Grafmet

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  • Contains / Salt: Methylprednisolone (500 mg)
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Grafmet Information

Grafmet is a commercial drug that is prescribed in the form of Injection. Primarily, it is used for the treatment of Ulcerative Colitis, Rheumatoid Arthritis. Secondary and off-label uses of Grafmet have also been mentioned below.

Medical history of the patient along with age and gender determines the dosage of Grafmet. Dosage also depends on the route of administration and your chief complaint for which the drug is prescribed. For detailed information on this, read through the dosage section.

The most common side effects of Grafmet are Agitation, Anxiety, Blurred vision. Besides the aforementioned side effects, there are other adverse effects of Grafmet as well, which are listed below. Usually, these side effects of Grafmet go away soon, and do not persist beyond the duration of the treatment. If, however, they worsen or do not go away, please speak with your physician.

Furthermore, you should know that effect of Grafmet is Moderate for pregnant women and Moderate for women who are breastfeeding. In addition, Grafmet's effects on the liver, heart and kidney are discussed below in the Grafmet related warnings section.

Grafmet is not recommended if you suffer from certain medical conditions as it can have adverse effects. Tuberculosis (TB), Infections, Peptic Ulcer are examples of such conditions. The section on Grafmet contraindications lists all such conditions.

Besides this, Grafmet may also have severe interaction with some medicines. Refer to the list below for further details.

Along with the above-mentioned precautions, remember that taking Grafmet is considered safe while driving, and is addictive.



Grafmet Benefits & Uses

Grafmet is used to treat the following -

Other Benefits

Grafmet Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Anaphylactic Shock
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 120 mg
  • Dosage Route: Parenteral
  • Frequency: 1 Weekly
  • Course Duration: 4 weeks
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Anaphylactic Shock
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 120 mg
  • Dosage Route: Parenteral
  • Frequency: 1 Weekly
  • Course Duration: 4 weeks
  • Special Instructions: As prescribed by the doctor
13 - 18 years (Adolescent)
  • Disease: Anaphylactic Shock
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 120 mg
  • Dosage Route: Parenteral
  • Frequency: 1 Weekly
  • Course Duration: 4 weeks
  • Special Instructions: As prescribed by the doctor
2 - 12 years (Child)
  • Disease: Anaphylactic Shock
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 0.4 mg/kg
  • Dosage Route: Parenteral
  • Frequency: 1 Weekly
  • Course Duration: 4 weeks
  • Special Instructions: As prescribed by the doctor

Grafmet Related Warnings

  • Is the use of Grafmet safe for pregnant women?


    Grafmet can have harmful effects in pregnant women. If you experience any discomfort after using Grafmet, then discontinue the use and take your doctor's advice.

    Moderate
  • Is the use of Grafmet safe during breastfeeding?


    Breastfeeding women may feel side effects of Grafmet. If you see any side effects, stop taking Grafmet immediately and talk to your doctor. Take Grafmet again, only after your doctor's advice.

    Moderate
  • What is the effect of Grafmet on the Kidneys?


    There may be some adverse effects on kidney after taking Grafmet. If you observe any such side effects, stop taking this drug. Consume this medicine again only if your doctor advises you to do so.

    Moderate
  • What is the effect of Grafmet on the Liver?


    There may be an adverse effect on the liver after taking Grafmet. If you observe any side effects on your body then stop taking this drug. Take this medicine again only if your doctor advises you to do so.

    Moderate
  • What is the effect of Grafmet on the Heart?


    Grafmet may cause harmful effects on the heart. if you feel it's having any such effect, then stop taking this drug, and restart only on your doctor's advice.

    Moderate


Severe Interaction of Grafmet with Other Drugs

Grafmet should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate



Grafmet Contraindications

If you are suffering from any of the following diseases, you should not take Grafmet unless your doctor advises you to do so -



Frequently asked Questions about Grafmet

  • Is this Grafmet habit forming or addictive?


    No, there is no any evidence that Grafmet is addictive.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    Grafmet will not make you feel sleepy or drowsy. So you drive or operate machinery safely.

    Safe
  • Is it safe?


    Yes, Grafmet is safe but you must consult your doctor before taking it.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Grafmet is not used to treat mental disorders.

    No

Grafmet Interactions with Food and Alcohol

  • Interaction between Food and Grafmet


    Due to the absence of research, it is difficult to say how Grafmet and food will interact.

    Unknown
  • Interaction between Alcohol and Grafmet


    Information about the interaction of Grafmet and alcohol is not currently available because this topic has not been researched yet.

    Unknown


Frequently asked Questions about Grafmet

Question about 5 years ago

Can Grafmet cause depression or mood change?

Dr Anjum Mujawar MBBS, MBBS , Emergency Medicine

Yes, Grafmet can cause depression or mood change. Research suggests that Grafmet lower the serotonin level in the body, and it is known that lowered serotonin levels cause depression and another psychiatric disease.

Question over 4 years ago

Can I take Grafmet with phenylephrine?

Dr. Rajeev Kumar Ranjan MBBS , Pulmonology

Yes, Grafmet can be taken with phenylephrine. No harmful drug interactions have been reported between them. However, if you feel any discomfort or unpleasant effects after taking this drug to inform your doctor immediately.

Question almost 5 years ago

Can I discontinue Grafmet on my own?

Dr. , General Physician

No, you should not discontinue Grafmet on your own as that might result in disease relapse and some side effects. You must completely comply with the dosing schedule, never miss a dose, never take an extra dose and never stop taking Grafmet without talking to the doctor. It is, therefore, important that you follow the recommendations of your doctor completely.

Question over 4 years ago

Can Grafmet cause allergy?

Dr. Ramraj Meena MBBS , General Physician

Yes, Grafmet may cause allergy in rare cases. The symptoms could be rash, itching, extreme dizziness, swelling of the tongue, throat, and face, difficulty in breathing, etc. If you experience any of these symptoms, discontinue using Grafmet and talk to your doctor immediately. 

Question almost 5 years ago

Is it safe to take Grafmet?

Dr Anjum Mujawar MBBS, MBBS , Emergency Medicine

Yes, it is safe to take Grafmet as long as it is prescribed by a doctor and one follows the prescription completely. However, in some people, it may cause some side effects like muscle weakness, headache, weight gain, skin rashes, and vision problem. If you suffer from any of these side effects, please talk to your doctor immediately.    



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This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Medrol® methylprednisolone

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 288-289

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