Dr. Sameer Awadhiya MBBS , Pediatrics

Yes, Mikacin Injection can be taken with lidocaine. The clinical report suggests that no harmful drug-drug interactions have been observed between them so far. However, it doesn't mean that no interaction could exist between them. These two medicines are high alert drug so you must consult your doctor before taking Mikacin Injection together.

Dr. Anjum Mujawar MBBS , Diabetology

Yes, Mikacin Injection is nephrotoxic. Nephrotoxicity depends on dose and duration of therapy. Thus, nephrotoxicity is likely to occur if Mikacin Injection taken a high dose for a long time or may occur if the drug is given to a patient that already suffer from kidney problem. Nephrotoxicity associated with this drug may reduce or minimize by taking some precaution before consuming this drug like monitor kidney functions regularly and do not take it in high doses. Avoid taking Mikacin Injection with another nephrotoxic drug. If you notice any urine discoloration after taking this drug then inform your doctor immediately.

Dr. Braj Bhushan Ojha BAMS , Gastroenterology, Dermatology, Psychiatry, Ayurveda, Sexology, Diabetology

No, Mikacin Injection cannot be taken with penicillin. Because penicillin inactivates the Mikacin Injection by combining the beta-lactam ring of penicillin with an amino group of this drug to form amide which is biologically inactive. For this reason Mikacin Injection should not be taken with penicillin. The chances of inactivation of this drug are higher in case of renal failure because in this case concentration of penicillin is higher in the kidney for a longer time as compared to the normal renal function. 

Dr. Abhijit MBBS , General Physician

Do not self-administer Mikacin Injection. It comes in the form of injection and given preferably 2 - 3 times in a day (Intravenously). Discontinuing the medicine in between may promote resistant bacteria which result in a relapse of the infection. You are recommended to complete the 7 - 10 days course even after getting symptomatic relief. In case you feel any discomfort such as hearing loss and nephrotoxicity while taking Mikacin Injection please inform your doctor immediately. 

Dr. Anjum Mujawar MBBS , Diabetology

Mikacin Injection is a broad-spectrum antibiotic which is active against both Gram-positive and Gram-negative bacteria. It works by preventing the synthesis of proteins that bacteria need to survive, in the absence of protein synthesis bacteria become vulnerable and dies. It is effective against different types of bacteria such as Escherichia coli, Proteus species, S. aureus, Acinetobacter and Serratia species.