What is Albumin/Creatinine Ratio? 

The albumin/creatinine ratio is a test that detects small amounts of albumin in the urine. The test is used to diagnose and monitor the progression of kidney diseases.

Albumin is a protein that your body needs for tissue growth and healing. Normally your urine does not have any albumin, though it is found in your blood. If your kidneys are not functioning properly, some amount of albumin may leak into your urine. The amount of urine albumin may vary throughout the day.

On the other hand, creatinine is a waste product of normal muscle breakdown. It is released into the urine at a steady rate. The amount of creatinine present in the urine thus provides a good measure of the normal urine concentration, which can serve as a standard to compare the severity of albumin secretion in the urine. So, unlike an albumin test, the albumin/creatinine ratio provides an accurate measure of the albumin in the urine. 

Small amounts of albumin in the urine may indicate early kidney disease. Early diagnosis of kidney disease is important to help treat it successfully and prevent future complications.

Kidney damage may occur due to diseases that affect only the kidneys or due to conditions that affect many parts of the body, like lupus (a disease where the immune system attacks the body’s own tissues) and diabetes. People who have diabetes, heart disease, high blood pressure are at a higher risk of kidney disease.

  1. Why is an Albumin/Creatinine Ratio test performed?
  2. How do you prepare for Albumin/Creatinine Ratio test?
  3. How is an Albumin/Creatinine Ratio test performed?
  4. Albumin/Creatinine Ratio results and normal range

This test is frequently performed to detect if you have kidney damage due to diabetes. Individuals who are more than 12 years of age and suffering from diabetes should take this test every year.

Those with type 1 diabetes should begin taking this test after five years of having the disease and once every year after that.

Your doctor may also order this test periodically if you have high blood pressure.

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You don’t need any particular preparation for this test. However, avoid vigorous exercise before the test as this may affect your results.

Also, inform your healthcare provider if you take any vitamins, supplements and medicines (including over-the-counter and illicit medicines).

Your healthcare provider will either ask for a 24-hour urine sample or a random urine sample. A single urine sample is easier to collect than a 24-hour sample and is usually sufficient for diagnosis.

Regardless of the procedure, you will be provided with a special container for sample collection. Here is the right way to collect the sample: 

Random sample

  • Wash your hands.
  • Clean your genital area using sterile wipes. Women should open their labia and clean the area from front to back; men should clean the head of the penis.
  • Start urinating in the bowl and collect the mid-stream urine in the container.
  • Shut the container and clean your hands.

A mid-stream urine sample means you don’t collect the first and last part of the urine. This method minimises contamination of the urine sample with bacteria from your hands or from the skin around the urethra - the tube that carries urine out of your body.

24-hour sample

For the 24-hour urine sample, you will be instructed to collect all your urine in a 24-hour period. It is best to start collecting the sample in the morning. The first urine of the day is however not collected. Instead, it is noted as the beginning of the 24 hour period. Collect all the urine passed during the next 24 hours in the container provided and store the sample in a refrigerator. Return the sample container to the laboratory technician as instructed.

The test result may vary depending on your gender, age, health history and other factors.

Normal results: 

The albumin/creatinine ratio is expressed in milligrams of albumin per gram of creatinine (mg/g creatinine). The normal albumin/creatinine ratio is < 30 mg/g creatinine and is a sign of normal kidney function.

Abnormal results: 

Moderately increased albumin in the urine, in the range of 30-299 mg/g creatinine, is referred to as microalbuminuria and indicates early kidney disease. Higher levels of albumin in the urine is seen in severe kidney disease.

However, microalbuminuria can also occur due to:

  • Diabetes
  • Cardiovascular disease
  • High blood pressure
  • Urinary bleeding
  • Haemoglobinuria (presence of haemoglobin, a protein found in red blood cells, in the urine)
  • Myoglobinuria (presence of myoglobin, a protein found in muscles, in the urine)

Additionally, urinary infection, blood in the urine and acid-base imbalance in the blood may cause microalbuminuria.

(Read more: Microalbumin test)

Disclaimer: All results must be clinically correlated with the patient’s complaints to make a complete and accurate diagnosis. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor.

References

  1. University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; Microalbumin (Urine)
  2. National Kidney Disease Education Program [Internet]: National Institute of Diabetes and Digestive and Kidney Diseases. US Department of Health and Human Services; Urine: Albumin-to-Creatinine Ratio (UACR)
  3. Lab Tests Online. Washington D.C.: American Association for Clinical Chemistry; 24-Hour Urine Sample
  4. National Institute of Diabetes and Digestive and Kidney Diseases [internet]: US Department of Health and Human Services; Assess Urine Albumin
  5. Nemours Children’s Health System [Internet]. Jacksonville (FL): The Nemours Foundation; c2017. Urine Test: Microalbumin-to-Creatinine Ratio
  6. University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; 24-Hour Urine Collection
  7. UW Health [Internet]. Madison (WI): University of Wisconsin Hospitals and Clinics Authority; Health Information: Albumin Urine Test
  8. American Diabetes Association [internet]; Common Terms
  9. Lab Tests Online. Washington D.C.: American Association for Clinical Chemistry; Urine Albumin and Albumin to Creatinine Ratio
  10. Nah EH, Cho S, Kim S, Cho HI. Comparison of Urine Albumin-to-Creatinine Ratio (ACR) Between ACR Strip Test and Quantitative Test in Prediabetes and Diabetes. Ann Lab Med 2017 Jan; 37(1): 28–33. PMID: 27834062
  11. National Kidney Foundation [Internet]. New York (NY), U.S. Know Your Kidney Numbers: Two Simple Tests
  12. National Institute of Diabetes and Digestive and Kidney Diseases [internet]: US Department of Health and Human Services; Nephrotic Syndrome in Adults
  13. Pagana KD, Pagana TJ, Pagana TN. Mosby’s Diagnostic & Laboratory Test Reference. Microalbumin (MA). 14th ed. 2019. Pp:626-27
  14. National Health Service [internet]. UK; How should I collect and store a pee (urine) sample?
  15. Benioff Children's Hospital [internet]: University of California, San Francisco; Hemoglobinuria
  16. Trivedi DJ, Kulkarni SP, Mudaraddi R. Primary Myoglobinuria: Differentiate Myoglobinuria from Hemoglobinuria. Indian J Clin Biochem. 2017 Jul;32(3):367-369. PMID: 28811700

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