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What is cholestatic liver disease?

Cholestatic liver disease, also known as cholestasis, is a condition in which the flow of bile from the liver is either slowed down or blocked. It can be acute or chronic and can affect individuals of all age groups. It can be classified as extrahepatic cholestasis, which occurs outside the live and intrahepatic cholestasis, which occurs inside the liver.

What are its main signs and symptoms?

The symptoms of cholestasis are similar to hepatitis, which is one of its causes. The following are the symptoms of cholestasis:

  • Nausea
  • Dark-coloured urine
  • White or clay-coloured stool
  • Itching
  • Pain in the upper abdomen
  • Yellowing of skin and eyes
  • Difficulty in the digestion of some foods (Read more: Indigestion treatment)

What are its main causes?

Causes of cholestasis based upon the age group affected are:

  • Causes of cholestasis in infants and children
    • Genetic cause like zinc storage disorder
    • Mutation of a gene called cirrhn gene
    • Byler’s syndrome (a genetic autosomal recessive disorder)
  • Causes of cholestasis in adults
    • Prescription drugs
    • Herbal treatments
    • Over-the-counter drugs

Causes of cholestasis based upon the location:

How is it diagnosed and treated?

The doctor will prescribe the following tests if you are suspected to have cholestasis:

  • Liver function test: It will reveal increased levels of bile and serum alkaline phosphatase.
  • Imaging tests to assess the liver are as follows:
    • MRI of abdomen
    • Ultrasound imaging of the abdomen
    • CT scan of your abdomen
    • Endoscopic retrograde cholangiopancreatography

Treatment of cholestatic liver disease involves identification and treatment of the underlying cause of the condition. The treatments for cholestasis are as follows:

  • Symptomatic treatment: Pruritus (desire to itch or scratch) is the most common symptom, which may later cause sleep disturbances and thus, needs to be managed. Anion exchange resin like cholestyramine is commonly prescribed for the treatment of pruritus. Antibiotics are the second line of treatment for pruritus.
  • Specific treatment: Various antibiotic and corticosteroid therapy may be initiated depending upon the cause of the condition.

(Read more: Liver diseases types)

  1. Medicines for Cholestatic Liver Diseases

Medicines for Cholestatic Liver Diseases

Medicines listed below are available for Cholestatic Liver Diseases. Please note that you should not take any medicines without doctor consultation. Taking any medicine without doctor's consultation can cause serious problems.

Medicine NamePack SizePrice (Rs.)
HeparidHeparid 50 Mg Syrup81.6
HepasilHepasil 140 Mg Capsule111.42
Higado LHigado L Capsule110.0
LimarinLimarin 140 Capsule89.0
MarilivMariliv Drop84.7
SilbostinSilbostin 120 Mg Capsule112.5
SilybonSilybon 140 Tablet128.0
SilynovaSilynova 200 Mg Capsule230.0
SylolivSyloliv 140 Mg Tablet82.62
HepoxHepox 140 Mg Tablet57.2
Higado LsHigado Ls 150 Mg/500 Mg Capsule140.0
LivcoLivco Syrup90.0
LiverubinLiverubin 140 Tablet132.0
LivtecLivtec 140 Mg Tablet84.97
RejulivRejuliv 140 Mg Tablet95.0
UdimarinUdimarin 140 Mg/300 Mg Tablet0.0
AsilAsil Syrup87.71
ElivEliv Capsule82.51
Higado PlusHigado Plus Capsule90.47
Livobit SlLivobit Sl Syrup76.87
Livolin SLivolin S Capsule56.18
Lyrin BLyrin B Syrup124.88
NilivNiliv Syrup75.36
SlivSliv Suspension153.98
Ud Max SUd Max S Tablet275.0
ActimarinActimarin 70 Mg/150 Mg Tablet0.0
Gemiuro PlusGemiuro Plus Tablet0.0
Udimarin ForteUdimarin Forte 140 Mg/300 Mg Tablet0.0
UdiplusUdiplus 140 Mg/300 Mg Tablet0.0
Ulyses PlusUlyses Plus 140 Mg/300 Mg Tablet0.0
UdibonUdibon 140 Mg/300 Mg Tablet359.0
Urdohep SlUrdohep Sl 140 Mg/300 Mg Tablet273.9
Ursetor PlusUrsetor Plus 300 Mg/140 Mg Tablet306.61
Ursodox PlusUrsodox Plus Tablet298.0
Ursokem PlusUrsokem Plus 140 Mg/300 Mg Tablet341.0
Ursolic PlusUrsolic Plus Tablet250.0
ToxifiteToxifite Tablet180.97
Liv AptLiv Apt 250 Mg/70 Mg/50 Mg Tablet410.0
HepasafeHepasafe Suspension 200 Ml174.0
LivopillLivopill Syrup99.5

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