What is Benzodiazepines Urine test?

Benzodiazepines are a class of drugs that are widely used to manage mental conditions such as anxiety. They have a tranquillising and sedative effect on the body and also help relax muscles.

Additionally, benzodiazepines are used to prevent seizures, cure muscle spasms and as sleep aids. However, these are also one of the most commonly abused drugs. Constant or regular use of this drug can lead to its addiction.

A benzodiazepines urine test measures the levels of benzodiazepine molecules or metabolites in your urine. This test is also known as a toxic urine screen and urine toxicology screening. Though a blood sample may be used to check for benzodiazepines, a urine test is less invasive and provides a bigger sample for testing. Also, higher concentrations of the concerned molecule are present in urine. 

Unlike Benzodiazepines blood test, this test is not useful as a quantitative test, it only works well as a qualitative test. It means that the test can detect if the drug is present in your body but it won’t be able to tell exactly how much.

  1. Why is a Benzodiazepines test performed?
  2. How do you prepare for a Benzodiazepines test?
  3. How is a Benzodiazepines test performed?
  4. Benzodiazepines Urine test results

A benzodiazepines test may be done as part of a toxicology screen or drug screen for one of the following reasons:

  • To know if the person has drug toxicity.
  • If a person is prescribed benzodiazepines. This test may be done to check if he/she is taking the medicines in the recommended amount.
  • For legal purposes or as a part of employment process, to tell if a person has been involved in drug abuse
  • In case a person shows any of the following signs of drug overdose:
    • Slurred speech
    • Confusion
    • Loss of control over muscles
    • Decline in the ability to talk or think properly
    • Seizures
    • Loss of consciousness
    • Drop in blood pressure
    • Shallow and slow breathing
    • Cardiac arrest

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No preparation is required before this test. 

Inform your doctor or lab technician if you are using any medicines or supplements as certain medicines may affect the test results. 

A benzodiazepines test can be performed at any time of the day. You will be provided with a special container to collect the urine sample. To avoid contamination, make sure to wash and clean your genital area before collecting the sample. 

A technician or nurse may provide you with more details about the collection and storage procedure. 

If the test is being done as part of a legal proceeding, you may need to deposit the sample in the presence of a laboratory person to avoid any malpractice.

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Normal results:

A normal result is written as negative. It indicates that no drug metabolite was found in your urine. Drug metabolite is the substance which is formed after the body has processed the main drug molecule. However, a normal result may not always mean that you have not taken the drug at all. It could mean the amount of metabolite is below the detection levels.

Abnormal results:

Abnormal results are usually reported as positive. It means that there is enough drug metabolite in your body to be detected using this test. However, the presence of the drug metabolite in urine does not indicate the quantity of the drug used. It is merely an indicator of usage. The test results are affected by the interval between drug intake and the time of the test. 

Additionally, different forms of benzodiazepine molecules are processed in the body in a different manner. They all take a different amount of time to reach the urine.

Sometimes, a false-positive result in a toxicology screen occurs due to interference from medicines given to treat cough, cold, pain and infections, etc. Speak with your doctor if you have any questions about the results. He/she will be able to explain what the result indicates as per your age, sex and health condition.

Disclaimer: All results must be clinically correlated with the patient’s complaints to make a complete and accurate diagnosis. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor.


  1. University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; Benzodiazepines (Urine)
  2. Harvard Health Publishing. Harvard Medical School [internet]: Harvard University; Benzodiazepines (and the alternatives)
  3. Provan D. Oxford Handbook of Clinical and Laboratory Investigation. Poisoning and Overdose. 4th ed. United Kingdom: Oxford University Press. 2018. Pp:700. Chapter 11.
  4. Wilson DD. McGraw-Hill’s Manual of Laboratory & Diagnostic Tests. McGraw-Hill. 2008. Pp:560.
  5. National Health Service [internet]. UK; How should I collect and store a pee (urine) sample?
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