti-diarrheal drugs and anti-ulcer medicines.

Normally, the absorbed aluminium is completely eliminated by the kidneys through urine. However, people who live in areas with high aluminium levels are regularly exposed to heavy amounts of this metal. Excess aluminium starts to accumulate in the body and can lead to toxicity. Other factors that increase the chances of developing aluminium toxicity are:

  • Working in an environment with high levels of aluminium
  • Being on intravenous nutrition for prolonged periods
  • Receiving haemodialysis
  • Having diminished kidney function

Patients suffering from renal failure are unable to clear aluminium from the body and are hence at constant risk of aluminium poisoning from:

  • Aluminium-laden dialysis water (if they are on dialysis)
  • Aluminium-laden albumin. Albumin is generally given to dialysis patients since it helps in the transfer of excess fluid from tissues to blood. This fluid is then removed by dialysis.
  • Aluminium-based phosphate binders (drugs that reduce the absorption of phosphate from the diet)

Aluminium toxicity can lead to the following complications:

  • Nervous system problems causing dementia and difficulty with movements
  • Bone diseases
  • Impaired iron absorption and anaemia
  • Lung disorders
  1. Why is an Aluminium Urine test performed?
  2. How do you prepare for an Aluminium Urine test?
  3. How is an Aluminium Urine test performed?
  4. Aluminium Urine test results and normal range

Aluminium urine test is performed for the following reasons:

  • To monitor exposure to aluminium 
  • To monitor metal implants

Your doctor may order this test if he/she notices certain symptoms suggestive of aluminium toxicity. These symptoms are:

However, a blood test gives more accurate results for aluminium levels in the body and hence a urine test is not recommended for routine screening.

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You do not need any special preparation for this test. Please let your doctor know about all the prescription and non-prescription medicines and supplements you may be taking, as some of these may contain aluminium and alter the test results. Your doctor may instruct you to discontinue some medicines before the test. 

If you have been administered with a gadolinium- or iodine-containing contrast medium, wait for at least 96 hours before collecting a urine sample as they can affect the test results. These mediums are usually given to patients before an X-ray or CT-scan.

The aluminium urine test is performed on a 24-hour urine sample. Your doctor or nurse will explain the procedure to you and tell you when to start the urine collection. You will be provided with a special container to collect the urine. A 24-hour urine sample is usually collected in the following manner:

  • Begin sample collection in the morning. Do not save the first urine specimen but note the time of the first urination of the day as the beginning of the 24-hour interval. 
  • For the next 24 hours, collect all the urine and keep it in an icebox or the refrigerator. 
  • The next day, collect the last urine specimen at the same time when you started the collection process.
  • Take the urine container to the laboratory for testing. 

Urine collection is very safe and does not involve any risks. However, the test results can be affected by certain factors such as:

  • Not storing the urine in a cold temperature
  • Skipping collection of a urine sample in the day
  • Collecting urine beyond the collection period
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Normal results:

The normal levels of aluminium in the 24-hour urine test are < 10 mcg/24 h (micrograms per 24 hours). If your results are below this value, it indicates that the amount of aluminium exposure is within safe limits.

Abnormal results:

If you eliminate more than 10 mcg of aluminium in 24 hours, it is an indication of excessive exposure to aluminium. 

People who are on chelation therapy for iron or aluminium toxicity excrete more aluminium in their urine. 

Those who have aluminium-based prosthetics also have a higher concentration of aluminium in their urine.

Depending on your results, your doctor may order further tests to confirm aluminium exposure levels. He/she may also advise you on how to limit aluminium exposure from your diet and other sources. 

Disclaimer: All results must be clinically correlated with the patient’s complaints to make a complete and accurate diagnosis. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor.

References

  1. Agency for Toxic Substances and Disease Registry [internet]. Center for Disease Control. Atlanta. GA. U.S. ToxGuideTM for Aluminum
  2. Meyer-Baron M, Schuper M, Knapp G, van Thriel C. Occupational aluminum exposure: evidence in support of its neurobehavioral impact. Neurotoxicology 2007;28:1068-1078. PMID: 17692380
  3. O'Shea S, Johnson DW. Review article: addressing risk factors in chronic kidney disease mineral and bone disorder: can we influence patient-level outcomes?. Nephrology 2009;14:416-427. PMID: 19563384
  4. Health Library. Beth Israel Lahey Health. Winchester Hospital. MA (U.S.A.); Aluminum Toxicity
  5. University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; 24-Hour Urine Collection
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