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What are blood clotting disorders?

Blood clotting disorders are conditions in which either bleeding continues for longer durations or the blood gets clogged up within the blood vessels. If bleeding continues for a longer duration within the internal organs or blood vessels, it can become a medical emergency.

What are its main signs and symptoms?

There are two main types of blood clotting disorders, bleeding disorders and clotting disorders, each type with their respective symptoms.

Signs and symptoms of bleeding disorders:

Signs and symptoms of clotting disorder:

Clotting disorders are also known as hypercoagulable states. In these conditions, a blood clot is formed in the veins, and this clot, due to pressure, is dislodged into the circulation. Once the blood clot goes into the circulation, it can get stuck in smaller blood vessels or capillaries causing their blockage; and symptoms develop depending upon which organ’s blood vessel is blocked.

 Here are common symptoms of hypercoagulable states:

What are its main causes?

Mechanism of blood clotting involves platelets, clotting factors, and proteins; thus, the causes of blood clotting disorders include abnormalities in any of these blood components. The most common causes of bleeding disorders include:

  • Heredity – Common diseases are haemophilia, which is due to poor formation of clotting factors caused by a genetic mutation.
  • Vitamin K deficiency – Diet deficient in vitamin K can cause bleeding issues.
  • Liver disease or liver failure –Liver damage due to cirrhosis, hepatitis or fatty degeneration, can reduce the production of clotting factors and result in bleeding disorders.
  • Drug-induced – Certain drugs like aspirin and warfarin are known to alter the mechanism of blood clotting and their prolonged use can result in clotting disorders.

Common causes of hypercoagulable states include:

How are they diagnosed and treated?

Usually, the medical history and a careful medical examination help in establishing the diagnosis of blood clotting disorders, yet certain blood tests are useful in determining the cause of these diseases. These include:

  • Complete blood count – Low platelet levels can be indicative of clotting issues.
  • Bleeding time & clotting time –  Finding out bleeding and clotting time can help in identifying the type of issue (this test is obsolete now, as it is replaced by prothrombin time and activated partial thromboplastin time).
  • Prothrombin time (PT) – Usually, it is calculated with internal normalized ratio (INR) levels which help in determining the blood clotting time.
  • Activated partial thromboplastin time (aPTT) – This also helps in identifying clotting time.
  • Certain other specific tests include Protein C activity, Protein S activity, Anti-thrombin activity etc.

Treatment of blood clotting disorder is based on the cause of the disease. Treatment can be cause-based, symptomatic

Certain medicines used for treatment include:

  • Anti-platelet factors – Aspirin and clopidogrel, which reduce platelet aggregation and clotting.
  • Anticoagulants – Warfarin, heparin, low molecular weight heparin (LMWH), and fondaparinux are the drugs that prevent blood coagulation and can help in treating hypercoagulable states.
  • Vitamin K supplements – In case of vitamin K deficiency, supplementing with vitamin K is helpful.
  • Blood transfusion or platelet transfusion – In case of platelet deficiency, transfusing blood platelets help in restoring bleeding issues.
  • Factor replacement therapy – Helpful in treating haemophilia.
  1. Medicines for Blood Clotting Disorders

Medicines for Blood Clotting Disorders

Medicines listed below are available for Blood Clotting Disorders. Please note that you should not take any medicines without doctor consultation. Taking any medicine without doctor's consultation can cause serious problems.

Medicine NamePack SizePrice (Rs.)
ClopitorvaClopitorva 10 Mg/75 Mg Capsule143
Clopitab ACLOPITAB A 150MG CAPSULE 10S60
Rosave TrioRosave Trio 10 Mg Tablet112
Atorfit CvATORFIT CV 10MG TABLET 10S167
ClavixCLAVIX GOLD 10MG CAPSULE 15S0
ClopitabClopitab 150 Mg Tablet78
Rosutor GoldROSUTOR GOLD 20/150MG CAPSULE207
Ecosprin Av CapsuleEcosprin-AV 150 Capsule36
Rosave CRosave C 10 Mg/75 Mg Capsule116
Rosufit CvROSUFIT CV 10MG TABLET 10S187
Deplatt CvDEPLATT CV 10MG CAPSULE 10S51
Ecosprin GoldECOSPRIN GOLD 10MG CAPSULE 10S84
EcosprinEcosprin 150 Mg Tablet6
Deplatt ADEPLATT A 150MG TABLET 15S49
DeplattDeplatt 150 Tablet121
AcitromACITROM 4MG TABLET 10S53
PolycapPOLYCAP CAPSULE 10S200
PolytorvaPolytorva 10 Mg/150 Mg/2.5 Mg Kit84
Prax APrax A 75 Capsule188
Rosvin GoldROSVIN GOLD 10MG CAPSULE88
Rozat CVROZAT-CV 10/75MG CAPSULE 10S116
Rozucor GoldROZUCOR GOLD 10MG CAPSULE 10S104
Rxtor GoldRXTOR GOLD 10MG CAPSULE 10S104

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References

  1. Stuart Ralston, Ian Penman, Mark Strachan, Richard Hobson. Davidson's Principles and Practice of Medicine E-Book. 23rd Edition: Elsevier; 23rd April 2018. Page Count: 1440
  2. J. Larry Jameson et al. Rediff Books Flipkart Infibeam Find in a library All sellers » Shop for Books on Google Play Browse the world's largest eBookstore and start reading today on the web, tablet, phone, or ereader. Go to Google Play Now » Books on Google Play Harrison's P. 20, illustrated; McGraw-Hill Education, 2018. 4400 pages
  3. Northwestern University. Blood Clotting Disorders. [Internet]
  4. National Hemophilia Foundation. Bleeding Disorders. [internet]
  5. MedlinePlus Medical Encyclopedia: US National Library of Medicine; Blood Clots
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