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What is Vitamin B12 deficiency?

Vitamin B12 is also known as cyanocobalamin and plays a vital role in cellular metabolism, particularly DNA synthesis and energy production. Vitamin B12 is absorbed in the small intestine after combining with a factor called the intrinsic factor that is released from the stomach. The deficiency of vitamin B12 causes the body to produce abnormal red blood cells leading to megaloblastic anaemia. Apart from this, it hampers transmission of nerve impulses and affects many other tissues like the hair follicle, spinal cord, etc.

What are the main associated signs and symptoms?

The early symptoms are mentioned below:

The severe symptoms are as follows:

What are the main causes?

Some of the causes of the deficiency are mentioned below:

  • An autoimmune condition called pernicious anaemia that results in malabsorption of B12 in the intestine
  • A family history of pernicious anaemia
  • Lack of vitamin B12-rich foods in diet, such as fish, eggs, meat, and mushrooms
  • Insulin and acidity medications that prevent adequate production of intrinsic factor in the stomach
  • Surgical removal of the stomach or intestines
  • Severe diseases of intestines like inflammatory bowel diseases
  • Cancer
  • Pregnancy

How is it diagnosed and treated?

A general examination of the patient, which involves a physical assessment of symptoms along with a detailed history helps diagnose the condition.

Blood tests include

  • Haemoglobin levels – Less haemoglobin levels indicate anaemia
  • Vitamin B12 levels
  • Picture of red blood cells – Larger size of blood cells indicate a deficiency
  • Measurement of indicators of B12, i.e., serum homocysteine or methylmalonic acid
  • Schilling test to detect pernicious anaemia

The treatment modalities include

  • Supplementation of oral or injection vitamin B12
  • Dietary changes to include more foods that are rich in vitamin B12.
  1. Medicines for Vitamin B12 Deficiency
  2. Doctors for Vitamin B12 Deficiency
Dr. B.P Yadav

Dr. B.P Yadav

एंडोक्राइन ग्रंथियों और होर्मोनेस सम्बन्धी विज्ञान

Dr. Vineet Saboo

Dr. Vineet Saboo

एंडोक्राइन ग्रंथियों और होर्मोनेस सम्बन्धी विज्ञान



एंडोक्राइन ग्रंथियों और होर्मोनेस सम्बन्धी विज्ञान

Medicines for Vitamin B12 Deficiency

Medicines listed below are available for Vitamin B12 Deficiency. Please note that you should not take any medicines without doctor consultation. Taking any medicine without doctor's consultation can cause serious problems.

Medicine NamePack SizePrice (Rs.)
Macrabin 1000 Mcg InjectionMacrabin 1000 Mcg Injection181.37
Vib 12Vib 12 1000 Mcg Injection10.0
Meaxon Gold InjectionMeaxon Gold Injection97.0
VitcofolVitcofol Capsule71.4
UnifolUnifol 15 Mcg/500 Mcg Injection45.0
Beplex PlusBeplex Forte Plus Elixir50.53
PolybionPolybion Capsule17.0

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