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What is Cushing’s syndrome?

Cushing’s syndrome is a hormonal disorder, which occurs due to the imbalance of the hormone cortisol (higher than normal cortisol levels) in the body. Cortisol is termed as the “stress hormone” as its levels increase during periods of stress. It can be endogenous (caused by internal factors) or exogenous (caused by external factors). Variable estimates show that 40 to 70 individuals per million are affected by Cushing’s syndrome worldwide. Its incidence in India varies from 0.7 to 2.4 per million population annually as per several population studies.

What are its main signs and symptoms?

Clinical features may be variable and include the following:

In adults, Cushing’s syndrome usually occurs between the ages of 30 to 50 years but can also develop in children. The incidence of Cushing’s syndrome is much higher in women than men (3:1 female to male ratio). Some uncommonly seen features are:

Other diseases (differential diagnosis) that can have similar symptoms include:

What are its main causes?

The main cause that results in the development of this syndrome is the frequent use of high-dose cortisol, especially glucocorticoids. Cortisol is useful as it has the following functions:

  • Maintains blood pressure and blood glucose levels
  • Reduces inflammatory conditions
  • Converts food into usable energy within the body

However, an imbalance can result in abnormal levels of cortisol which can lead to complications in the long run. It can be endogenous or exogenous (use of oral corticosteroids for a long period).

Other causes include:

  • Pituitary gland tumours
  • Ectopic tumours that generate the hormone ACTH
  • Adrenal gland tumours

How is it diagnosed and treated?

Diagnosis may mainly include:

  • Medical history.
  • Physical exam.
  • Lab tests.

Glucocorticoids are used mainly for anti-inflammatory, autoimmune, and neoplastic (tumour) diseases. Therefore, proper medication history of the patient is usually required. Other diagnostic tests that may be performed are:

  • A 24-hour urinary free cortisol (UFC).
  • Late night-salivary cortisol.
  • Low-dose dexamethasone suppression test (LDDST).
  • Overnight dexamethasone suppression test (ONDST).
  • CT scan of the adrenal glands.

Tests to diagnose an underlying condition that may be the cause of Cushing syndrome include:

  • Corticotropin-releasing hormone test (CRH).
  • High-dose dexamethasone suppression test (HDDST).
  • Bilateral inferior petrosal sinus sampling (BIPSS).

Treatment plan for Cushing’s syndrome includes:

  • Medical therapy: Depending on the underlying cause of this syndrome medications are given as follows.
    • To inhibit steroid production.
    • Glucocorticoid receptor inhibitors.
    • Modulate ACTH release.
    • Adrenolytic drugs.
    • If you have been taking cortisol, a lower dose is prescribed to reduce the symptoms.
  • Surgery:
    • Tumour surgery or removal of adrenal glands may be indicated.
  • Pituitary radiotherapy.

Self-care tips:

  • Follow the medication regimen prescribed by the physician.
  • Avoid smoking and consumption of alcohol, as they can cause more harm and may lead to complications.
  • Follow a well-balanced diet or consult a dietician.
  • Do regular low-intensity exercises, as there may be a risk of fractures while performing high-impact exercises or sports.
  • Avoid stress so that hyperproduction of cortisol is reduced.

Cushing’s syndrome can be managed if the above measures are followed judiciously and the physician is consulted as necessary.

  1. Medicines for Cushing's Syndrome
  2. Doctors for Cushing's Syndrome
Dr. B.P Yadav

Dr. B.P Yadav

एंडोक्राइन ग्रंथियों और होर्मोनेस सम्बन्धी विज्ञान

Dr. Vineet Saboo

Dr. Vineet Saboo

एंडोक्राइन ग्रंथियों और होर्मोनेस सम्बन्धी विज्ञान

Dr. JITENDRA GUPTA

Dr. JITENDRA GUPTA

एंडोक्राइन ग्रंथियों और होर्मोनेस सम्बन्धी विज्ञान

Medicines for Cushing's Syndrome

Medicines listed below are available for Cushing's Syndrome. Please note that you should not take any medicines without doctor consultation. Taking any medicine without doctor's consultation can cause serious problems.

Medicine NamePack SizePrice (Rs.)
DefloxDeflox 0.3%/0.1% Eye Drops12.0
AtiketAtiket Soap65.0
Canzol (Monichem)Canzol (Monichem) 2% W/W Cream98.0
DandelDandel 2%W/V Lotion128.0
DanketDanket 2% Shampoo240.0
DenonDenon 1% Shampoo180.0
EcoketEcoket 2% Lotion66.0
FungiketFungiket 2% Cream60.0
IycoticIycotic 2% Cream85.0
K2 ZoleK2 Zole 1%W/V Solution140.0
KatwalkKatwalk Powder66.0
KenzKenz 2% Lotion170.0
Ketafung 2% LotionKetafung 2% Lotion179.0
KetarKetar Scalp Solution123.0
KeticonKeticon 2% Cream45.0
Keto (Med Manor)Keto 2% Cream90.0
KetopanKetopan Cream80.0
KetopzKetopz Antifungal Powder58.0
KetorilKetoril 200 Mg Tablet99.01
KetostarKetostar 0.50% Eye Drop40.0
Ketovate (Bal)Ketovate 200 Mg Tablet250.0
KetozKetoz Soap61.0
KetralKetral 1%W/V Scalp Solution210.0
KetzolKetzol 2% Shampoo79.0
KevonKevon 2% Lotion210.0
Kevon ZipKevon Zip Hair Conditioner215.0
KitralKitral 2% W/V Shampoo162.0
KonazKonaz 2% Cream72.0
Kz (Hegdehegde)Kz Cream165.0
LogidrufLogidruf Lotion250.0
Monokit (Ampra)Monokit (Ampra) Cream51.0
NizoralNizoral 1%W/V Shampoo110.0
NizralNizral 2% Solution251.0
NodanNodan 2% Shampoo93.0
NovaleNovale 2% Soap159.0
NuketNuket 2% Shampoo74.0
OconaOcona 2% Soap62.0
Ocona CtOcona Ct 2% Solution120.0
PhytoralPhytoral 2% Ointment88.0
ProtekProtek 100 Gm Soap120.0
SolukenSoluken Lotion111.0
Tarry ShineTarry Shine Lotion230.0
TopdanTopdan 2% Solution125.0
TriatopTriatop 2%W/V Shampoo229.0
V DrufV Druf 2%W/V Lotion163.0
Cotar KCotar K 1% Lotion145.0
Czar (Omega Remedies)Czar (Omega Remedies) 2% Cream40.0
Dand CareDand Care Shampoo98.0
DanduraDandura Shampoo110.0
DanfreeDanfree 1% Shampoo78.0
DenzyDenzy Lotion125.0
ExizolExizol 2% Shampoo296.0
ForforaForfora 2% Cream139.0
JoynecaJoyneca 2% W/W Soap125.0
K2K2 Solution97.0
KenozoleKenozole 2% Cream130.0
Ketoco ShampooKetoco Shampoo 2% W/V143.0
KetodayKetoday Shampoo125.0
KetoflyKetofly 200 Mg Tablet41.67
Keto GoldKeto Gold Soap152.0
KetolKetol 2% W/V Shampoo66.0
Keto PlusKeto Plus Soap69.0
KetotarKetotar 2% Lotion150.0
KetotopKetotop Cream75.0
KetozapKetozap Gel72.0
KetziKetzi 2% W/W Cream99.0
KliniqueKlinique 1% W/V Shampoo199.0
KurazolKurazol Shampoo180.0
MesoketzMesoketz Cream100.0
MyketMyket Cream129.0
NozalNozal 2% Cream43.0
Nuket (Lancer Pharma)Nuket Solution74.0
RandruffRandruff 2%W/V Shampoo72.0
Salisia KtSalisia Kt 2% Shampoo197.0
SeboketSeboket 2% Lotion62.0
Senee TvSenee Tv Lotion140.0
TektarTektar Shampoo144.0
BiodexoneBiodexone 4 Mg Injection6.0
DecamycinDecamycin 4 Mg Injection33.0
DecdanDecdan 0.5 Mg Tablet1.0
DexajectDexaject 4 Mg Injection9.0
DexaDexa Injection20.0
DexonaDexona 0.5 Mg Tablet3.0
Dex ZDex Z Powder67.0
MeridecaMerideca 4 Mg Injection33.0
OzurdexOzurdex 0.7 Mg Injection24303.0
ZydexaZydexa 4 Mg Injection26.0
AuradexAuradex 8 Mg Tablet60.0
DecakemDecakem Injection7.0
DecdakDecdak St 0.5 Mg Tablet2.0
DecicortDecicort 0.5 Mg Tablet3.0
DecmaxDecmax 4 Mg Tablet16.0
DecoliteDecolite 0.01% Drops15.0
DeksaDeksa 4 Mg Injection5.0
DemisoneDemisone 0.5 Mg Tablet2.0
DexacipDexacip 0.1% Drops8.0
DexageeDexagee 0.5 Mg Tablet12.0
DexalabDexalab 4 Mg Injection13.0
Dexamethasone 0.5 Mg TabletDexamethasone 0.5 Mg Tablet3.0
DexapenDexapen 4 Mg Injection6.0
DexarilDexaril 4 Mg Injection12.0
DexasoneDexasone 0.10% Eye/Ear Drops7.43
DicorsoneDicorsone 0.5 Mg Injection6.0
LabizoneLabizone 20 Ml Injection22.0
Lodex(Syntho)Lodex 0.05% Drops9.0
LupidexaLupidexa 0.5 Mg Tablet2.0
MethasoneMethasone Tablet4.0
RavicortRavicort 4 Mg Injection9.0
UdicortUdicort 4 Mg Injection35.0
WymesoneWymesone 0.5 Mg Tablet2.0
AgidexAgidex Injection18.0
DecadronDecadron Injection10.0
DeexaDeexa 4 Mg Injection7.0
DexajetDexajet Injection9.0
DexamarkDexamark 4 Mg Injection9.0
Dexamethasone 4 Mg InjectionDexamethasone 4 Mg Injection12.0
Dexamethasone Sodium PhosphateDexamethasone Sodium Phosphate Injection85.0
DexamoxDexamox Kid Forte Tablet44.0
DexanirDexanir Injection9.0
DexasoleDexasole Injection5.0
DexasporinDexasporin Injection6.0
Dex EDex E Powder17.0
DexometDexomet 0.25% W/W Cream128.0
DexonilDexonil 4 Mg Injection63.0
DexonDexon Injection25.0
DexzyDexzy Injection5.0
OsidexOsidex Injection5.0
StedexStedex 0.5%/0.1% Eye Drops12.48
ZoftadexZoftadex 4 Mg Injection190.0
Abortab TabletAbortab 200 Mg Tablet325.0
MefetracMefetrac 200 Mg Tablet370.0
MefnilMefnil 200 Mg Tablet340.0
MensovitMensovit Forte Tablet537.5
MifeconMifecon 200 Mg Tablet63.75
MifeproMifepro 200 Mg Tablet318.0
Mt Pill TabletMt Pill Tablet398.42
Pregnot TabletPregnot 200 Mg Tablet50.0
TermipilTermipil 200 Mg Tablet336.53
Unwanted TabletUnwanted 200 Mg Tablet405.61
AntipregAntipreg 200 Mg Tablet525.0
ContrapillContrapill 200 Mg Tablet322.11
EjectEject 200 Mg Tablet325.0
FibroeaseFibroease 10 Mg Tablet499.0
MifeprinMifeprin 200 Mg/200 Mcg Kit450.0
RelezedRelezed 200 Mg Tablet79.68
CedateCedate 200 Mg Tablet71.08
ElmifElmif 200 Mg Tablet400.0
EmpriEmpri 200 Mg Tablet365.0
Lpill MLpill M Tablet517.4
MedabonMedabon 200 Mg Tablet21.6
MefipilMefipil 200 Mg Tablet329.4
MfkareMfkare 200 Mg Tablet300.0
MifabortMifabort 200 Mg Tablet355.77
MifemedMifemed 200 Mg Tablet399.3
Mifepristone 200 Mg TabletMifepristone 200 Mg Tablet58.67
MiffkayMiffkay Tablet81.25
MifitonMifiton Tablet315.0
MifyronMifyron 200 Mg Tablet334.75
Pri VcPri Vc 200 Mg Tablet320.0
TerpregTerpreg 200 Mg Tablet355.0
UndoUndo 200 Mg Tablet322.12
FungicideFungicide 200 Mg Tablet306.0
KezolKezol 200 Mg Tablet108.06
LirotekLirotek Tablet109.0
TriketTriket Tablet150.0
ExketExket 200 Mg Tablet135.0
FreekFreek 150 Mg Tablet9.9
HyphoralHyphoral 200 Mg Tablet240.0
HyporalHyporal 200 Mg Tablet199.0
KanazoleKanazole Infusion70.0
KetoKeto 200 Mg Tablet58.75
KetocipKetocip 1% W/V Shampoo199.0
KetofordKetoford 200 Mg Tablet158.0
KetozoleKetozole 200 Mg Tablet155.0
KkzoleKkzole 12.5% Soap65.12
Kz (Aigis)Kz 200 Tablet163.62
DexacortDexacort Eye Drop17.73
Dexacort (Klar Sheen)Dexacort (Klar Sheen) 0.1% Eye Drop18.62
SolodexSolodex 0.1% Eye/Ear Drops7.23
Lupidexa CLupidexa C Eye Drop9.75
Ocugate DxOcugate Dx Eye Drop10.62
DexapinDexapin 1%/0.10% Eye Drop20.0
Gate DxGate Dx 0.1%/0.3% Drops37.35
4 Quin Dx4 Quin Dx Eye Drop17.84
Apdrops DmApdrops Dm 0.5% W/V/1% W/V Eye Drop108.0
Dexcin MDexcin M Eye Drop67.0
Mfc DMfc D Eye Drop88.0
Mflotas DxMflotas Dx 0.5%W/V/0.1%W/V Eye Drop90.0
Mo 4 DxMo 4 Dx Eye Drop80.0
Moxifax DxMoxifax Dx Eye Drop55.0
Moxitak DmMoxitak Dm Eye Drops20.12
MyticomMyticom Eye Drop75.74
Occumox DmOccumox Dm 0.5%/0.1% Eye Drop17.8
Mflotas DMflotas D Eye Drop18.08
Mflotas TMflotas T Injection18.08
MilflodexMilflodex Eye Drop115.0
Milflox DmMilflox Dm Eye Drop21.3
Mosi DMosi D Eye Drop11.25
MoxigramMoxigram 400 Mg Tablet115.86
Occumox DOccumox D Eye Drop17.8
Aflox DAflox D 0.3%/0.1% Drops15.4
Amoflox DAmoflox D 0.3%/0.1% Eye Drops11.15
Deflox DmDeflox Dm Eye Drops27.62
Festive DFestive D 0.3%/0.1% Drop26.0
Flan DxFlan Dx Eye Drops13.75
O Cebran DO Cebran D 0.3%/0.1% Drops18.0
Ofc DxOfc Dx 0.3%/0.1% Drops10.67
OfdexOfdex 0.3%W/V/0.1%W/V Eye/Ear Drops12.0
Ofelder DOfelder D 0.3%/0.1% Drops10.53
Ofen DxOfen Dx 0.3%/0.1% Drops25.76
Oflo DmOflo Dm 0.3%/0.1% Eye Drops10.95
Oflomac DxOflomac Dx 0.3%/0.1% Eye/Ear Drops7.51
Oflozen DOflozen D 0.3%/0.1% Drops11.04
Olin DOlin D 0.3%/0.1% Eye Drops35.9
Omeflox DxOmeflox Dx 0.3%/0.1% Drops10.82
O Syn DxO Syn Dx Drops10.05
Oxop DOxop D 0.3%/0.1% Eye Drops11.71
Zevid DZevid D 0.3%/0.1% Drops16.8
Zo DZo D 0.3%/0.1% Eye Drop8.69
Zuflo DZuflo D 0.3%/0.1% Eye/Ear Drops8.75
Zynoff DZynoff D 0.3%/0.1% Eye Drop9.06
Oflacin DxOflacin Dx Eye Drop11.68
OfrondOfrond Eye Drops8.75
Protoflox DProtoflox D Eye/Ear Drops9.12
Appatoba DAppatoba D 0.3%/0.1% Eye Drops12.1
Itocin DItocin D 0.3%/0.1% Eye Drops21.25
Ocutob DOcutob D 0.3%/0.1% Eye Drops11.45
TobadexTobadex 0.3%/0.1% Eye Drops16.0
Tobaren DTobaren D 0.3%/0.1% Drops15.29
Tobaren DmTobaren Dm 0.3%/0.1% Eye Drops58.0
Tobazon DmTobazon Dm 0.3%/0.1% Drops9.92
TobradexTobradex 0.30%/.1% Drops18.29
Tobram DTobram D Eye Drops17.25
Toby DToby D 0.3%/0.1% Eye Drops11.08
Tojawa DTojawa D 0.3%/0.1% Drops13.67
TromadexTromadex 0.3%/0.1% Drops10.0
Paritob DParitob D Eye Drop37.71
TeradoxTeradox Eye Drops20.31
Tobacin DTobacin D Eye Drop35.9
Tobracid DmTobracid Dm Eye Drop13.56
Tobramed DTobramed D Eye/Ear Drops10.82
Tobrine DmTobrine Dm Eye Drops19.75
Tsun DTsun D Eye Drops19.15
TybroTybro Eye Drops40.0
Dexapin CDexapin C Eye Drop13.97
Biocip DBiocip D 0.3%/0.1% Drop9.8
Ceprolen DCeprolen D 0.3%/0.1% Eye Drops11.18
Ciplex (Leeford)Ciplex 0.3%/0.1% Eye Drops10.62
Cipromac D (Torque)Cipromac D Drop10.61
Ciprozen DCiprozen D 0.3%/0.1% Drops19.37
Kemocip DKemocip D 0.3%/0.1% Eye/Ear Drops9.71
Larcip DLarcip D 0.3%/0.1% Eye Drops7.25
Lucipro DLucipro D 0.3%/0.1% Eye/Ear Drops12.07
Zoxan DZoxan D 0.3%/0.1% Eye Drop8.59
Ahlox DAhlox D 0.3%/0.1% Eye Drops9.2
Cebran DCebran D Eye Drop9.33
Ceflox DCeflox D Drop26.0
Chlorodex (Sun)Chlorodex Drop10.0
Cifomed DCifomed D Drop16.75
Cipcos DCipcos D Drops14.0
Ciplox DCiplox D Eye/Ear Drops14.0
KemocipKemocip Eye/Ear Drops7.28
Swiflox DSwiflox D Eye Drop7.5
Garasol DGarasol D 0.3%/0.1% Drops11.5
Gencin D MGencin D M Drops18.0
Gentacip DGentacip D 0.3%/0.1% Drop9.62
Gentajin DGentajin D 0.3%/0.1% Eye Drops7.04
Gentamide DmGentamide Dm 0.3%/0.1% Eye Drops8.2
Gentapen DGentapen D 0.3%/0.1% Eye Drops8.36
Genticare DGenticare D 0.01%/0.3% Eye Drops9.66
GermentadGermentad 0.3%/0.1% Drops7.8
GlycortGlycort 0.3%/0.1% Drops10.0
Gentaglow DGentaglow D 0.3%/0.1% Eye Drops20.0
PyricortPyricort Eye Drop9.39
Biodexone NBiodexone N 0.5%/0.1% Eye Drops9.37
Dekortyn NDekortyn N 0.5%/0.1% Drops8.25
Dexacort NDexacort N 0.5%/0.1% Eye Ointment9.11
DexcinDexcin Eye/Ear Drops11.55
Opthodex NOpthodex N 0.5%/0.1% Drops9.41
Biosone PBiosone P Eye/Ear Drops40.0
Ocupol DOcupol D Eye Drop13.44
Renicol PxRenicol Px Eye Drops21.0
Takchlor CTakchlor C 10 Mg/1 Mg/5000 Iu Ointment46.2
Deximon PDeximon P Eye Drops22.5
Imix 10Imix 10 Eye Drops30.0
Imix D 10Imix D 10 Eye Drops80.0
Imix D 5Imix D 5 Eye Drops47.5
Imix DImix D Eye Drops36.25
Ocupol DxOcupol Dx Drop75.61
ClinhairClinhair 2%/1% Shampoo125.62
DanclearDanclear 1%/2% Gel214.16
DandropDandrop 2%/1% Lotion228.57
SeborenSeboren 2%/1% Shampoo97.0
CutiglosCutiglos Shampoo149.31
Dandruff PlusDandruff Plus Soap18.93
HighgrowHighgrow Shampoo129.37
KetokemKetokem Shampoo150.0
Cosalic KCosalic K Solution275.0
Novale CtNovale Ct 4% W/V/2% W/V Lotion216.0
DancureDancure 1%/2% Shampoo70.0
Triben AdTriben Ad Lotion216.0
D ChlorexD Chlorex Eye Drops7.99
Decakem CDecakem C Eye Drops11.76
DecoDeco 0.5%W/V/0.01%W/V Eye/Ear Drops10.62
Dekortyn CDekortyn C 1%/0.1% Drops8.86
DexamonDexamon 1%/0.1% Drops9.8
DeximonDeximon 0.5%/0.1% Eye Drops47.55
Eptico DEptico D 5%/0.1% Drops9.66
KlorumdKlorumd 1%/0.1% Drops7.8
OpthodexOpthodex 1%/0.1% Eye Drops9.4
Opthodex SOpthodex S Drops9.75
PolydexPolydex 1%/0.1% Eye/Ear Drops43.75
RenidexRenidex 1%/0.1% Drops8.89
AvimonAvimon Eye Drops11.0
CareCare Drops51.05
Chlorgull DChlorgull D Eye/Ear Drops7.37
ChloridexChloridex Eye Drops20.87
Chlormet DmChlormet Dm Drops11.75
Chlorodex (Leeford)Chlorodex Eye Drop10.0
ClodilClodil Eye Drops35.87
Pc DexPc Dex Eye/Ear Drops37.98
PyrimonPyrimon Eye Drop11.4
VisomerVisomer Eye Drop23.93
KedexKedex 0.5%/0.1% Eye Drop50.0
KetamideKetamide Soap70.0
SarotSarot 0.5%/2% Lotion195.0
BiokezBiokez Ad Lotion170.0
Klinique ActiveKlinique Active Lotion185.0
KetonateKetonate 0.03%/22% Cream36.5
KetrodexKetrodex Eye Drop70.0
Low DexLow Dex Eye/Ear Drops9.75
NordexNordex Eye Drops44.88
SofradexSofradex Cream29.42
Sofradex FSofradex F Cream25.58
Tympalin CTympalin C Drops45.0
Insta KitInsta 60 K Tablet599.0
Klinique PlusKlinique Plus Shampoo199.5

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