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Diphenhydramine Information

Diphenhydramine Benefits & Uses

Diphenhydramine is used to treat the following -

Diphenhydramine Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

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Ingredients of Diphenhydramine


Diphenhydramine Side Effects

Based on research, the following side effects have been observed when Diphenhydramine is used -

  1. Nausea or vomiting
  2. Nervousness
  3. Palpitations (fluttering in chest)
  4. Skin irritation
  5. Blurred vision
  6. Confusion
  7. Convulsion
  8. Dizziness Mild
  9. Drowsiness
  10. Dry Mouth Mild
  11. Difficulty urinating
  12. Fatigue Mild
  13. Headache Mild
  14. Hypersensitivity
  15. Muscle twitching (painless)
  16. Tachycardia
  17. Unsteadiness
  18. Sleepiness
  19. Seizures (uncontrollable jerking of limbs)
  20. Constipation Moderate
  21. Hallucinations

Diphenhydramine Related Warnings

Is the use of Diphenhydramine safe for pregnant women?

Diphenhydramine can have harmful effects in pregnant women. If you experience any discomfort after using Diphenhydramine, then discontinue the use and take your doctor's advice.


Is the use of Diphenhydramine safe during breastfeeding?

Women who are breastfeeding may experience severe harmful effects after taking Diphenhydramine. It should only be taken after medical advice.


What is the effect of Diphenhydramine on the Kidneys?

Diphenhydramine may have mild side effects on the kidneys.


What is the effect of Diphenhydramine on the Liver?

The liver can be affected by Diphenhydramine. If you experience any unwanted effects of this drug, stop taking it and consult your doctor. You should restart Diphenhydramine only after medical advice.


What is the effect of Diphenhydramine on the Heart?

Diphenhydramine is rarely harmful for the heart.


Severe Interaction of Diphenhydramine with Other Drugs

Diphenhydramine should not be taken with following medicines due to severe side effects it may cause to patients -

Diphenhydramine Contraindications

If you are suffering from any of the following diseases, you should not take Diphenhydramine unless your doctor advises you to do so -

  1. Asthma
  2. Liver Disease
  3. Glaucoma
  4. Peptic Ulcer
  5. Hyperthyroidism
  6. Depression

Frequently asked Questions about Diphenhydramine

Is this Diphenhydramine habit forming or addictive?

Forming a habit of Diphenhydramine has not been reported.


Is it safe to drive or operate heavy machinery when consuming?

After taking Diphenhydramine, you should not drive or work on any heavy machine, as Diphenhydramine can make you drowsy.


Is it safe?

Yes, but consume Diphenhydramine only on doctor's advice.

Safe, but take only on Doctor's advise

Is it able to treat mental disorders?

Diphenhydramine is unable to treat or cure mental disorders.


Diphenhydramine Interactions with Food and Alcohol

Interaction between Food and Diphenhydramine

There isn't any research available on the side effects of taking Diphenhydramine with food.


Interaction between Alcohol and Diphenhydramine

Consumption of alcohol and Diphenhydramine together may have severe effects on your health.

This medicine data has been created by -
Dr. Md Saadullah
M.Pharma, Pharmacy
3 Years of Experience
View Doctor Profile
Dr. Vikas Chauhan
B.Pharma, Pharmacy
2 Years of Experience
View Doctor Profile

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  1. April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 441-443
  2. KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 663
  3. US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Diphenhydramine (diphenhydramine hydrochloride)